Listar BCGF - Artículos por título
Mostrando ítems 33-52 de 187
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Basal Sodium-Dependent Vitamin C Transporter 2 polarization in choroid plexus explant cells in normal or scorbutic conditions
Ulloa, Viviana; Saldivia, Natalia; Ferrada, Luciano; Salazar, Katherine; Martínez, Fernando; Silva-Álvarez, Carmen; Magdalena, Rocío; Oviedo, María José; Montecinos, Hernán; Torres-Vergara, Pablo; Cifuentes-Rueda, Manuel
; Nualart, Francisco[et al.] (Springer Nature, 2019-10)
Vitamin C is incorporated into the cerebrospinal fluid (CSF) through choroid plexus cells. While the transfer of vitamin C from the blood to the brain has been studied functionally, the vitamin C transporter, SVCT2, has ... -
Basic fibroblast growth factor enhances the osteogenic differentiation induced by bone morphogenetic protein-6 in vitro and in vivo
Visser, Rick; Arrabal-García, Pilar María; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (ELSEVIER, 2012-04)
Some members of the bone morphogenetic protein subfamily (BMP-2 and -7) are currently used in orthopedic surgery for several applications. Although their use is considered safe at short term, the high doses of growth factors ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.
(Elsevier, 2020-11-23)Background Beyond its structural role in the skeleton, the extracellular matrix (ECM), particularly basement membrane proteins, facilitates communication with intracellular signaling pathways and cell to cell interactions ... -
Brain Glucose-Sensing Mechanism and Energy Homeostasis.
López-Gambero, Antonio Jesús; Martínez, Fernando; Salazar, Katty; Cifuentes-Rueda, Manuel; Nualart, Francisco (Springer Nature, 2019)
The metabolic and energy state of the organism depends largely on the availability of substrates, such as glucose for ATP production, necessary for maintaining physiological functions. Deregulation in glucose levels leads ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2
Pérez-Luna, Ana Isabel; Romero-Rodríguez, Beatriz; Rosas-Díaz, Tábata Victoria; Cerero, Laura; Rodríguez Negrete, Edgar A.; Castillo-Garriga, Araceli; Rodríguez-Bejarano, Eduardo[et al.] (Frontiers, 2020-06-19)
Geminiviruses are single-stranded DNA plant viruses with circular genomes packaged within geminate particles. Among the Geminiviridae family, Begomovirus and Curtovirus comprise the two best characterized genera. Curtovirus ... -
Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species
Villatoro, Antonio J; Alcoholado Cueto, Cristina; Martín Astorga, María del Carmen; Fernández, V.; Cifuentes-Rueda, Manuel; Becerra-Ratia, José[et al.] (Elsevier, 2019-02)
The two main sources of mesenchymal stem cell (MSCs) in the canine species are bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). The secretion of multitude bioactive molecules, included under the concept of secretome ... -
Competitive Index: Mixed Infection-Based Virulence Assays for Genetic Analysis in Pseudomonas syringae-Plant Interactions.
Macho, Alberto P; Rufián, José S.; Ruiz-Albert, Francisco Javier; Beuzón-López, Carmen del Rosario (Humana Press, New York, NY, 2016)
When studying bacterial plant pathogens, the genetic analysis of the contribution of virulence factors to the infection process has traditionally been hindered by their high degree of functional redundancy. In recent years, ... -
Comprehensive Tissue-Specific Transcriptome Analysis Reveals Distinct Regulatory Programs during Early Tomato Fruit Development
(Oxford Academy, 2015-06-22)Fruit formation and early development involve a range of physiological and morphological transformations of the various constituent tissues of the ovary. These developmental changes vary considerably according to tissue ... -
Confocal microscopy reveals in planta dynamic interactions between pathogenic, avirulent and non-pathogenic Pseudomonas syringae strains.
Rufián Plaza, José Sebastián; Macho, Alberto P; Corry, David S; Mansfield, John W; Ruiz-Albert, Francisco Javier; Arnold, Dawn L.; Beuzón-López, Carmen del Rosario[et al.] (Wiley, 2018)
Recent advances in genomics and single-cell analysis have demonstrated the extraordinary complexity reached by microbial populations within their hosts. Communities range from complex multispecies groups to homogeneous ... -
Correction to: Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.
Boza-Serrano, Antonio; Ruiz, Rocío; Sánchez-Varo, Raquel María; García-Revilla, Juan; Yang, Yiyi; Jiménez-Ferrer, Itzia; Paulus, Agnes; Wennström, Malin; Vilalta, Anna; Allendorf, David; Dávila-Cansino, José Carlos; Stegmayr, John; Jiménez, Sebastián; Roca-Ceballos, Maria A.; Navarro-Garrido, Victoria; Swanberg, Maria; Hsieh, Christine L; Real-Navarrete, Luis Miguel; Englund, Elisabeth; Linse, Sara; Leffler, Hakon; Nilsson, Ulf J.; Brown, Guy C; Gutiérrez-Pérez, Antonia; Vitorica, Javier; Venero, José Luis; Deierborg, Thomas[et al.] (Springer, 2023-02-15)
Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are ... -
Cross-reactivity of antibodies against interferon beta in multiple sclerosis patients and interference of the JAK-STAT signaling pathway
Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesus; Urbaneja, Patricia; Rodríguez-Bada, José Luis; Ortega-Pinazo, Jesús; Serrano-Castro, Pedro Jesús; Fernández-Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Nature, 2017)
Interferon beta (IFNβ) therapy has immunogenic properties and induces the development of neutralizing antibodies (NAbs). From the extensive literature focused in the development of NAbs in multiple sclerosis (MS) patients, ... -
Decreased soluble IFN-β receptor (sIFNAR2) in multiple sclerosis patients: A potential serum diagnostic biomarker
Órpez-Zafra, Teresa; Pavía-Molina, José; Hurtado-Guerrero, Isaac; Pinto-Medel, Maria Jesús; Rodríguez-Bada, José Luis; Urbaneja, Patricia; Suardíaz García, Margarita; Villar, Luisa M; Comabella, Manuel; Montalban, Xavier; Alvarez-Cermeño, Jose C; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (SAGE Journals, 2017)
Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in ... -
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres, Manuel; Jiménez, Sebastián; Sánchez-Varo, Raquel María; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Carmona, Irene; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2012-11-22)
Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in patients and transgenic models. These dystrophies could reflect the disruption of axonal transport ... -
Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice
Forman, Katherine; Martínez, Fernando; Cifuentes-Rueda, Manuel; Fernández, Marcos; Bertinar, Romina; Torres, Pablo; Salazar, Katherine; Godoy, Alejandro; Nualart, Francisco[et al.] (Wiley, 2020-12)
Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. ... -
Dendritic scaffold onto titanium implants. A versatile strategy increasing biocompatibility.
Molina, Noemí; González, Ana; Monopoli, Donato; Mentado, Belinda; Becerra-Ratia, José; Santos-Ruiz, Leonor; Vida-Pol, Yolanda; Pérez-Inestrosa, Ezequiel[et al.] (MDPI, 2020-04-01)
Osseointegration of metal prosthetic implants is a yet unresolved clinical need that depends on the interplay between the implant surface and bone cells. The lack of a relationship between bone cells and metal has traditionally ... -
Development and validation of an ELISA for quantification of soluble IFN-β receptor: assessment in multiple sclerosis
Órpez-Zafra, Teresa; Pavía-Molina, José; Pinto-Medel, Maria Jesús; Hurtado-Guerrero, Isaac; Rodríguez-Bada, José Luis; Martín-Montañez, Elisa; Fernández Fernández, Óscar; Leyva-Fernández, Laura; Oliver-Martos, Begoña[et al.] (Taylor & Francis, 2015)
Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, ... -
Diagnosis of immediate reactions to amoxicillin: Comparison of basophil activation markers CD63 and CD203c in a prospective study
Céspedes Lagos, José Antonio; Fernández-Santamaría, Rubén; Ariza Veguillas, Adriana; Bogas Herrera, Gádor; Doña, Inmaculada; Rondón, Carmen; Salas, María; Labella, Marina; Frecha, Cecilia; Mayorga Mayorga, Cristobalina; Torres-Jaén, María Josefa; Fernández-Duarte, Tahía Diana[et al.] (Wiley, 2022-12-07)
Amoxicillin (AX) combined or not with clavulanic acid (CLV) is frequently involved in IgE-mediated reactions. Drug provocation test (DPT) is considered as the gold standard for diagnosis, although contraindicated in high-risk ... -
Dietary administration of D-chiro-inositol attenuates sex-specific metabolic imbalances in the 5xFAD mouse model of Alzheimer’s disease
López-Gambero, Antonio J.; Pacheco-Sánchez, Beatriz; Rosell-del-Valle, Cristina; Medina-Vera, Dina; Navarro, Juan Antonio; Fernández-Arjona, María del Mar; De Ceglia, Marialuisa; Sanjuán-Solís, Jesús Carlos; Simon, Vincent; Cota, Daniela; Rivera, Patricia; Rodriguez-de-Fonseca, Fernando; Suárez-Pérez, Juan[et al.] (Elsevier, 2022-06)
Increasing evidence shows that hypothalamic dysfunction, insulin resistance, and weight loss precede and progress along with the cognitive decline in sporadic Alzheimer’s Disease (AD) with sex differences. This study aimed ...