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dc.contributor.authorCollado, Daniel 
dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.contributor.authorRuiz-Sanchez, Antonio Jesus
dc.contributor.authorMayorga, Cristobalina
dc.contributor.authorTorres-Jaen, Maria Josefa 
dc.date.accessioned2019-09-11T12:33:53Z
dc.date.available2019-09-11T12:33:53Z
dc.date.created2019
dc.date.issued2019-09-11
dc.identifier.urihttps://hdl.handle.net/10630/18321
dc.description.abstractBetalactams are the most widely utilized drugs against infections but are the primary cause of allergic reactions to antibiotic drugs. REF1 An accurate diagnosis of these allergic reactions to betalactams is crucial to avoid the use of unnecessary alternative antibiotics that may reduce efficacy, lead to prolonged treatments, have a higher toxicity or induce bacterial resistance. The most consensual approach to diagnose betalactam allergy are in vivo tests. However, they are not risky free, require experienced personnel and are both time-consuming and expensive for health-care systems, being so in vitro test more appropriate or complementary to the in vivo tests. In vitro tests are not still widely used on account of their low sensitivity. Current efforts are in progress to improve these assays, thus allowing for better diagnosis of allergic responses within patients. REF 2 We report progress in the preparation of new functional materials for in vitro allergic diagnosis testing. In particular, the application of new approaches employing orthogonally functionalised fluorescent dyes based upon 4-amino-1,8 naphthalimide joined with the multivalence of polyamide dendrimers. REF 3 The in vitro diagnosis capabilities of these functional materials was verified by testing on patient sera samples, with results demonstrating their potential for application within the healthcare industry. Acknowledgments: The present study has been supported by MINECO CTQ2016-75870P; by Andalusian Regional Ministry Health (grants: PI-0250-2016); by the European Regional Development Fund (ERDF) and “Plan Propio Universidad de Málaga” (UMA-Andalucía-TECH).en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlergia a los medicamentosen_US
dc.subject.otherDendrímerosen_US
dc.subject.otherAlergíaen_US
dc.subject.otherAmoxicilinaen_US
dc.titleNew Approaches in the Manufacture of Biomaterials for Betalactam Allergic Diagnoseen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitle5th World Congress on Electrical Engineering and Computer Systems and Sciencesen_US
dc.relation.eventplaceLisboaen_US
dc.relation.eventdate22/08/2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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