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dc.contributor.authorGarcía-Durán, Laura
dc.contributor.authorCantero-García, Noelia
dc.contributor.authorFlores-Burgess, Antonio
dc.contributor.authorGago, Belén
dc.contributor.authorPuigcerver-Martinez, Araceli 
dc.contributor.authorNarváez, José Ángel 
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorMillón, Carmelo
dc.contributor.authorDíaz-Cabiale, Zaida
dc.date.accessioned2021-01-22T15:52:41Z
dc.date.available2021-01-22T15:52:41Z
dc.date.created2021-01
dc.date.issued2021-01-22
dc.identifier.urihttps://hdl.handle.net/10630/20828
dc.description.abstractThe selective serotonergic reuptake inhibitors (SSRIs) are the most commonly used for the treatment of major depression. Recently, we observed that the Galanin N-terminal fragment (1-15) [GAL(1-15)] enhances the antidepressant-like effects induced by Fluoxetine (FLX) in the forced swimming test (FST) (Flores-Burgess et al, 2017). Therefore, we have analyzed the ability of GAL(1-15) to enhance the behavioural effects of Escitalopram (ESC), other SSRIs, in the FST and the tail suspension test (TST). In the first set of experiments, groups of rats received three injections (23, 5 and 1 hour) before FST of two different doses of ESC (5mg/Kg or 7,5mg/Kg) or vehicle to perform a dose-response curve in the FST. Secondly, different groups of rats received three injections of ESC (7,5mg/Kg) and a single injection of a threshold dose of GAL(1-15) (1nmol) or aCSF 15 minutes before the FST and TST. In the dose-response curve, ESC 5 mg/kg and 7,5 mg/kg significantly increase the swimming time (p<0.05), while lacking effects over immobility time. The threshold dose of GAL(1-15) 1nmol enhanced the antidepressant-like effects mediated by ESC 7,5mg/Kg, decreasing the immobility (p<0.05) and increasing the swimming time (p<0.05) in the FST. In TST, no differences were found between the treatments. Our results indicate an interaction between GAL(1-15) and ESC in the FST and open up the possibility to use GAL(1-15) for a combination therapy with SSRIs as a depression treatment.es_ES
dc.description.sponsorshipThis study was supported by Spanish SAF2016-79008-P, PI-0083-2019 and UMA18-FEDERJA-008 Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectBiomedicina -- Investigaciónes_ES
dc.subject.otherEscitaloprames_ES
dc.subject.otherGalaninaes_ES
dc.subject.otherDepresiónes_ES
dc.titleGalanin (1-15) enhances the behavioural effects of escitalopram in the forced swimming test in ratses_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Medicinaes_ES
dc.relation.eventtitleFENSes_ES
dc.relation.eventplaceGlasgowes_ES
dc.relation.eventdateJulio 2020es_ES


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