Listar BCGF - Artículos por título
Mostrando ítems 155-174 de 222
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Peripheral delivery of neural precursor cells ameliorates parkinson’s disease-associated pathology
(MDPI, 2019)Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by loss of motor control due to a wide loss of dopaminergic neurons along the nigro-striatal pathway. Some of the mechanisms that contribute ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
(Wiley, 2018-03)Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
PipB2 is a substrate of the Salmonella pathogenicity island 1- encoded type III secretion system
(Elvervier, 2012-06-29)Salmonella harbors two type III secretion systems, T3SS1 and T3SS2, encoded on the pathogenicity islands SPI1 and SPI2, respectively. Several effector proteins are secreted through these systems into the eukaryotic host ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
(Frontiers, 2021-11-04)Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
(Elsevier, 2013)Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. ... -
Prognostic Value of Persistent CSF Antibodies at 12 Months in Anti-NMDAR Encephalitis.
(American Academy of Neurology, 2023-05-05)Background and objectives: Anti-NMDA receptor (NMDAR) encephalitis is defined by the presence of antibodies (Abs) targeting the NMDAR in the CSF. This study aimed to determine the prognostic value of persistent CSF NMDAR-Abs ... -
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
(Wolters Kluwer Medknow, 2023-11-08)Memory deficit, which is often associated with aging and many psychiatric, neurological, and neurodegenerative diseases, has been a challenging issue for treatment. Up till now, all potential drug candidates have failed ... -
Protocol: an improved method to quantify activation of systemic acquired resistance (SAR)
(BMC (Springer Nature), 2019-02-14)Background: Plant responses triggered upon detection of an invading pathogen include the generation of a number of mobile signals that travel to distant tissues and determine an increased resistance in distal, uninfected ... -
Protocol: low cost fast and efficient generation of molecular tools for small RNA analysis.
(Springer Nature, 2020-03-20)Small RNAs are sequence-dependent negative regulators of gene expression involved in many relevant plant processes such as development, genome stability, or stress response. Functional characterization of sRNAs in plants ... -
Reactive astrocyte nomenclature, definitions, and future directions.
(Springer Nature, 2021-02-15)Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ... -
Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis
(Elsevier, 2016)Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the ... -
Regulation of plant immunity via small RNA-mediated control of NLR expression
(Oxford University Press, 2023-10-13)Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered ... -
Role of a Gαi2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
(The Company of Biologists, 2007-07-01)Treatment of D2-receptor-expressing cells with specific drugs upregulates the receptor number at the cell surface independently of protein synthesis, leading to the concept of an intracellular receptor pool. However, how ... -
Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory.
(AAAS, 2009-07-03)Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of ... -
Segregation of two glutaminase isoforms in islets of Langerhans.
(Portland Press, 2004-01-31)Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in β-cells is still unresolved. We have found that the endocrine ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
(The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice
(Elsevier, 2023)Combining physical and cognitive training has been suggested to promote further benefits on brain and cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
(Endocrine Society, 2015)Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ... -
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice
(Wiley, 2015-09)Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as ... -
El sistema CRISPR/Cas, un poderoso aliado en la lucha contra los organismos fitopatógenos
(Sociedad Española de Fitopatología, 2018)En la última década se han desarrollado varios sistemas para la edición génica, todos ellos basados en el uso de proteínas de unión a secuencias específicas de DNA, denominadas nucleasas específicas de secuencia (SSN): ...