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Listar Investigación por autor "Macías-González, Manuel"
Mostrando ítems 1-5 de 5
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8-oxoguanine DNA glycosylase 1 upregulation as a risk factor for obesity and colorectal cancer
Pilo, Jesus; García-Flores, Libia Alejandra; Clemente-Postigo, María Mercedes; Arranz-Salas, Isabel María; Alcaide, Julia; Ramos-Fernandez, Maria; Lozano-Castro, José; Boughanem Lakhal, Hatim; Kompella, Pallavi; Macías-González, Manuel[et al.] (MDPI, 2023-03-13)DNA damage has been extensively studied as a potentially helpful tool in assessing and preventing cancer, having been widely associated with the deregulation of DNA damage repair (DDR) genes and with an increased risk of ... -
Alteraciones del perfil epitranscriptómico (m6A) asociadas a mecanismos biológicos del cáncer colorrectal y obesidad.
Rego, Alejandro; Pilo, Jesús; García-Flores, Libia Alejandra; Boughanem, Hatim; Martín Nuñez, Gracia Maria; Macías-González, Manuel[et al.] (2023-11-24)La obesidad considerada un factor de riesgo crucial en el inicio y progresión del cáncer colorrectal, podría promover un microentorno favorable a la carcinogénesis mediado por alteraciones epitranscriptómicas, como la ... -
Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study
Linares-Pineda, Teresa María; Boughanem Lakhal, Hatim; Gutiérrez Repiso, Carolina; Macías-González, Manuel; Andrés-León, Eduardo; Rojo-Martínez, Gemma; Valdés, Sergio[et al.] (Wiley, 2022-03-28)Obesity has become a worldwide health problem, in which latest statistics reported an increased trend over the last years. Accordingly, long-term obesity is involved in an increased risk of developing several metabolic ... -
Study of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesity
Rego, Alejandro; Pilo, Jesús; García-Flores, Libia Alejandra; Boughanem, Hatim; Martín Nuñez, Gracia Maria; Macías-González, Manuel[et al.] (2023-12-01)Although the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and ... -
The emergent role of mitochondrial RNA modifications in metabolic alterations
Boughanem Lakhal, Hatim; Böttcher, Yvonne; Tomé-Carneiro, João; López de las Hazas, María-Carmen; Dávalos, Akin Cayir; Macías-González, Manuel[et al.] (Wiley, 2022-07-25)Mitochondrial epitranscriptomics refers to the modifications occurring in all the different RNA types of mitochondria. Although the number of mitochondrial RNA modifications is less than those in cytoplasm, substantial ...