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dc.contributor.authorLópez-Unzu, Miguel A.
dc.contributor.authorRodríguez, Cristina
dc.contributor.authorSoto-Navarrete, María Teresa
dc.contributor.authorFernández-Corujo, Borja 
dc.contributor.authorDurán, Ana C.
dc.date.accessioned2019-07-31T09:25:02Z
dc.date.available2019-07-31T09:25:02Z
dc.date.created2019-07-31
dc.date.issued2019-06
dc.identifier.citationLópez-Unzu MA, Rodríguez C, Soto-Navarrete MT, Fernández B, Durán AC. J Morphol 2019, 280 (S1): S168en_US
dc.identifier.urihttps://hdl.handle.net/10630/18190
dc.description.abstractThe formation of trabeculae (trabeculation) in vertebrates occurs during cardiac development in the three structural types of ventricular myocardium, namely, compact, spongy and mixed. The compact type is mainly composed of compacted muscular fibers and the spongy type of muscular trabeculae. The mixed type, with an inner trabecular and an outer compact layer, has been proposed as the primitive condition in gnathostomes. In vertebrate models, trabeculation initiates following two alternative mechanisms: (1) in chicken and mouse, the endocardial cells evaginate towards the two-layered myocardium; (2) in zebrafish, cardiomyocytes from the mono-layered myocardium invaginate towards the endocardium. Trabeculation in the mixed myocardium has not been described yet. We have studied the mixed myocardium formation in the dogfish (Scyliorhinus canicula, Elasmobranchii) using light, scanning and transmission electron microscopy. At stage 27, the ventricle consists of a two-layered myocardium internally lined by endocardium, both separated by cardiac jelly. Trabeculation starts at stage 28, when small spaces between cardiomyocytes appear, the cardiac jelly become thinner and the endocardium focally contacts the myocardium. At stage 29 the spaces between cardiomyocytes increase in size and get lined by the endocardium, shaping the presumptive trabeculae. At later stages, the trabeculae increase in complexity and the outer cardiomyocytes proliferate and get compacted, delineating the definitive trabeculated and compact myocardia. We conclude that early trabeculation in elasmobranchs matches that described in tetrapods. Thus, the mechanism of trabeculation of the mixed ventricular myocardium has been conserved in the formation of the compact myocardium of tetrapods. Additional studies in actinopterygians with different myocardial types may uncover how trabeculation has evolved during the evolution of gnathostomes.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. CGL2017-85090-P, FPU15/03209, UMAJI75 and FEDER.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.otherTrabeculationen_US
dc.subject.othermyocardiumen_US
dc.subject.otherchondrichthyansen_US
dc.subject.otherevolutionen_US
dc.subject.othergnathostomesen_US
dc.titleVentricular myocardial trabeculation in chondrichthyans. Evolutionary implicationsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleInternational Congress of Vetebrate Morphology 2019en_US
dc.relation.eventplacePraga, República Checaen_US
dc.relation.eventdate20-25 julio 2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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