Listar BCGF - Artículos por título
Mostrando ítems 131-150 de 222
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Mechanisms regulating auxin action during fruit development
(Wiley Online Library, 2013-12-16)Auxin controls many aspects of fruit development, including fruit set and growth, ripening and abscission. However, the mechanisms by which auxin regulates these processes are still poorly understood. While it is generally ... -
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
(American Physiological Society, 2019)Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering ... -
Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain.
(Frontiers Media, 2022-07-28)Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune ... -
Microglia activated by microbial neuraminidase contributes to ependymal cell death.
(Springer Nature, 2021-03-23)The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. ... -
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
(Frontiers, 2018-05)Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ... -
Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors.
(Springer Nature, 2019-12-02)Background: Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administration ... -
Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes
(Frontiers Media, 2019-10-25)Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia have been described: one considered as a resting/surveillant state in which cells have a highly branched morphology, and another ... -
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology
(Elsevier, 2013-09-01)Background Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here, we analyzed the effects of the ... -
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
(Wiley, 2020-02-22)MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation ofsynaptic functions. Among them, recent emerging evidence highlights that micro-RNA-181a (miR-181a) is particularly abundant in hippocampal ... -
miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis
(Oxford University Press, 2021-10-26)Plants encode numerous intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) that recognize pathogen-derived effectors or their activity to activate defenses. miRNAs regulate NLR genes ... -
Molecular and cellular characterization of the age-related neuroinflammatory processes occurring in normal rat hippocampus: potential relation with the loss of somatostatin GABAergic neurons.
(Wiley, 2007-06-29)Increased neuroinflammatory reaction is frequently observed during normal brain aging. However, a direct link between neuroinflammation and neurodegeneration during aging has not yet been clearly shown. Here, we have ... -
Molecular interaction between type 2 diabetes and Alzheimer's disease through cross-seeding of protein misfolding
(Springer Nature, 2017)Numerous epidemiological studies have shown a significantly higher risk for development of Alzheimer's disease (AD) in patients affected by type 2 diabetes (T2D), but the molecular mechanism responsible for this association ... -
Monitoring oocyte-based human pluripotency acquisition using synchrotron-based FTIR microspectroscopy reveals specific biomolecular trajectories
(Elsevier, 2023)The reprogramming of human somatic cells to induced pluripotent cells (iPSCs) has become a milestone and a paradigm shift in the field of regenerative medicine and human disease modeling including drug testing and genome ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
(Biomed Central Ltd, 2023-02-28)Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus
(Oxford University Press, 2004-06)Msx1 is a regulatory gene involved in epithelio-mesenchymal interactions in limb formation and organogenesis. In the embryonic CNS, the Msx1 gene is expressed along the dorsal midline. Msx1 mutant mice have been obtained ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
(Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
(BMC, 2020-03-17)In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Neutralizing antibodies against IFN beta in patients with multiple sclerosis: a comparative study of two cytopathic effect tests (CPE) for their detection
(Elsevier, 2009)The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.
(MDPI, 2024-02-16)Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures ... -
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
(Oxford Academic, 2020)Primary progressive multiple sclerosis is a poorly understood disease entity with no specific prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity biomarkers in multiple sclerosis by ...