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dc.contributor.authorBernal Muñoz, Manuel
dc.date.accessioned2019-01-25T10:43:53Z
dc.date.available2019-01-25T10:43:53Z
dc.date.created2019
dc.date.issued2019-01-25
dc.identifier.urihttps://hdl.handle.net/10630/17209
dc.description.abstractCells are continuously exposed to different sources of DNA damage agents that can compromise genome stability. Double-strand break (DSB) is one of the most cytotoxic lesions, so faithful repair of DSB is critical to ensure cell viability. Repair of DSBs occurs by direct re-ligation of DNA ends through the non-homologous end-joining (NHEJ) pathway or by the homologous recombination (HR) pathway. Then, cells choose to activate any of these pathways according to their cell cycle progression. The HR pathway repairs the DSBs by using homologous DNA sequence as template for the broken chromosomes. This activity generates joint molecule (JM) intermediates during the different steps of the pathway. JM intermediates are sequentially matured into novel intermediates or dismantled by different specialized proteins (helicases and nucleases) to prevent their progression towards mitosis. Therefore, failure in resolving the JM intermediates results in chromosome segregation defects. Regarding mitochondrial DNA (mtDNA), DNA molecules are constantly damaged as the nuclear DNA and the mtDNA repair process needs to be coordinated with the nucleus activity. For that reason, the majority of the proteins needed for mtDNA repair are imported from the nucleus.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Fondos del presupuesto del Departamento de Biología Molecular y Bioquímica para ayudas a conferenciasen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectÁcido desoxirribonucleico mitocondrialen_US
dc.subject.otherHomologous recombinationen_US
dc.subject.otherDNA repairen_US
dc.subject.otherMitochondrial DNAen_US
dc.titleNuclear and mitochondrial homologous recombination process to repair DSB by nucleases and helicasesen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleConferencia invitada dirigida a estudiantes de máster y doctorado y a la comunidad científica en generalen_US
dc.relation.eventplaceMálaga, Españaen_US
dc.relation.eventdate15 de febrero de 2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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