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dc.contributor.authorLeón Rodríguez, Ana
dc.contributor.authorFernandez Arjona, Maria Del Mar
dc.contributor.authorPedraza-Benítez, Maria del Carmen 
dc.contributor.authorGrondona, Jesus M
dc.contributor.authorLopez Avalos, Maria Dolores
dc.contributor.authorLeón Rodríguez, Ana
dc.date.accessioned2021-07-20T12:02:40Z
dc.date.available2021-07-20T12:02:40Z
dc.date.issued2021-07
dc.identifier.urihttps://hdl.handle.net/10630/22662
dc.description.abstractA single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some of these symptoms decline with time along with inflammation, the possibility of long-term sequelae should be considered. Thus, we aimed to explore if NA-induced neuroinflammation provokes behavioral or neurological disturbances at medium (2 weeks) and long (10 weeks) term. Rats were ICV injected with NA or saline. First, neurological alterations of the sensorimotor reflexes were not found, suggesting that NA does not cause disturbances in major brain functions. While the open field test revealed normal locomotor capacity in the animals injected with NA, however the evaluation of specific behaviors (rearing and rearing with support) pointed out an increased anxiety state 2 weeks after NA administration, but not at long term (10 weeks). A histological study of brain areas related to emotions (amygdala) and stress response (hypothalamic PVN) revealed no significant differences in the number of microglia or astrocytes. Nevertheless, the morphological analysis of microglial cells demonstrated that, in the amygdala of NA injected rats, microglia presented a morphology consistent with a slightly activated state. Such morphological change, which was evident 2 weeks after NA injection, was virtually reverted 10 weeks post-ICV. These results point out that NA injected ICV may cause anxiety in the medium term (while not affecting other functions like sensorimotor functions or the locomotor capacity), a behavioral alteration that is transient and that concurs with a mild inflammation, evidenced by the overexpression of certain genes and, more notably, by the morphological bias of microglial cells located in the amygdala towards an activated profile.es_ES
dc.description.sponsorshipUniversidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.es_ES
dc.language.isoenges_ES
dc.publisherWiley Periodicals, LLCes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectNeuroinflamaciónes_ES
dc.subject.otherMicrogliaes_ES
dc.subject.otherNeuroinflammationes_ES
dc.subject.otherNeuraminidasees_ES
dc.subject.otherAnxietyes_ES
dc.titleAnxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammationes_ES
dc.typeinfo:eu-repo/semantics/conferenceObjectes_ES
dc.centroFacultad de Cienciases_ES
dc.relation.eventtitleXV European Meeting on Glial Cells in Health and Diseasees_ES
dc.relation.eventplaceVirtual conferencees_ES
dc.relation.eventdate05-09 Julio 2021es_ES


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