Biología Celular, Genética y Fisiología - (BCGF)
Estas son las colecciones en las que puede catalogar la producción investigadora del departamento Biología Celular, Genética y Fisiología. Si considera que ninguna de estas se ajusta a su material pida una nueva colección en la sección de sugerencias.
Colecciones en esta comunidad
Envíos recientes
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Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
(Springer Nature, 2016-10-14)El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
(IOS Press, 2010-07-08)Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Heterogeneidad regional de la respuesta microglial asociada a la patología amiloide en la enfermedad de Alzheimer.
(UMA Editorial, 2024)La enfermedad de Alzheimer (AD), principal causa de demencia y discapacidad, es la patología neurodegenerativa más prevalente en los mayores de 65 años y para la cual no existe un tratamiento efectivo. Se trata de una ... -
Emerging viruses infecting solanaceous crops: genetic characterization of the pepper vein yellows virus complex and generation of tomato chlorosis virus infectious clones.
(UMA Editorial, 2024)Los virus son las entidades biológicas más abundantes en la Tierra, infectan a miembros de los tres superreinos de la vida (Bacterias, Arqueas y Eukarya) y sus pequeños genomas los obligan a ser parásitos intracelulares. ... -
Geminiviruses: molecular and genetic characterization of their interaction with the plant.
(UMA Editorial, 2024)Esta tesis se centra en el estudio de la interacción de los geminivirus con su hospedador. Los geminivirus son una familia de pequeños virus no envueltos con genomas que comprenden uno o dos ADN circulares de cadena sencilla ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
(BMC, 2020-03-17)In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
(MDPI, 2022-08-06)Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably ... -
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
(Springer, 2021-08-24)Background Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the ... -
Squamous cell carcinoma related with dental implants. A clinical cases report.
(Medicina Oral S.L., 2020-01)One third of all cases of head and neck carcinoma (CA) concern the oral mucosa. The use of dental implants (DI) for dental rehabilitation is widely extended. However, a few studies have reported some cases with neoplasic ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
(MDPI, 2020-04-01)Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
(MDPI, 2020-08-11)The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
Estudio de la sumoilación en el papel de la proteína Rep en el replisoma viral
(UMA Editorial, 2024)Los geminivirus son una familia de virus transmitidos por insectos que infectan numerosas especies vegetales de gran interés agrícola en regiones con clima tropical y subtropical de todo el mundo, ocasionando grandes ... -
Surface nitridation improves bone cell response to melt-derived bioactive silicate/borosilicate glass composite scaffolds
(ELSEVIER, 2016-01-01)Novel bioactive amorphous glass-glass composite scaffolds (ICIE16/BSG) with interconnected porosity have been developed. Hierarchically interconnected porous glass scaffolds were prepared from a mixture of two melt-derived ... -
Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity.
(British Society for Plant Pathology, 2021-04-01)Chitin is a major structural component of fungal cell walls and acts as a microbe- associated molecular pattern (MAMP) that, on recognition by a plant host, triggers the activation of immune responses. To avoid the activation ... -
The interspecific fungal hybrid Verticillium longisporum displays subgenome-specific gene expression
(American Society for Microbiology, 2021-08)Hybridization is an important evolutionary mechanism that can enable organisms to adapt to environmental challenges. It has previously been shown that the fungal allodiploid species Verticillium longisporum, the causal ... -
Study of the impact of m6A RNA methylation in altered molecular mechanisms in colorectal cancer and its association with obesity
(2023-12-01)Although the etiology of colorectal cancer (CRC) is multifactorial and complex, due to the interaction of altered environmental and genetic mechanisms, obesity is considered a crucial risk factor in the initiation and ... -
Geminivirus Replication Protein impairs SUMO conjugation of PCNA at two acceptor sites.
(ASM Journals, 2018-06-27)Geminiviruses are DNA viruses that replicate in nuclei of infected plant cells using the plant DNA replication machinery, including PCNA (proliferating cellular nuclear antigen), a cofactor that orchestrates genome duplication ... -
Transfer and engineering of immune receptors to improve recognition capacities in crops
(Elsevier Ltd, 2017-08)Immune receptors are pivotal elements of the plant immune system that act as sentinels for microbial invasion. Knowingly or unknowingly, breeding for resistance has largely relied on the transfer of immune receptor recognition ... -
Alteraciones del perfil epitranscriptómico (m6A) asociadas a mecanismos biológicos del cáncer colorrectal y obesidad.
(2023-11-24)La obesidad considerada un factor de riesgo crucial en el inicio y progresión del cáncer colorrectal, podría promover un microentorno favorable a la carcinogénesis mediado por alteraciones epitranscriptómicas, como la ... -
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
(Public Library of Science, 2020-06-23)Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, many fungal pathogens secrete LysM ...