BCGF - Artículos
Envíos recientes
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Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
(Springer Nature, 2016-10-14)El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
(IOS Press, 2010-07-08)Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
(BMC, 2020-03-17)In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
(MDPI, 2022-08-06)Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably ... -
Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
(Springer, 2021-08-24)Background Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the ... -
Squamous cell carcinoma related with dental implants. A clinical cases report.
(Medicina Oral S.L., 2020-01)One third of all cases of head and neck carcinoma (CA) concern the oral mucosa. The use of dental implants (DI) for dental rehabilitation is widely extended. However, a few studies have reported some cases with neoplasic ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
(MDPI, 2020-04-01)Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
3D Biomimetic Porous Titanium (Ti6Al4V ELI) Scaffolds for Large Bone Critical Defect Reconstruction: An Experimental Study in Sheep
(MDPI, 2020-08-11)The main goal in the treatment of large bone defects is to guarantee a rapid loading of the affected limb. In this paper, the authors proposed a new reconstructive technique that proved to be suitable to reach this purpose ... -
Surface nitridation improves bone cell response to melt-derived bioactive silicate/borosilicate glass composite scaffolds
(Elsevier, 2016-01-01)Novel bioactive amorphous glass-glass composite scaffolds (ICIE16/BSG) with interconnected porosity have been developed. Hierarchically interconnected porous glass scaffolds were prepared from a mixture of two melt-derived ... -
Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity.
(British Society for Plant Pathology, 2021-04-01)Chitin is a major structural component of fungal cell walls and acts as a microbe- associated molecular pattern (MAMP) that, on recognition by a plant host, triggers the activation of immune responses. To avoid the activation ... -
The interspecific fungal hybrid Verticillium longisporum displays subgenome-specific gene expression
(American Society for Microbiology, 2021-08)Hybridization is an important evolutionary mechanism that can enable organisms to adapt to environmental challenges. It has previously been shown that the fungal allodiploid species Verticillium longisporum, the causal ... -
Geminivirus Replication Protein impairs SUMO conjugation of PCNA at two acceptor sites.
(ASM Journals, 2018-06-27)Geminiviruses are DNA viruses that replicate in nuclei of infected plant cells using the plant DNA replication machinery, including PCNA (proliferating cellular nuclear antigen), a cofactor that orchestrates genome duplication ... -
Transfer and engineering of immune receptors to improve recognition capacities in crops
(Elsevier Ltd, 2017-08)Immune receptors are pivotal elements of the plant immune system that act as sentinels for microbial invasion. Knowingly or unknowingly, breeding for resistance has largely relied on the transfer of immune receptor recognition ... -
A secreted LysM effector protects fungal hyphae through chitin-dependent homodimer polymerization.
(Public Library of Science, 2020-06-23)Plants trigger immune responses upon recognition of fungal cell wall chitin, followed by the release of various antimicrobials, including chitinase enzymes that hydrolyze chitin. In turn, many fungal pathogens secrete LysM ... -
HrpL regulon of bacterial pathogen of woody host Pseudomonas savastanoi pv. Savastanoi NCPPB 3335
(MDPI, 2021-07)The Pseudomonas savastanoi species comprises a group of phytopathogenic bacteria that cause symptoms of disease in woody hosts. This is mediated by the rapid activation of a pool of virulence factors that suppress host ... -
A lysin motif effector subverts chitin-triggered immunity to facilitate arbuscular mycorrhizal symbiosis
(Wiley, 2020-01)Arbuscular mycorrhizal (AM) fungi greatly improve mineral uptake by host plants in nutrient-depleted soil and can intracellularly colonize root cortex cells in the vast majority of higher plants. However, AM fungi possess ... -
The emerging British Verticillium longisporum population consists of aggressive Brassica pathogens.
(American Phytopathological Society, 2017-08-28)Verticillium longisporum is an economically important fungal pathogen of brassicaceous crops that originated from at least three hybridization events between different Verticillium spp., leading to the hybrid lineages ... -
A collagen-targeted biomimetic RGD peptide to promote osteogenesis
(MARY ANN LIEBERT, INC, 2014-01)Osteogenesis is a complex, multifactorial process in which many different signals interact. The bone morphogenetic proteins (BMPs) are the most potent inducers of osteoblastic differentiation, although very high doses of ... -
41 Cases of Treatment of Cranial Cruciate Ligament Rupture with Porous TTA: Three Years of Follow Up
(MDPI, 2019-02-20)Tibial Tuberosity Advancement (TTA) is a surgical technique based on a linear osteotomy that determines a cranial advancement of the tibial tuberosity in patients suffering from cranial cruciate ligament rupture (CCL). The ... -
In Vitro Induction of Tendon-Specific Markers in Tendon Cells, Adipose- and Bone Marrow-Derived Stem Cells is Dependent on TGF3, BMP-12 and Ascorbic Acid Stimulation
(MDPI, 2019-01-01)Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as useful tools for regenerative medicine approaches in bone, cartilage and tendon-related pathologies. The differentiation of cells towards ...