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dc.contributor.authorKrenz, Björn
dc.date.accessioned2018-12-10T08:19:49Z
dc.date.available2018-12-10T08:19:49Z
dc.date.created2018
dc.date.issued2018-12-10
dc.identifier.urihttps://hdl.handle.net/10630/17011
dc.description.abstractPlant viruses have the ability to redirect host machineries and processes to establish a productive infection. Virus-host interactions lead to the reprogramming of the plant cell cycle and transcriptional controls, inhibition of cell death pathways, interference with cell signaling and protein turnover, and suppression defense pathways. Stress granules (SGs) are structures within cells that regulate gene expression during stress response, e.g. viral infection. In mammalian cells assembly of SGs is dependent on the Ras-GAP SH3-domain–binding protein (G3BP). The C-terminal domain of the viral nonstructural protein 3 (nsP3) of Semliki Forest virus (SFV) forms a complex with mammalian G3BP and sequesters it into viral RNA replication complexes in a manner that inhibits the formation of SGs. The binding domain of nsP3 to HsG3BP was mapped to two tandem ‘FGDF’ repeat motifs close to the C-terminus of the viral proteins. It was speculated that plant viruses employ a similar strategy to inhibit SG function.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Vicerrectorado de Investigación y Programa de doctorado "Biotecnología Avanzada"en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVirusen_US
dc.subject.otherPhytopathologyen_US
dc.subject.otherPlanten_US
dc.subject.otherGeminivirusen_US
dc.titleAnalyzing plant stress granules in response to plant virusesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleSeminario de Biotecnología Avanzadaen_US
dc.relation.eventplaceMálaga, Españaen_US
dc.relation.eventdate13 de diciembre 2018en_US


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