Biología Celular, Genética y Fisiología - (BCGF)
Estas son las colecciones en las que puede catalogar la producción investigadora del departamento Biología Celular, Genética y Fisiología. Si considera que ninguna de estas se ajusta a su material pida una nueva colección en la sección de sugerencias.
Colecciones en esta comunidad
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Suitability of human-derived cells as a platform for Alzheimer's disease modeling
(2021)Aims: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. Recently, ... -
18F-THK5351 PET imaging, neuropathology and clinical progression in a tau mouse model
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. The neuropathology of AD is characterized by the extracellular deposition of ... -
Microtubule stabilization reduces amyloid pathology and improves synaptic/memory deficits in APP/PS1 mice
(Alzheimer disease & Parkinson disease Conference 2021, 2021)Aims: Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic/neuronal loss. Tau hyperphosphorylation destabilizes microtubules leading to axonal transport failure and generation of dystrophic neurites, ... -
Amyloid-β seeding and propagation processes in a hAβ-KI model of Alzheimer's disease
(Cold Spring Harbor Laboratory, 2020-12-02)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Understanding microglial responses in the frontal cortex of alzheimer´s disease patients
(2021-03-09)Microglial cells, the immune cells of the brain, and the neuroinflammatory process associated, have been postulated as a critical factor in AD pathogenesis, since the identification of genetic risk factors related ... -
Contribución de la patología tau al proceso neuroinflamatorio y degenerativo en la enfermedad de Alzheimer: estudio en modelos animales transgénicos
(UMA Editorial, 2021-02-18)La enfermedad de Alzheimer (EA) es la proteinopatía neurodegenerativa más prevalente y para la que no existe ningún tratamiento. Se caracteriza por la acumulación cerebral de péptido beta-amiloide (Aβ) en forma de placas ... -
Papel de los efectores tipo III en la especificidad de huésped de los patovares de Pseudomonas savastanoi
(UMA Editorial, 2021-02-17)La especie Pseudomonas savastanoi está constituida por cuatro patovares que causan tumores o excrecencias en huéspedes leñosos: pv. savastanoi (Psv), pv. nerii, pv. fraxini y pv. retacarpa, constituidos por cepas aisladas ... -
Small RNAs and plant defense: from functional characterisation to tool development
(UMA Editorial, 2021-01-16)Las plantas codifican para una batería de receptores intracelulares conocidos como genes de Resistencia o NLRs (nucleotide-binding leucine-rich repeat receptors), que reconocen a proteínas efectoras y disparan una respuesta ... -
Biosíntesis de auxinas y papel de ácido indol-3-acético como molécula señal en Pseudomonas savastanoi: aproximación genómica, transcriptómica y metabolómica
(UMA Editorial, 2021-02-11)El complejo Pseudomonas syringae esta formado por un amplio número de bacterias fitopatógenas clasificadas en 65 patovares y 15 especies, entre las que se encuentra Pseudomonas savastanoi. Las cepas de P. savastanoi producen ... -
Human pluripotent stem cells as a research tool for elucidating the role of glial cells in Alzheimer´s disease
(2020-12-18)Background: Alzheimer's disease (AD) is characterized by presenting a complex pathology, not fully resolved yet. This fact, together with the lack of reliable models, has impeded the development of effective therapies. ... -
Amyloid-b seeding and propagation processes in a hAb-KI model of Alzheimer's disease
(2020-12-17)Recent evidence indicates that Aβ can misfold and aggregate into seeds that structurally corrupt native proteins, mimicking a prion-like process. Several studies using FAD animal models have demonstrated that ... -
Microtubule stabilization protects cognitive function and slows down the course of Alzheimer's like pathology in an amyloidogenic mouse model
(2020-12-17)Cognitive decline in Alzheimer's disease (AD) is highly related to synaptic dysfunction and neuronal loss. In AD, the hyperphosphorylation of tau compromises axonal transport and leads to the generation of dystrophic ... -
Coexistance of different myeloid populations in the frontal cortex of alzheimer's disease patients
(2020-12-16)Parenchymal microglia, the brain-resident immune cells capable of responding to damage and disease, has been postulated as a critical factor in the Alzheimer´s disease (AD) progression. Apart from microglia, CNS macrophages, ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Elaboración de cervezas, del pasado al presente
(2020-11-03)La elaboración de cerveza es considerado el proceso biotecnológico más antiguo, en el que se requiere la extracción y modificación de azúcares del grano de cereal por parte de enzimas naturales y la posterior transformación ... -
Characterization of an ibuprofen-eater bacteria
(2020-10-16)The presence of pharmaceutical compounds (PhCs) in drinking water, treated wastewater, groundwater, surface water, and soil around the world is an emerging challenge. The bioremediation of organic pollutants by microbial ... -
Detection of novel antimicrobial resistance genes in oil contaminated soils by metagenomic functional analysis
(2020-10-16)Our ability to cure infections that were once considered benign or of low risk is at stake due to the development and spread of antimicrobial resistance mechanisms (AMR). One of the measures proposed to fight this problem ... -
Implicación del receptor dopaminérgico D4 en la adicción a morfina
(UMA Editorial, 2020-09-30)La adicción es un trastorno asociado a un comportamiento compulsivo de consumo de drogas, en el que se produce una activación de las vías dopaminérgicas. El consumo prolongado desencadena un proceso de neuroadaptación. La ... -
Mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia
(2020-09-24)In addition to its structural role in skeletogenesis, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Aplicación de una terapia celular basada en células madre mesenquimales en un modelo animal de hidrocefalia congénita
(UMA Editorial, 2020-01-08)La hidrocefalia congénita es una condición patológica caracterizada por la acumulación de líquido cefalorraquídeo, con unas manifestaciones fisiopatológicas que incluyen: dilatación de los ventrículos cerebrales ...