BCGF - Artículos
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Therapeutic strategies to recover ependymal barrier after inflammatory damage: relevance for recovering neurogenesis during development.
(Frontiers, 2023)The epithelium covering the surfaces of the cerebral ventricular system is known as the ependyma, and is essential for maintaining the physical and functional integrity of the central nervous system. Additionally, the ... -
A selective defect in the glial wedge as part of the neuroepithelium disruption in hydrocephalus development in the mouse hyh model is associated with complete corpus callosum dysgenesis.
(Frontiers, 2024-02-21)INTRODUCTION Dysgenesis of the corpus callosum is present in neurodevelopmental disorders and coexists with hydrocephalus in several human congenital syndromes. The mechanisms that underlie the etiology of congenital ... -
Design of a Stem Cell-Based Therapy for Ependymal Repair in Hydrocephalus Associated With Germinal Matrix Hemorrhages
(AHA/ASA Journals, 2024-04)BACKGROUND: In preterm birth germinal matrix hemorrhages (GMHs) and the consequent posthemorrhagic hydrocephalus (PHH), the neuroepithelium/ependyma development is disrupted. This work is aimed to explore the possibilities ... -
El sistema CRISPR/Cas, un poderoso aliado en la lucha contra los organismos fitopatógenos
(Sociedad Española de Fitopatología, 2018)En la última década se han desarrollado varios sistemas para la edición génica, todos ellos basados en el uso de proteínas de unión a secuencias específicas de DNA, denominadas nucleasas específicas de secuencia (SSN): ... -
Characterization of rhizobia from Sesbania species native to seasonally wetland areas in Uruguay
(Springer Nature, 2008-03-27) -
Impaired Peripheral Lymphatic Function and Cerebrospinal Fluid Outflow in a Mouse Model of Alzheimer's Disease
(Sage Journals, 2019)Cerebrospinal fluid (CSF) outflow from the brain occurs through absorption into the arachnoid villi and, more predominantly, through meningeal and olfactory lymphatics that ultimately drain into the peripheral lymphatics. ... -
Novel Template Plasmids pCyaA’-Kan and pCyaA’-Cam for Generation of Unmarked Chromosomal cyaA’ Translational Fusion to T3SS Effectors in Salmonella
(MDPI, 2021-02-25)The type III secretion systems (T3SS) encoded in pathogenicity islands SPI-1 and SPI-2 are key virulence factors of Salmonella. These systems translocate proteins known as effectors into eukaryotic cells during infection. ... -
Dual-Fluorescence Chromosome-Located Labeling System for Accurate In Vivo Single-Cell Gene Expression Analysis in Pseudomonas syringae.
(Humana Press (Springer Group), 2024-01-25)Epigenetic regulation as a means for bacterial adaptation is receiving increasing interest in the last decade. Significant efforts have been directed towards understanding the mechanisms giving raise to phenotypic heterogeneity ... -
Induction of IAPP amyloid deposition and associated diabetic abnormalities by a prion-like mechanism
(Rockefeller University PRess, 2017)Although a large proportion of patients with type 2 diabetes (T2D) accumulate misfolded aggregates composed of the islet amyloid polypeptide (IAPP), its role in the disease is unknown. Here, we show that pancreatic IAPP ... -
PipB2 is a substrate of the Salmonella pathogenicity island 1- encoded type III secretion system
(Elvervier, 2012-06-29)Salmonella harbors two type III secretion systems, T3SS1 and T3SS2, encoded on the pathogenicity islands SPI1 and SPI2, respectively. Several effector proteins are secreted through these systems into the eukaryotic host ... -
The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling
(American Association for the Advancement of Science, 2018-09-19)Studies have suggested a role for the mammalian (or mechanistic) target of rapamycin (mTOR) in skeletal development and homeostasis, yet there is no evidence connecting mTOR with the key signaling pathways that regulate ... -
Mechanisms regulating auxin action during fruit development
(Wiley Online Library, 2013-12-16)Auxin controls many aspects of fruit development, including fruit set and growth, ripening and abscission. However, the mechanisms by which auxin regulates these processes are still poorly understood. While it is generally ... -
Two strawberry miR159 family members display developmental specific expression patterns in the fruit receptacle and cooperatively regulate Fa-GAMYB
(Wiley, 2012-02-26)We have reported previously that the gibberellin (GA) content in strawberry receptacle is high, peaking at specific stages, pointing to a role of this hormone in fruit development. In Arabidopsis, miR159 levels are dependent ... -
Gibberellin biosynthesis and signalling during development of the strawberry receptacle
(Wiley, 2011-07-19)Essential factors controlling the growth and development of strawberry (Fragaria × ananassa) fruit are poorly characterized at the molecular level. The roles played by different hormones in these processes remain largely ... -
The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo
(Springer Nature, 2017)Prion diseases are fatal neurodegenerative disorders affecting several mammalian species, characterized by the accumulation of the misfolded form of the prion protein, which is followed by the induction of endoplasmic ... -
Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
(Sage, 2009-11-12)Here we demonstrated that extracellular, not intracellular, Aβ and the associated cytotoxic glial neuroinflammatory response are major contributors of early neuronal loss in a PS1xAPP model. A significant loss of principal ... -
Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis.
(American Academy of Neurology, 2023-05-05)Background and objectives: Anti-NMDA receptor (NMDAR) encephalitis is defined by the presence of antibodies (Abs) targeting the NMDAR in the CSF. This study aimed to determine the prognostic value of persistent CSF NMDAR-Abs ... -
The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease
(Cell Death and Differentiation, 2020)Parkinson’s disease (PD) is the second most common neurodegenerative condition, characterized by motor impairment due to the progressive degeneration of dopaminergic neurons in the substantia nigra and depletion of dopamine ... -
Traumatic brain injury induces tau aggregation and spreading.
(Mary Ann Liebert Inc., 2020)The misfolding and aggregation of tau protein into neurofibrillary tangles is the main underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be associated with multiple risk factors. Traumatic ... -
Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo.
(Springer Nature, 2018)Transmissible spongiform encephalopathies (TSEs) are fatal neurological disorders caused by prions, which are composed of a misfolded protein (PrP Sc) that self-propagates in the brain of infected individuals by converting ...