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dc.contributor.authorLópez-González, Manuel Víctor 
dc.contributor.authorGonzález-García, Marta
dc.contributor.authorCarrillo-Franco, Laura
dc.contributor.authorCarrillo-Franco, Cristina
dc.contributor.authorDíaz-Casares, Amelia 
dc.contributor.authorBarbancho-Fernandez, Miguel Angel 
dc.contributor.authorDawid-Milner, Marc Stefan 
dc.date.accessioned2019-09-11T12:07:12Z
dc.date.available2019-09-11T12:07:12Z
dc.date.created2019
dc.date.issued2019-09-11
dc.identifier.urihttps://hdl.handle.net/10630/18317
dc.description.abstractBackground: Stimulation of the dorsomedial hypothalamic nucleus and perifornical area (DMH-PeF) in rats evokes a cardiorespiratory response characterised by an increase in blood pressure, heart rate and respiratory frequency. In previous studies (Díaz-Casares et al., 2012; López-González et al., 2018) we have shown a functional interaction between DMH-PeF and pontine structures (A5 region and Parabrachial Complex). We have also shown that rostral and ventral pontine structures are involved in the changes of laryngeal caliber (Lara et al., 2002). The aim of this study was to characterize the relations between hypothalamic and pontine neuronal circuits involved in laryngeal activity and its effect on vocalization. Methods: Experimental studies were carried out with non-inbred male rats (n=7). Animals were anesthetized with sodium pentobarbitone (60 mg/kg i.p., initial dose, supplemented 2 mg/ kg, i.v., as necessary). A double tracheal cannulation (upwards in direction of the glottis for the “glottis isolated in situ” technique) was done. Subglottic pressure was recorded with an aneroid transducer by passing a stream of humidified medical air upwards through the larynx at a constant rate of 30-70 ml/min with a thermal mass digital air flow meter controller. Electrical stimulation of the DMH-PeF using concentric bipolar electrodes (1 ms pulses, 20-40 µA, 100 Hz for 5 s) was performed. Respiratory flow, pleural pressure, blood pressure, heart rate and ECG activity were also recorded. Results: DMH-PeF stimulation evoked a decrease of laryngeal resistance (subglottal pressure) (p<0,001) accompanied with an inspiratory facilitatory response consisted of an increase in respiratory rate (p<0,001), together with a pressor (p<0,001) and a tachycardic response (p<0,001). Conclusions: The results of our study contribute with new data on the role of the DMH-PeF in the mechanisms controlling subglottic pressure and laryngeal activity.en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRespiraciónen_US
dc.subject.otherSubglottic Pressureen_US
dc.subject.otherLaryngeal Motoneuronsen_US
dc.subject.otherdorsomedial hypothalamic nucleus and perifornical areaen_US
dc.subject.otherRaten_US
dc.titleLaryngeal effects of stimulation of the dorsomedial hypothalamic nucleus and perifornical area in spontaneously breathing anaesthetized ratsen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Medicinaen_US
dc.relation.eventtitle18th National meeting of the Spanish Society of Neuroscienceen_US
dc.relation.eventplaceSantiago de Compostela, Españaen_US
dc.relation.eventdate04-09-2019en_US


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