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Effect of a spatial memory training on the persistence of cocaine-contextual memory
dc.contributor.author | Ávila-Gámiz, Fabiola | |
dc.contributor.author | Mañas-Padilla, María del Carmen | |
dc.contributor.author | Ladrón de Guevara-Miranda, David | |
dc.contributor.author | Gil Rodríguez, Sara | |
dc.contributor.author | Rodriguez-de-Fonseca, Fernando | |
dc.contributor.author | Castilla-Ortega, María Estela | |
dc.contributor.author | Santín-Núñez, Luis Javier | |
dc.date.accessioned | 2019-07-03T09:36:35Z | |
dc.date.available | 2019-07-03T09:36:35Z | |
dc.date.created | 2019 | |
dc.date.issued | 2019-07-03 | |
dc.identifier.uri | https://hdl.handle.net/10630/17932 | |
dc.description.abstract | Modulation of hippocampal memories related with cocaine addiction such as cocaine-context associations could have important clinical implications. It has been shown that learning-related experiences are potent modulators of hippocampal plasticity enhancing neurogenesis. We aimed to evaluate whether a spatial learning task dependent on the hippocampus could reduce the long-term maintenance and reinstatement of these memories. Twenty male C57BL/6J mice were first trained in a cocaine induced conditioned place preference paradigm (CPP). Then, half of them (n=10) were trained in a spatial learning task using the Morris water maze, while the other half stayed in their home-cages. Twenty seven days after conditioning, mice were tested for CPP retention and extinction. Finally, a cocaine priminginduced reinstatement of drug seeking was performed. The results showed that animals trained in the spatial task exhibited a lower long-term CPP retention memory. In addition, it was observed an attenuation of cocaine-induced reinstatement of CPP by spatial training. Further studies could elucidate the biological mechanisms underlying these effects. | en_US |
dc.description.sponsorship | Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cocaína | en_US |
dc.subject | Adicción | en_US |
dc.subject | Ratones | en_US |
dc.subject | Extinción (Biología) | en_US |
dc.subject | Psicobiología -- Congresos | en_US |
dc.subject.other | Cocaine | en_US |
dc.subject.other | Addiction | en_US |
dc.subject.other | Conditioned place preference | en_US |
dc.subject.other | Extinction | en_US |
dc.subject.other | Mice | en_US |
dc.title | Effect of a spatial memory training on the persistence of cocaine-contextual memory | en_US |
dc.type | info:eu-repo/semantics/conferenceObject | en_US |
dc.centro | Facultad de Psicología y Logopedia | en_US |
dc.relation.eventtitle | III International Congress of Psychobiology | en_US |
dc.relation.eventplace | Granada, España | en_US |
dc.relation.eventdate | 29/05/2019 | en_US |