Listar Biología Celular, Genética y Fisiología - (BCGF) por título
Mostrando ítems 258-277 de 423
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Late-life depression accelerates cognitive decline in a tauopathy mouse model
(IBRO/FENS, 2023)Background: Clinical studies suggest that depressive symptoms could be considered an important risk factor for the future development of cognitive impairment and even Alzheimer's disease (AD). In fact, there is a strong ... -
Late-life depression accelerates cognitive impairment and tau-associated pathology in an Alzheimer´s disease model.
(2023)Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Late-life depression is able to accelerate learning and memory impairment in a mouse model of Alzheimer´s disease
(CSHL, 2022)Clinical studies suggest that depression could be considered an important risk factor for the future development of cognitive impairment and Alzheimer's disease (AD). In fact, there is a strong association between late-life ... -
Lithium, as a neuroprotective therapy for Alzheimer’s disease pathology, modifies abeta plaque toxicity
(2014-07-02)BACKGROUND: Despite the relatively large information about the Alzheimer’s disease (AD) pathology, no effective disease-modifying treatment has been yet developed. Lithium, a primary drug to treat bipolar disorder, has ... -
Litio como terapia neuroprotectora en el modelo APPSL/PS1M146L de la enfermedad de Alzheimer.
(2013)El litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD). ... -
Logros y Retos de la Investigación en la Enfermedad de Alzheimer
(2014-11-28)La Enfermedad de Alzheimer es la principal causa de demencia actualmente en la población mayor de 80 años. A pesar del enorme esfuerzo investigador en este área, actualmente no conocemos ni las causas que lo originan ni ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
(Wiley, 2022-05-22)Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Long-time effects of an experimental therapy with mesenchymal stem cells in congenital hydrocephalus
(2019-07-03)Introduction: Bone marrow-derived mesenchymal stem cells (BM-MSC) are a potential therapeutic tool due to their ability for migrating and producing neuroprotector factors when they are transplanted in other neurodegenerative ... -
Longitudinal assessment of tau pet imaging and its correlation with neuropathology and clinical signs progression
(Cold Spring Harbor Laboratory, 2020-12-02)Alzheimer’s disease (AD) and other associated dementias remain a consistent and unruly problem for the aging population and health. As the world’s population increases, so does the prevalence of age-related dementias. The ... -
Manejo de parámetros ambientales en acuicultura
(2014-11-18)En la acuicultura se tiende a la optimización de la producción. Para ello se tiende a: i) conseguir una reproducción en cautividad de la especie cultivada, con el objetivo de asegurarse un suministro constante de larvas ii) ... -
Marcadores de imagen cerebral de diferentes trayectorias de envejecimiento
(2017-05-22)La enfermedad de Alzheimer (EA) es la demencia neurodegenerativa con mayor incidencia a partir de los 65 años. Esta enfermedad progresa desde fases preclínicas (asintomáticas) hacia fases prodrómicas (deterioro cognitivo ... -
Mecanismos básicos de osmorregulación en peces en diferentes salinidades. Aplicaciones del conocimiento de la omorregulación en peces al cultivo de especies de interés comercial
(2022-10)Los peces son animales osmorreguladores, es decir, mantienen su osmolaridad corporal regulada y diferenciada de la del medio acuático que habitan. Las estrategias osmorreguladoras van a ser totalmente diferentes en función ... -
Mecanismos de plasticidad sináptica en sinapsis neocorticales en desarrollo
(2015-11-04)Spike timing-dependent plasticity (STDP) is a strong candidate for an N-methyl-D-aspartate (NMDA) receptor-dependent form of synaptic plasticity that could underlie the development of receptive field properties in sensory ... -
Mecanismos epigenéticos que controlan la expresión del genoma en plantas
(2014-10-17)Borrando la memoria celular: mecanismos de desmetilación del ADN La metilación de DNA desempeña un papel esencial durante el desarrollo y la diferenciación celular, así como en la defensa del genoma frente a elementos ... -
Metabolite fingerprint detected with HR-MAS spectroscopy in ex vivo samples of cases with congenital hydrocephalus
(2014-07-16)Background: Changes in the profile of metabolites in brain and/or fluids can be useful to evaluate the severity and evolution of hydrocephalus, and consequently to help in treatment decisions. Magnetic Resonance Spectroscopy ... -
A metabolite profile reveals the presence of neurodegenerative conditions according to severity of hydrocephalus
(2018-11-29)Introduction: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage and astrocytic reaction. ... -
Metagenomic functional analysis as a tool to detect bacterial genes conferring resistance to clinical antibiotics in soils
(2022)The spread of antibiotic resistance genes has become a global health concern identified by the World Health Organization as one of the greatest threats to health. Many of antimicrobial resistance determinants found in ... -
Methylases and methylation in gene regulation in Pseudomonas syringae
(2022-07-03)DNA methylation carried out by methyltransferases not associated with restriction enzymes, known as orphan methyltransferases, is an epigenetic mechanism widely spread in bacteria and archea. These orphan methylases show ... -
Metilasas y metilación en la regulación génica de Pseudomonas syringae
(2022)La metilación del ADN llevada a cabo por metilasas no asociadas a enzimas de restricción, conocidas como metilasas huérfanas, es un mecanismo epigenético ampliamente extendido en bacterias y archeas. La especificidad de ... -
Microglial and neurogenic alterations in hypothalamus due to acute stress
(2021-07)Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous ...