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Listar Investigación por autor "Urdiales-Ruiz, Jose Luis"
Mostrando ítems 1-9 de 9
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A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, Jose Luis; Sanchez-Jimenez, Francisca Maria; Peñafiel, Rafael; [et al.] (2015-09-14)Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, Jose Luis; Sanchez-Jimenez, Francisca Maria; Peñafiel, Rafael; [et al.] (2015-09-04)Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, Jose Luis; Medina, Miguel Ángel; Montañez, Raúl (2017-08-29)It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Evaluation of metabolism and biosignaling in the angiogenic microenvironment as potential targets for therapeutic intervention
Medina, Miguel Ángel; Ocaña-Ocaña, Maria del Carmen; Martínez-Poveda, Beatriz; Carrillo, Paloma; Urdiales-Ruiz, Jose Luis; [et al.] (2017-08-29)The "re-discovery" of Warburg effect at the turn of the present millennium has been a key determinant of the current renewed interest on cancer metabolism. In fact, metabolic reprogramming has been identified as one of the ... -
Interacciones funcionales y estructurales de las poliaminas con otras aminas biógenas y membranas biológicas
Acosta-Andrade, Carlos (UMA Editorial, 2017)La poliaminas (PA) derivadas de la ornitina, esto es, putrescina (Put) espermidina (Spd) y espermina (Spm), son policationes alifáticos que se encuentran presentes en prácticamente todos los seres vivos, y son esenciales ... -
La enseñanza del metabolismo: retos y oportunidades
Medina, Miguel Ángel; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose; Valpuesta-Fernandez, Victoriano; Heredia-Bayona, Antonio; [et al.] (2017-12)Hemos estructurado los contenidos del libro en diversas secciones. La primera presenta el Proyecto en cuyo marco se ha gestado la iniciativa que ha conducido a la edición del presente libro. La segunda sección la hemos ... -
Sensitivity of polyamine metabolism to glucose deprivation is increased in neuroblastoma cells with N-myc amplification
Ruiz-Pérez, M. Victoria; Urdiales-Ruiz, Jose Luis; Sanchez-Jimenez, Francisca Maria; Medina, Miguel Ángel (2014-07-10)Ornithine-derived polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. Neuroblastoma, the most frequent extra-cranial solid tumor in children, harbors amplification of n-myc ... -
Structural and functional interaction between polyamine related molecules and biological membranes
Acosta-Andrade, Carlos; Artetxe, I; Lete, MG; Ruiz-Mirazo, Kepa; Goñi, Félix; [et al.] (2016-09-22)Changes induced by PA on nucleic acid (NA) conformation and synthesis is proven to be a major reason for PA essentiality (1-3). However, PA interactions with other polyanions, for instance polyanionic membrane lipid bilayers ... -
Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles
Medina, Miguel Ángel; García-Ponce, Ángel Luis; Blanco-Lopez, Angel; Quesada, Ana R.; Urdiales-Ruiz, Jose Luis; [et al.] (ACS, 2022-05-25)Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on ...