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    The effect of Galanin N-Terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.

    • Autor
      Millón-Peñuela, CarmeloAutoridad Universidad de Málaga; Flores-Burgess, AntonioAutoridad Universidad de Málaga; Gago-Calderón, BelénAutoridad Universidad de Málaga; García-Durán, LauraAutoridad Universidad de Málaga; Cantero-García, Noelia; Alén, Francisco; Orio, Laura; Narváez-Bueno, José ÁngelAutoridad Universidad de Málaga; Fuxe, Kjell; Santín-Núñez, Luis JavierAutoridad Universidad de Málaga; Díaz-Cabiale, ZaidaAutoridad Universidad de Málaga
    • Fecha
      2019-11-18
    • Palabras clave
      Neuropéptidos; Depresión - Tratamiento
    • Resumen
      The Galanin N-terminal fragment (1-15) [GAL(1-15)] induces depressant- and anxiogenic-like actions in behavioral tests and these effects were significantly stronger than the ones induced by Galanin. Since anhedonia is a core feature of depression, we have analyzed GAL(1-15) actions in two anhedonic-like behavior tests: saccharin Self-administration and Sucrose Preference test (SPT). In order to investigate whether the effect of GAL(1–15) was associated with the reward circuit, we have studied the GAL(1-15) actions over the mesolimbic system by the expression of the C-Fos, Dat, Vmat2 and Dopamine and GAL receptors genes in VTA and NAc. GAL(1-15) 3nmol significantly decreased the number of reinforcement of saccharin self-administer (p<0.01), while 1nmol lacked effect. GAL(1-15) also significantly reduced the number of reinforcement (p<0.01) compared with GAL. The GALR2 antagonist M871 significantly blocked (p<0.05) the decrease in the number of saccharin reinforcements induced by GAL(1-15). In the SPT, GAL(1-15) decreased the sucrose intake 8 (p<0.05) and 24 hours (p<0.01) after administration. GAL(1-15) at a dose of 3 nmol produced a significant decrease in the mRNA levels of Dat and Vmat2 (p<0.05) and an increase in the D3 receptor (p<0.05) in VTA. In the NAc, GAL(1-15) induced a significant decrease in the expression of C-Fos (p<0.05) mRNA and a significantly increased the mRNA expression of D1 (p<0.05), D2 (p<0.05) and D3 (p<0.05). In the current study, we described for the first time that GAL(1-15) induced a strong anhedonia-like phenotype in several behavioral tests, confirming an important role of this neuropeptide in anhedonia, moreover, the dopaminergic mesolimbic system was described as a key region in GAL(1-15)-mediated action on anhedonia. These results may give the basis for the development of novel therapeutic strategies using GAL(1-15) for treatment of depression and reward-related diseases.
    • URI
      https://hdl.handle.net/10630/18842
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    Ficheros
    Abstract SfN 2019 Chicago.pdf (123.8Kb)
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    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA
    REPOSITORIO INSTITUCIONAL UNIVERSIDAD DE MÁLAGA