Listar BCGF - Artículos por título
Mostrando ítems 66-85 de 222
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Early development of anti-natalizumab antibodies in MS patients
(SpringerLink, 2013)The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-β accumulation in AβPP/PS1 Alzheimer's disease mice subiculum.
(IOS Press, 2014)The progressive cognitive decline leading to dementia in Alzheimer’s disease (AD) patients is the consequence of a severe loss of synapses and neurons affecting particular cell subpopulations in selected brain areas, with ... -
Early neuropathology of somatostatin/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer's disease.
(Elsevier, 2006-11)At advanced stages, Alzheimer's disease (AD) is characterized by an extensive neuronal loss. However, the early neurodegenerative deficiencies have not been yet identified. Here we report an extensive, selective and early ... -
Editorial: Risk Factors for Alzheimer's Disease
(Frontiers, 2020-05-07) -
Effect of acute and chronic red wine consumption on lipopolysaccharide concentrations
(Elsevier (The American Journal of Clinical Nutrition), 2013)Background: Chronic red wine (RW) consumption has been associated with decreased cardiovascular disease risk, mainly attributed to an improvement in lipid profile. RW intake is also able to change the composition of gut ... -
Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients
(Elsevier. The Canadian Society of Clinical Chemists., 2010)Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and ... -
Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes.
(British Pharmacological Society, 2016-03-18)Glucagon-like peptide-1 (GLP-1) analogues improve glycaemic control in type 2 diabetic (T2D) patients and cause weight loss in obese subjects by as yet unknown mechanisms. We recently demonstrated that the GLP-1 receptor, ... -
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
(Elsevier, 2013-10-22)Recent studies on tauopathy animal models suggest that the concomitant expression of the endogenous murine tau delays the pathological accumulation of human tau, and interferes with the disease progression. To elucidate ... -
Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients
(American Society for Biochemistry and Molecular Biology, 2012)The low-grade inflammation observed in obesity has been associated with a high-fat diet, though this relation is not fully understood. Bacterial endotoxin, produced by gut microbiota, may be the linking factor. However, ... -
Enhancing arbuscular mycorrhiza symbiosis effectiveness through the involvement of the tomato GRAS transcription factor SCL3/SlGRAS18
(Elsevier, 2024-08)Arbuscular mycorrhizal (AM) fungi improve plant growth, nutrition, fitness and stress tolerance while AM fungi obtain carbohydrates and lipids from the host. This whole process of mutual benefit requires substantial ... -
Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer's disease model.
(Springer Nature, 2020-09-08)In Alzheimer's disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation ... -
ER Bodies Are Induced by Pseudomonas syringae and Negatively Regulate Immunity.
(APS, 2021-09-29)ER bodies are endoplasmic reticulum–derived organelles present in plants belonging to the Brassicales order. In Arabidopsis thaliana, ER bodies are ubiquitous in cotyledons and roots and are present only in certain cell ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
(Elsevier, 2010-07)Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
(Wiley, 2015-03)The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glu-taminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
(Sage, 2009-11-12)Here we demonstrated that extracellular, not intracellular, Aβ and the associated cytotoxic glial neuroinflammatory response are major contributors of early neuronal loss in a PS1xAPP model. A significant loss of principal ... -
FABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels
(PLOS (Public Library of Science), 2012)Background FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile. Objective In patients with a wide BMI range, we analyze FABP4 expression ... -
Functional Analysis of Gene-Silencing Suppressors from Tomato Yellow Leaf Curl Disease Viruses
(APS Publications, 2012-06-01)Tomato yellow leaf curl disease (TYLCD) is caused by a complex of phylogenetically related Begomovirus spp. that produce similar symptoms when they infect tomato plants but have different host ranges. In this work, we ... -
Functional Analysis of V2 Protein of Beet Curly Top Iran Virus
(IOAP-MDPI, 2022-12-02)El virus Geminivirus de la punta rizada de la remolacha de Irán (BCTIV) es uno de los principales agentes causales de la enfermedad de la punta rizada de la remolacha en Irán y la especie tipo del género Becurtovirus ... -
GABAergic deficits in absence of LPA1 receptor, associated anxiety-like and coping behaviors, and amelioration by interneuron precursor transplants into the dorsal hippocampus
(Springer Link, 2021-04-01)Defects in GABAergic function can cause anxiety- and depression-like behaviors among other neuropsychiatric disorders. Therapeutic strategies using the transplantation of GABAergic interneuron progenitors derived from the ... -
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
(Springer, 2019-04-20)Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ...