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dc.contributor.authorSoto-Navarrete, María Teresa
dc.contributor.authorFernández, M. Carmen
dc.contributor.authorLópez-Unzu, Miguel A.
dc.contributor.authorPozo-Vilumbrales, Bárbara
dc.contributor.authorDurán, Ana C.
dc.contributor.authorFernández-Corujo, Borja 
dc.date.accessioned2019-07-31T09:05:09Z
dc.date.available2019-07-31T09:05:09Z
dc.date.created2019-07-31
dc.date.issued2019-06
dc.identifier.citationSoto-Navarrete MT, Fernández MC, López-Unzu MA, Pozo-Vilumbrales B, Durán AC, Fernández B. J Morphol 2019, 280 (S1): S222en_US
dc.identifier.urihttps://hdl.handle.net/10630/18188
dc.description.abstractThe coronary arteries (CAs) supply the mammalian heart with oxygenated blood. They arise from the right and left aortic valve sinuses at the aortic root. In humans, the occurrence of a CA arising ectopically from the tubular aorta, a condition called high take-off (HTO), is rare (<0.4%) and predisposes to sudden cardiac death. We have shown that HTO is relatively frequent in some laboratory mouse strains, and preliminary studies suggests that the Smad2rs29725537:C>A (Smad2C>A) allele is associated with HTO in this species. In order to test whether HTO occurs in association with Smad2C>A in other rodents, we examined the anatomical origin of the CAs, by means of stereomicroscopy and a corrosion cast technique, in 3,388 specimens belonging to 17 rodent species. In addition, Smad2 DNA sequence from M. musculus was compared by Blastn analyses with that from six of the species examined in which this sequence is known (Mus spretus, Rattus norvegicus, Apodemus sylvaticus, Myodes glareolus, Mesocricetus auratus, Microtus agrestis). HTO occurred in nine out of 17 species studied. The incidence of HTO ranged from 0.4% to 6.5% (low) in three species and from 15.9% to 25% (high) in six species. The Smad2 sequence showed similarities higher than 75% for the whole gene, and higher than 71% for the intron sequence that includes the rs29725537:C>A Single Nucleotide Polymorphism. The Smad2C>A allele was identified only in M. spretus and A. sylvaticus, with high incidences of HTO, whereas R. norvegicus, M. glareolus, M. auratus and M. agrestis showed low or null incidences. We conclude that HTO is a common trait in rodents, which does not lead to cardiac pathology probably due to the intramyocardial condition of their CAs, as opposed to the human subepicardial CAs. The Smad2C>A allele may be involved in the development of HTO and probably other phenotypes in different rodent species.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Funding: CGL2017-85090-P, FPU15/03209, UMAJI75 and FEDER.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherCoronary arteriesen_US
dc.subject.otherrodentsen_US
dc.subject.otherhigh take-offen_US
dc.subject.otherSmad2en_US
dc.subject.otheranomalyen_US
dc.titleCoronary artery high take-off in rodents and the possible involvement of Smad2en_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleInternational Congress of Vetebrate Morphology 2019en_US
dc.relation.eventplacePraga, República Checaen_US
dc.relation.eventdate20-25 julio 2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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