Listar BCGF - Artículos por título
Mostrando ítems 89-108 de 187
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HrpL regulon of bacterial pathogen of woody host Pseudomonas savastanoi pv. Savastanoi NCPPB 3335
Moreno-Pérez, Alba; Ramos-Rodríguez, Cayo Juan
; Rodríguez-Moreno, Luis Gabriel (MDPI, 2021-07)
The Pseudomonas savastanoi species comprises a group of phytopathogenic bacteria that cause symptoms of disease in woody hosts. This is mediated by the rapid activation of a pool of virulence factors that suppress host ... -
Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease.
García-León, Juan Antonio; Cáceres Palomo, Laura; Sánchez-Mejías, Elisabeth; Mejías-Ortega, Marina; Núñez-Díaz, Cristina; Fernández-Valenzuela, Juan José; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (MDPI, 2020-09-18)
Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still not fully understood, since different ... -
Hyperglycemia increases SCO-spondin and Wnt5a secretion into the cerebrospinal fluid to regulate ependymal cell beating and glucose sensing
Nualart, Francisco; Cifuentes-Rueda, Manuel; Ramírez, Eder; Martínez, Fernando; Barahona, M José; Ferrada, Luciano; Saldivia, N; Borgonzone, Ernesto R; Thorens, B; Salazar, Katterine[et al.] (Public Library of Science, 2023-09)
Hyperglycemia increases glucose concentrations in the cerebrospinal fluid (CSF), activating glucose-sensing mechanisms and feeding behavior in the hypothalamus. Here, we discuss how hyperglycemia temporarily modifies ... -
Hypoxia compromises the mitochondrial metabolism of Alzheimer’s disease microglia via HIF1
March-Diaz, Rosana; Lara-Ureña, Nieves; Romero-Molina, Carmen; Heras-Garvin, Antonio; Ortega-de San Luis, Clara; Alvarez-Vergara, Maria I; Sanchez-Garcia, Manuel A; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Rosales-Nieves, Alicia E; Forja, Cristina; Navarro, Victoria; Gomez-Arboledas, Ángela; Sánchez-Mico, María Virtudes; Viehweger, Adrian; Gerpe, Almudena; Hodson, Emma J; Vizuete, Marisa; Bishop, Tammie; Serrano-Pozo, Alberto; Lopez-Barneo, Jose; Berra, Edurne; Gutiérrez-Pérez, Antonia; Vitorica, Javier; Pascual, Alberto[et al.] (Nature Research, 2021-04)
Genetic Alzheimer’s disease (AD) risk factors associate with reduced defensive amyloid β plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to microglial dysfunction is unknown. In AD ... -
Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.
Alcina, Antonio; Fedetz, María; Fernández, Óscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva-Fernández, Laura; García-León, Juan Antonio; Abad-Grau, María del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María Jesús; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla[et al.] (BMJ Journals, 2013-01)
Background and aim: Several studies have highlighted the association of the 12q13.3-12q14.1 region with coeliac disease, type 1 diabetes, rheumatoid arthritis and multiple sclerosis (MS); however, the causal variants ... -
Identification of Host Genes Involved in Geminivirus Infection Using a Reverse Genetics Approach
Lozano Durán, Rosa; Rosas-Díaz, Tábata Victoria; Pérez-Luna, Ana Isabel; Rodríguez-Bejarano, Eduardo (PlosONE, 2011-07-26)
Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia ... -
IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response.
Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Fedetz, María; Blanco, Eva; Fernández, Victoria E.; Oliver-Martos, Begoña; León, Antonio; Pinto-Medel, María Jesús; Mayorga Mayorga, Cristobalina; Guerrero, Miguel; Luque, Gloria; Alcina, Antonio; Matesanz, Fuencisla[et al.] (Elsevier, 2005-04-22)
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNβ treatment response in a group of 147 patients and ... -
IIIG9 inhibition in adult ependymal cells changes adherens junctions structure and induces cellular detachment.
Baeza, Víctor; Cifuentes-Rueda, Manuel; Martínez, Fernando; Ramírez, Eder; Nualart, Francisco; Ferrada, Luciano; Oviedo, María José; De Lima, Isabelle; Troncoso, Ninoschka; Saldivia, Natalia; Salazar, Katty[et al.] (Springer Nature, 2021)
Ependymal cells have multiple apical cilia that line the ventricular surfaces and the central canal of spinal cord. In cancer, the loss of ependymal cell polarity promotes the formation of different types of tumors, such ... -
Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.
(Wiley, 2018-08-17)Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, ... -
In Vitro Induction of Tendon-Specific Markers in Tendon Cells, Adipose- and Bone Marrow-Derived Stem Cells is Dependent on TGF3, BMP-12 and Ascorbic Acid Stimulation
Perucca Orfei, Carlotta; Viganò, Marco; Pearson, John R.; Colombini, A.; De Luca, P.; Ragni, E.; Santos-Ruiz, Leonor; De Girolamo, Laura[et al.] (MDPI, 2019-01-01)
Mesenchymal Stem Cells (MSCs) and tissue-specific progenitors have been proposed as useful tools for regenerative medicine approaches in bone, cartilage and tendon-related pathologies. The differentiation of cells towards ... -
In vitro stimulation of MC3T3-E1cells and sustained drug delivery by a hierarchical nanostructured SiO2-CaO-P2O5 scaffold
Ramiro-Gutiérrez, María Lourdes; Santos-Ruiz, Leonor; Borrego-González, Sara; Becerra-Ratia, José; Díaz-Cuenca, Aránzazu (Elsevier, 2016-07-15)
A hierarchical scaffold, SP1_h_HA, consisting of a biomimetic nano-hydroxyapatite surface coating growth onto a reticulated structure having a nano-organized porous texture was fabricated and functionally studied in vitro ... -
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology.
Trujillo-Estrada, Laura Isabel; Jiménez, Sebastián; De Castro, Vanessa; Torres, Manuel; Baglietto-Vargas, David; Moreno-González, Inés; Navarro, Victoria; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2013)
Background: Alzheimer's disease (AD) is characterized by the abnormal accumulation of extracellular beta-amyloid (Abeta) plaques, intracellular hyperphosphorylated tau, progressive synaptic alterations, axonal dystrophies, ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers
Queipo-Ortuño, María Isabel; Boto-Ordóñez, María; Murri Pierri, Mora; Gómez-Zumaquero, Juan Miguel; Clemente-Postigo, María Mercedes; Estruch, Ramón; Cardona-Díaz, Fernando; Andrés-Lacueva, Cristina; Tinahones-Madueño, Francisco José[et al.] (Elsevier (American Society for Nutrition), 2012)
Background: Few studies have investigated the effect of dietary polyphenols on the complex human gut microbiota, and they focused mainly on single polyphenol molecules and select bacterial populations. Objective: The ... -
Integrated single-base resolution maps of transcriptome, sRNAome and methylome of Tomato yellow leaf curl virus (TYLCV) in tomato
Piedra-Aguilera, Álvaro; Jiao, Chen; Pérez-Luna, Ana Isabel; Villanueva, Francisco; Dabad, Marc; Esteve-Codina, Anna; Diaz-Pendón, Juan Antonio; Fei, Zhangjun; Rodríguez-Bejarano, Eduardo; Castillo-Garriga, Araceli[et al.] (Springer Nature, 2019-02-27)
Geminiviruses are plant ssDNA viruses that replicate through dsDNA intermediates and form minichromosomes which carry the same epigenetic marks as the host chromatin. During the infection, geminiviruses are targets of ... -
Interferon receptor expression in multiple sclerosis patients
Oliver-Martos, Begoña; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; León, Antonio; Luque, Gloria; C Lopez, Juan; Tamayo, Jose A; Pinto-Medel, Maria Jesús; De Ramón, Enrique; Blanco, Eva; Alonso, Ana; Fernández Fernández, Óscar[et al.] (Elsevier, 2006)
To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 ... -
Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus
Forner, Stefania; Martini, Alessandra; Prieto, Gilberto Aleph; Dang, Cindy; Rodriguez-Ortiz, Carlos; Reyes Ruiz, Jorge Mauricio; Trujillo-Estrada, Laura Isabel; da Cunha, Celia; Andrews, Elizabeth; Phan, Jimmy; Ha, Jordan; Chang, Allissa; Levites, Yona; Cruz, Pedro; Ager, Rahasson; Medeiros, Rodrigo; Kitazawa, Masashi; Glabe, Charles; Cotman, Carl; Golde, Todd; Baglietto-Vargas, David; LaFerla, Frank M[et al.] (Springer Nature, 2019-11)
Alzheimer's disease (AD), the most common age-related neurodegenerative disorder, is currently conceptualized as a disease of synaptic failure. Synaptic impairments are robust within the AD brain and better correlate with ... -
Is IIIG9 a New Protein with Exclusive Ciliary Function? Analysis of Its Potential Role in Cancer and Other Pathologies
Oviedo, MJ; Ramírez, E; Cifuentes-Rueda, Manuel; Farkas, Carlos; Mella, Andy; Bertinat, Romina; Gajardo, Roberto; Ferrada, Luciano; Jara, Nery; De lima, Isabelle; Martínez, Fernando; Nualart, Francisco; Salazar, Katerine[et al.] (MDPI, 2022-10)
The identification of new proteins that regulate the function of one of the main cellular phosphatases, protein phosphatase 1 (PP1), is essential to find possible pharmacological targets to alter phosphatase function in ... -
Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients.
García-León, Juan Antonio; Pinto-Medel, María-Jesús; García-Trujillo, Lucía; López-Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2011-09)
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response
García-León, Juan Antonio; López-Gómez, Carlos; Orpez-Zafra, Teresa; Reyes-Garrido, Virginia; Marín Bañasco, Carmen; Oliver-Martos, Begoña; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Springer Link, 2014)
Background: Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and ...