Biología Celular, Genética y Fisiología - (BCGF)
Estas son las colecciones en las que puede catalogar la producción investigadora del departamento Biología Celular, Genética y Fisiología. Si considera que ninguna de estas se ajusta a su material pida una nueva colección en la sección de sugerencias.
Colecciones en esta comunidad
Envíos recientes
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Microglial and neurogenic alterations in hypothalamus due to acute stress
(2021-07)Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ... -
Anxiety and mild microglial activation in the amygdala two weeks after NA-induced neuroinflammation
(Wiley Periodicals, LLC, 2021-07)A single injection of neuraminidase (NA) within the cerebral ventricles (ICV) triggers an acute neuroinflammation. Neurological complications or behavioral alterations have been associated to neuroinflammation. While some ... -
Coexistance of different damage-associated myeloid populations in the hippocampus of Alzheimer's patients
(Wiley, 2021)Parenchymal microglia are the brain-resident immune cells capable of responding to damage. Though the role of microglial cells in the development/progression of AD is still unknown, a dysfunctional response has recently ... -
La rizobacteria Pseudomonas alcaligenes AVO110 induce la expresión de genes relacionados con formación de biofilms en respuesta a exudados de Rosellinia necatrix
(2021-06)La rizobacteria Pseudomonas alcaligenes AVO110 muestra antagonismo frente al hongo fitopatógeno Rosellinia necatrix. Esta cepa coloniza eficazmente las hifas de R. necatrix y es capaz de alimentarse de sus exudados. ... -
The bacterial effector HopZ1a acetylates MKK7 to suppress plant immunity
(Wiley, 2021)The Pseudomonas syringae type III secretion system translocates effector proteins into the host cell cytosol to suppress plant basal immunity. Effector HopZ1a suppresses local and sys- temic immunity triggered by ... -
Suitability of human-derived cells as a platform for Alzheimer's disease modeling
(2021)Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
(Cold Spring Harbor Laboratory, 2020-12-02)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
(2021-03-09)Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
(UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Papel de los efectores tipo III en la especificidad de huésped de los patovares de Pseudomonas savastanoi
(UMA Editorial, 2021-02-17)La especie Pseudomonas savastanoi está constituida por cuatro patovares que causan tumores o excrecencias en huéspedes leñosos: pv. savastanoi (Psv), pv. nerii, pv. fraxini y pv. retacarpa, constituidos por cepas aisladas ... -
Small RNAs and plant defense: from functional characterisation to tool development
(UMA Editorial, 2021-01-16)Las plantas codifican para una batería de receptores intracelulares conocidos como genes de Resistencia o NLRs (nucleotide-binding leucine-rich repeat receptors), que reconocen a proteínas efectoras y disparan una respuesta ... -
Biosíntesis de auxinas y papel de ácido indol-3-acético como molécula señal en Pseudomonas savastanoi: aproximación genómica, transcriptómica y metabolómica
(UMA Editorial, 2021-02-11)El complejo Pseudomonas syringae esta formado por un amplio número de bacterias fitopatógenas clasificadas en 65 patovares y 15 especies, entre las que se encuentra Pseudomonas savastanoi. Las cepas de P. savastanoi producen ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
(2020-12-18)Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
(2020-12-17)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
(2020-12-17)Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
(2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Elaboración de cervezas, del pasado al presente
(2020-11-03)La elaboración de cerveza es considerado el proceso biotecnológico más antiguo, en el que se requiere la extracción y modificación de azúcares del grano de cereal por parte de enzimas naturales y la posterior transformación ...