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dc.contributor.authorRuiz-Sanchez, Antonio J.
dc.contributor.authorCollado, Daniel 
dc.contributor.authorMayorga, Cristobalina
dc.contributor.authorTorres, Maria J.
dc.contributor.authorPerez-Inestrosa, Ezequiel
dc.date.accessioned2020-10-01T09:00:01Z
dc.date.available2020-10-01T09:00:01Z
dc.date.created2020-09-23
dc.date.issued2020-10-01
dc.identifier.urihttps://hdl.handle.net/10630/19867
dc.description.abstractβ-lactams are the most widely drug prescribed against infections, but they are the most commonly reported medication allergy too. A correct diagnosis of these allergic reactions is crucial to avoid rejecting them by other more expensive broad-spectrum antibiotics, with potential risk factors for the development of multiple drug-resistant bacteria. [1] Skin testing is the most consensual approach to diagnose β-lactam allergy, but this in vivo test is not risky free and should be performed under strict hospital surveillance.[2] In vitro testing is not still widely used on account of their low sensitivity. We report the use of already haptenized fluorescent dendrimers [3] to control the preparation of materials for in vitro test, and their verification by testing on patient sera samples. This fluorescent dendrimer is obtained from a dye with two orthogonal functional groups suitable for click chemistry. [4] Acknowledgments: This work was supported by: MINECO CTQ2016-75870P, Andalusian Regional Ministry Health (PI-0250-2016); European Regional Development Fund and “Plan Propio Universidad de Málaga” (UMA-Andalucía-TECH).en_US
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDendrímerosen_US
dc.subjectAlergia a los medicamentosen_US
dc.subject.otherDendrimeren_US
dc.subject.otherMichel's additionen_US
dc.subject.otherAllergic drugen_US
dc.titleDirect characterization of functional materials by haptenized fluorescent dendrimers for in vitro allergic drug diagnoseen_US
dc.typeinfo:eu-repo/semantics/conferenceObjecten_US
dc.centroFacultad de Cienciasen_US
dc.relation.eventtitleNANOPT ONLINE CONFERENCE (NPTO2020)en_US
dc.relation.eventplaceOnlineen_US
dc.relation.eventdate23-24 septiembre 2020en_US
dc.rights.ccAttribution-NonCommercial-NoDerivatives 4.0 Internacional*


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional