Listar BCGF - Artículos por título
Mostrando ítems 107-126 de 187
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Killer cell immunoglobulin-like receptor genes in Spanish multiple sclerosis patients.
García-León, Juan Antonio
; Pinto-Medel, María-Jesús; García-Trujillo, Lucía; López-Gómez, Carlos; Oliver-Martos, Begoña; Prat-Arrojo, Isidro; Marín-Bañasco, Carmen; Suardíaz-García, Margarita; Maldonado-Sánchez, Rafael; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Elsevier, 2011-09)
Killer cell immunoglobulin-like receptors (KIRs) are regulators of cytolytic activity of natural killer and certain T cells through interactions with human leukocyte antigen (HLA) class I ligands. KIRs have been shown to ... -
Killer-cell immunoglobulin-like receptor expression on lymphocyte subsets in multiple sclerosis patients treated with interferon-β: evaluation as biomarkers for clinical response
García-León, Juan Antonio; López-Gómez, Carlos; Orpez-Zafra, Teresa; Reyes-Garrido, Virginia; Marín Bañasco, Carmen; Oliver-Martos, Begoña; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (Springer Link, 2014)
Background: Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and ... -
Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months.
Oliver-Martos, Begoña; Fernández, Óscar; Orpez, Teresa; Alvarenga, Marco Papais; Pinto-Medel, María Jesús; Guerrero, Miguel; León, Antonio; López-Madrona, José Carlos; Maldonado-Sánchez, Rafael; García-León, Juan Antonio; Luque, Gloria; Fernández, Victoria; Leyva-Fernández, Laura[et al.] (SAGE, 2011-03)
Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ... -
Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery
Clemente-Postigo, María Mercedes; Roca-Rodríguez, María del Mar; Camargo, Antonio; Ocaña-Wilhelmi, Luis Tomás; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (Elsevier (American Society for Metabolic and Bariatric Surgery), 2015)
Background: Bariatric surgery usually results in metabolic improvements within a few days from intervention, but the underlying mechanism is not completely understood and may vary depending on the bariatric procedure. ... -
Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain
López-Aranda, Manuel Francisco; Acevedo, Maria J.; Carballo, Francisco J.; Gutiérrez-Pérez, Antonia; Khan, Zafaruddin (WILEY, 2006-06)
Regulator of G-protein signalling (RGS)12 and -14 proteins possess the RGS domain, Ras-binding domains and the GoLoco motif. Emerging evidence suggests that these proteins are involved in several cellular functions in ... -
Long-term priming of hypothalamic microglia is associated with energy balance disturbances under diet-induced obesity
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Wiley, 2022-05-22)
Exposure of microglia to an inflammatory environment may lead to their priming and exacerbated response to future inflammatory stimuli. Here we aimed to explore hypothalamic microglia priming and its consequences on energy ... -
Long-term reprogramming of primed microglia after moderate inhibition of CSF1R signaling.
León-Rodríguez, Ana; Mateos-Grondona, Jesús; Marín Wong, Sonia; López-Aranda, Manuel Francisco; López-Ávalos, María Dolores (Wiley, 2024)
In acute neuroinflammation, microglia activate transiently, and return to a resting state later on. However, they may retain immune memory of such event, namely priming. Primed microglia are more sensitive to new stimuli ... -
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor
(PLOS One, 2011-12)Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA1–6, showing ... -
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
Clemente-Postigo, María Mercedes; Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Ramos-Molina, Bruno; Giráldez-Pérez, Rosa María; Lhamyani, Said; Alcaide Torres, Juan; Pérez-Martínez, Pablo; El Bekay Rizky, Rajaa; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Physiological Society, 2019)
Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering ... -
Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Frontiers Media, 2022-07-28)
Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune ... -
Microglia activated by microbial neuraminidase contributes to ependymal cell death.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; López-Ávalos, María Dolores; Mateos-Grondona, Jesús (Springer Nature, 2021-03-23)
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. ... -
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Navarro-Garrido, Victoria; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Muñoz-Castro, Clara; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Frontiers, 2018-05)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ... -
Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors.
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Springer Nature, 2019-12-02)
Background: Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administration ... -
Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Frontiers Media, 2019-10-25)
Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia have been described: one considered as a resting/surveillant state in which cells have a highly branched morphology, and another ... -
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology
(Elsevier, 2013-09-01)Background Increased circulating glucocorticoids are features of both aging and Alzheimer’s disease (AD), and increased glucocorticoids accelerate the accumulation of AD pathologies. Here, we analyzed the effects of the ... -
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz, Carlos; Prieto, Gilberto Aleph; Martini, Alessandra; Forner, Stefania; Trujillo-Estrada, Laura Isabel; LaFerla, Frank M.; Baglietto-Vargas, David; Cotman, Carl; Kitazawa, Masashi[et al.] (Wiley, 2020-02-22)
MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation ofsynaptic functions. Among them, recent emerging evidence highlights that micro-RNA-181a (miR-181a) is particularly abundant in hippocampal ... -
miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis
López-Márquez, Diego; Del Espino Pérez, Ángel; López-Pagán, Nieves; Rodrígez-Negrete, Edgar A.; Rubio-Somoza, Ignacio; Ruiz-Albert, Francisco Javier; Rodríguez-Bejarano, Eduardo; Beuzón-López, Carmen del Rosario[et al.] (Oxford University Press, 2021-10-26)
Plants encode numerous intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) that recognize pathogen-derived effectors or their activity to activate defenses. miRNAs regulate NLR genes ... -
Monitoring oocyte-based human pluripotency acquisition using synchrotron-based FTIR microspectroscopy reveals specific biomolecular trajectories
(Elsevier, 2023)The reprogramming of human somatic cells to induced pluripotent cells (iPSCs) has become a milestone and a paradigm shift in the field of regenerative medicine and human disease modeling including drug testing and genome ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
(Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ...