Mostrar el registro sencillo del ítem

dc.contributor.authorBenitez-Martin, Carlos
dc.contributor.authorGuadix, Juan Antonio
dc.contributor.authorPearson, John R.
dc.contributor.authorNajera-Albendin, Francisco 
dc.contributor.authorPerez-Pomares, Jose Maria 
dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.date.accessioned2019-10-25T07:26:09Z
dc.date.available2019-10-25T07:26:09Z
dc.date.created2019
dc.date.issued2019-10-25
dc.identifier.urihttps://hdl.handle.net/10630/18641
dc.description.abstractFluorescence-based biosensors have become an indispensable tool in modern biology. These molecules can be used to monitor processes inside living cells and in real-time. The control of the pH is crucial in multiple biological process such as proliferation, apoptosis and defense. Therefore, the use of such pH probes are widespread in fluorescence microscopy. Recently, we have described a biosensor with excellent photophysical and suitable two-photon absorption (TPA) properties. This sensor allows the detection of hydroxyl radicals inside lysosomes. Based on this scaffold, we have designed, synthesized and characterized a new TPA fluorescent probe with an “off-on” response to different pH environments. These naphthalene-indolenine derivatives have a high synthetic versatility through affordable and efficient synthesis. The preliminary results suggest that this sensor has promising properties for detecting pH changes inside living cells.en_US
dc.description.sponsorshipReal Sociedad Española de Química. Universidad de Murcia. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Techen_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiodetectoresen_US
dc.subjectMicroscopía de fluorescenciaen_US
dc.subjectSondas fluorescentesen_US
dc.subjectIones hidrógeno - Concentraciónen_US
dc.subject.otherPH probeen_US
dc.subject.otherTwo-photon absorptionen_US
dc.title“Off-on” two-photon indolenine probes for pH bioimagingen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.relation.eventtitleIX Reunión de Química Orgánica del Mediterráneoen_US
dc.relation.eventplaceMurcia (España)en_US
dc.relation.eventdate23/10/2019en_US


Ficheros en el ítem

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem