Mostrar el registro sencillo del ítem

dc.contributor.authorMañas-Padilla, M.C.
dc.contributor.authorGil-Rodriguez, Sara
dc.contributor.authorSampedro-Piquero, Patricia
dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.contributor.authorSantín, Luis J
dc.contributor.authorCastilla Ortega, Estela
dc.date.accessioned2019-10-01T11:08:14Z
dc.date.available2019-10-01T11:08:14Z
dc.date.created2019
dc.date.issued2019-10-01
dc.identifier.urihttps://hdl.handle.net/10630/18503
dc.description.abstractAims: Using a new animal model (‘chronic’ cocaine-induced conditioned place preference –CPP- paradigm), this work studied whether the long-term maintenance of cocaine-associated memories was concomitant to cognitive impairment and adult hippocampal neurogenesis (AHN) alterations. Methods: Male c57BL/6J mice were submitted to a CPP task treated either with cocaine (20 mg/kg/day) or saline for 14 days (n=10 per group). Bromodeoxyuridine (BrdU) was administered to label the new hippocampal neurons generated one week after the last cocaine dose. After 28 drug-free days, mice were assessed for the CPP memory and on a battery of emotional and cognitive behavioral tests. After completion of behavior, brains were collected for AHN analysis. Results: In mice treated with cocaine, preference for the cocaine-paired compartment (CPP memory) persisted over time. In addition, the cocaine-withdrawn mice overall displayed normal emotional behavior but they showed hippocampal-dependent cognitive impairment for novelty recognition (object and place) and spatial (reference and working) memory. The number of BrdU+ cells was unaffected, suggesting that cocaine withdrawal did not impair basal AHN. However, the cocaine-withdrawn mice excessively increased the number immature hippocampal neurons (doublecortin+) after behavioral training, in direct correlation with their cognitive performance, probably as a result of effortful learning. Conclusions: The CPP memory induced by cocaine remains unaltered after a prolonged period of abstinence, accompanied by defective acquisition of new learnings. Since the doublecortin+ neurons correlated with better cognitive performance in the cocaine-withdrawn mice, strategies that increase AHN could alleviate neurocognitive deficits induced by cocaine.en_US
dc.description.sponsorshipPlan Propio Universidad de Málaga Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectToxicomanía - Complicaciones y secuelasen_US
dc.subjectCocainaen_US
dc.subjectHipocampo (Cerebro)en_US
dc.subjectExperimentación animalen_US
dc.subject.otherCocaineen_US
dc.subject.otherNeurogenesisen_US
dc.subject.otherCognitionen_US
dc.titlePersistent drug-associated memories coexist with hippocampal-dependent cognitive decline and altered adult hippocampal neurogenesis in mice withdrawn from cocaine.en_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Psicologíaen_US
dc.relation.eventtitle48th Annual General Meeting of European Brain and Behaviour Society (EBBS)en_US
dc.relation.eventplacePragaen_US
dc.relation.eventdate21 a 24 de septiembre, 2019en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional