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dc.contributor.authorÁvila Gámiz, Fabiola
dc.contributor.authorMañas Padilla, María del Carmen
dc.contributor.authorLadrón de Guevara Miranda, David
dc.contributor.authorGil Rodríguez, Sara
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorCastilla Ortega, Estela
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.date.accessioned2019-07-03T09:36:35Z
dc.date.available2019-07-03T09:36:35Z
dc.date.created2019
dc.date.issued2019-07-03
dc.identifier.urihttps://hdl.handle.net/10630/17932
dc.description.abstractModulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators of hippocampal plasticity enhancing neurogenesis. We aimed to evaluate whether a spatial learning task dependent on the hippocampus could reduce the long-term maintenance and reinstatement of these memories. Twenty male C57BL/6J mice were first trained in a cocaine induced conditioned place preference paradigm (CPP). Then, half of them (n=10) were trained in a spatial learning task using the Morris water maze, while the other half stayed in their home-cages. Twenty seven days after conditioning, mice were tested for CPP retention and extinction. Finally, a cocaine priminginduced reinstatement of drug seeking was performed. The results showed that animals trained in the spatial task exhibited a lower long-term CPP retention memory. In addition, it was observed an attenuation of cocaine-induced reinstatement of CPP by spatial training. Further studies could elucidate the biological mechanisms underlying these effects.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCocaínaen_US
dc.subjectAdicciónen_US
dc.subjectRatonesen_US
dc.subjectExtinción (Biología)en_US
dc.subjectPsicobiología -- Congresosen_US
dc.subject.otherCocaineen_US
dc.subject.otherAddictionen_US
dc.subject.otherConditioned place preferenceen_US
dc.subject.otherExtinctionen_US
dc.subject.otherMiceen_US
dc.titleEffect of a spatial memory training on the persistence of cocaine-contextual memoryen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Psicologíaen_US
dc.relation.eventtitleIII International Congress of Psychobiologyen_US
dc.relation.eventplaceGranada, Españaen_US
dc.relation.eventdate29/05/2019en_US


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