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dc.contributor.authorNarváez, Manuel 
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorTif, Maria
dc.contributor.authorFuxe, Kjell
dc.contributor.authorBorroto-Escuela, Dasiel
dc.date.accessioned2019-09-11T09:02:44Z
dc.date.available2019-09-11T09:02:44Z
dc.date.created2019
dc.date.issued2019-09-11
dc.identifier.urihttps://hdl.handle.net/10630/18302
dc.description.abstractNeurogenesis persists in the hippocampus throughout the lifespan in a wide variety of species including humans. Within the dentate gyrus of the hippocampus, the subgranular zone (SGZ) is maintained as a stem cell niche. We have previously shown that Galanin (GAL) interacts with Neuropeptide Y Y1 receptors (NPYY1R) in several regions of the central nervous system associated with mood and motivation. To examine the acute effects of GALR2/NPYY1R interactions on newborn cells proliferation we analyzed the effects of the intracerebroventricular (icv) of single injections with GAL and NPYY1 agonists or coadministered. Male Sprague-Dawley rats (n = 6-8 per group) were randomly assigned to the groups. Each group received i.c.v. injections of artificial Cerebro Spinal Fluid (aCSF), GAL or NPYY1R agonist [Leu31,Pro34]NPY alone or in combination. Intraperitoneal (ip) injections of exogenous cell DNA marker 5-bromo-2-deoxyuridine (BrdU) 50mg/Kg were made at 2 and 4 hours after icv injections and 24 hours later rats were anesthetized, transcardially perfused and the brains collected for immunostaining to evaluate cell proliferation. Coadministration of GAL and NPYY1R agonist increased BrdU-labeled cells located in the SGZ (P<0,001) compared with aCSF, GAL and the NPYY1R-mediated hippocampal cell proliferation, These results will contribute to a better knowledge of the potential role of GAL and NPY family in mediating neurogenic actions and may give the basis for the therapeutic potential of targeting the GAL and NPY system in depressive disorders. Study supported by Proyecto Crowfunding “Más Neuronas, menos depression” Universidad de Málaga. Acknowledgements to Catalina, Héctor Pittman Villareal and Francisco Rodriguez López.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Proyecto Crowfunding “Más Neuronas, menos depression” Universidad de Málaga. Acknowledgements to Catalina, Héctor Pittman Villareal and Francisco Rodriguez López.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNeurogénesisen_US
dc.subject.otherGalaninen_US
dc.subject.otherNeuropeptide Yen_US
dc.subject.otherDepressionen_US
dc.titleImprovement on hippocampal neuroproliferation through galanin and neuropeptide y y1 receptor agonist interactionen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Medicinaen_US
dc.relation.eventtitleCongreso SENC 2019en_US
dc.relation.eventplaceSantiago de Compostelaen_US
dc.relation.eventdate4-09-2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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