Listar BCGF - Artículos por título
Mostrando ítems 114-133 de 183
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Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity
Clemente-Postigo, María Mercedes
; Oliva Olivera, Wilfredo; Coín-Aragüez, Leticia I.; Ramos-Molina, Bruno; Giráldez-Pérez, Rosa María; Lhamyani, Said; Alcaide Torres, Juan; Pérez-Martínez, Pablo; El Bekay Rizky, Rajaa; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José[et al.] (American Physiological Society, 2019)
Impaired adipose tissue (AT) lipid handling and inflammation is associated with obesity-related metabolic diseases. Circulating lipopolysaccharides (LPSs) from gut microbiota (metabolic endotoxemia), proposed as a triggering ... -
Microbial neuraminidase induces TLR4-dependent long-term immune priming in the brain.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; Mateos-Grondona, Jesús; López-Ávalos, María Dolores (Frontiers Media, 2022-07-28)
Innate immune memory explains the plasticity of immune responses after repeated immune stimulation, leading to either enhanced or suppressed immune responses. This process has been extensively reported in peripheral immune ... -
Microglia activated by microbial neuraminidase contributes to ependymal cell death.
Fernández-Arjona, María del Mar; León-Rodríguez, Ana; López-Ávalos, María Dolores; Mateos-Grondona, Jesús (Springer Nature, 2021-03-23)
The administration of microbial neuraminidase into the brain ventricular cavities of rodents represents a model of acute aseptic neuroinflammation. Ependymal cell death and hydrocephalus are unique features of this model. ... -
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Navarro-Garrido, Victoria; Sánchez-Mejías, Elisabeth; Jiménez, Sebastián; Muñoz-Castro, Clara; Sánchez-Varo, Raquel María; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Frontiers, 2018-05)
Microglial activation has been considered a crucial player in the pathological process of multiple human neurodegenerative diseases. In some of these pathologies, such as Amyotrophic Lateral Sclerosis or Multiple Sclerosis, ... -
Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors.
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Springer Nature, 2019-12-02)
Background: Neuraminidase (NA) is a sialidase present, among various locations, in the envelope/membrane of some bacteria/viruses (e.g., influenza virus), and is involved in infectiveness and/or dispersion. The administration ... -
Microglial Morphometric Parameters Correlate With the Expression Level of IL-1β, and Allow Identifying Different Activated Morphotypes
Fernández-Arjona, María del Mar; Mateos-Grondona, Jesús; Fernández-Llebrez, Pedro; López-Ávalos, María Dolores (Frontiers Media, 2019-10-25)
Microglia are the resident macrophages in the brain. Traditionally, two forms of microglia have been described: one considered as a resting/surveillant state in which cells have a highly branched morphology, and another ... -
miR-181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer's disease.
Rodriguez-Ortiz, Carlos; Prieto, Gilberto Aleph; Martini, Alessandra; Forner, Stefania; Trujillo-Estrada, Laura Isabel; LaFerla, Frank M.; Baglietto-Vargas, David; Cotman, Carl; Kitazawa, Masashi[et al.] (Wiley, 2020-02-22)
MicroRNAs play a pivotal role in rapid, dynamic, and spatiotemporal modulation ofsynaptic functions. Among them, recent emerging evidence highlights that micro-RNA-181a (miR-181a) is particularly abundant in hippocampal ... -
miR825-5p targets the TIR-NBS-LRR gene MIST1 and down-regulates basal immunity against Pseudomonas syringae in Arabidopsis
López-Márquez, Diego; Del Espino Pérez, Ángel; López-Pagán, Nieves; Rodrígez-Negrete, Edgar A.; Rubio-Somoza, Ignacio; Ruiz-Albert, Francisco Javier; Rodríguez-Bejarano, Eduardo; Beuzón-López, Carmen del Rosario[et al.] (Oxford University Press, 2021-10-26)
Plants encode numerous intracellular receptors known as nucleotide-binding leucine-rich repeat receptors (NLRs) that recognize pathogen-derived effectors or their activity to activate defenses. miRNAs regulate NLR genes ... -
Monitoring oocyte-based human pluripotency acquisition using synchrotron-based FTIR microspectroscopy reveals specific biomolecular trajectories
(Elsevier, 2023)The reprogramming of human somatic cells to induced pluripotent cells (iPSCs) has become a milestone and a paradigm shift in the field of regenerative medicine and human disease modeling including drug testing and genome ... -
Monocyte-derived cells invade brain parenchyma and amyloid plaques in human Alzheimer’s disease hippocampus.
Muñoz-Castro, Clara; Mejías-Ortega, Marina; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Trujillo-Estrada, Laura Isabel; Jimenez, Sebastian; García-León, Juan Antonio; Fernández-Valenzuela, Juan José; Sanchez-Mico, María Virtudes; Romero-Molina, Carmen; Moreno-González, Inés; Baglietto-Vargas, David; Marisa, Vizuete; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Biomed Central Ltd, 2023-02-28)
Microglia play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer’s disease (AD). However, the contribution of nonparenchymal or brain‑infiltrated myeloid cells to disease progression ... -
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
(Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
García-Bonilla, María; Ojeda-Pérez, Betsaida; García-Martín, María Luisa; Muñoz-Hernández, María del Carmen; Vitorica, Javier; Jiménez, Sebastián; Cifuentes-Rueda, Manuel; Santos-Ruiz, Leonor; Shumilov, Kirill; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Páez-González, Patricia[et al.] (BMC, 2020-03-17)
In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Neutralizing antibodies against IFN beta in patients with multiple sclerosis: a comparative study of two cytopathic effect tests (CPE) for their detection
Oliver-Martos, Begoña; Orpez, Teresa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; López-Gómez, Carlos; Marín, Carmen; Luque, Gloria; Fernández Fernández, Óscar[et al.] (Elsevier, 2009)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.
Alberca-Del Arco, Fernardo; Prieto-Cuadra, Daniel; Santos-Perez de la Blanca, Rocio; Sáez-Barranquero, Felipe; Matas-Rico, Elisa; Herrera-Imbroda, Bernardo[et al.] (MDPI, 2024-02-16)
Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures ... -
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
Malhotra, Sunny; Costa, Carme; Eixarch, Herena; Keller, Christian W; Lukas Amman, Lukas; Martínez-Banaclocha, Helios; Midaglia, Luciana; Sarró, Eduard; Isabel Machín-Díaz, Isabel; M Villar, Luisa; Triviño, Juan Carlos; Oliver-Martos, Begoña; Navarro Parladé, Laura; Calvo-Barreiro, Laura; Matesanz, Fuencisla; Vandenbroeck, Koen; Urcelay, Elena; María-Luisa Martínez-Ginés, María-Luisa; Tejeda-Velarde, Amalia; Fissolo, Nicolás; Castilló, Joaquín; Sanchez, Alex; Robertson, Avril A B; Clemente, Diego; Prinz, Marco; Pelegrin, Pablo; Lünemann, Jan D; Espejo, Carmen; Montalban, Xavier; Comabella, Manuel[et al.] (Oxford Academic, 2020)
Primary progressive multiple sclerosis is a poorly understood disease entity with no specific prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity biomarkers in multiple sclerosis by ... -
NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis
Malhotra, Sunny; Rio, Jordi; Urcelay, Elena; Nurtdinov, Ramil; F Bustamante, Marta; Fernández Fernández, Óscar; Oliver-Martos, Begoña; Zettl, Uwe; Brassat, David; Killestein, Joep; Lechner-Scott, Jeannette; Drulovic, Jelena; Chan, Andrew; Martinelli-Boneschi, Filippo; García-Merino, Antonio; Montalban, Xavier; Comabella, Manuel[et al.] (2015)
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Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
Kazantseva, Liliya; Becerra-Ratia, José; Santos-Ruiz, Leonor (Springer, 2021-08-24)
Background Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the ... -
Osteogenic molecules for clinical applications: Improving the BMP-collagen system
Arrabal-García, Pilar María; Visser, Rick; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (Sociedad de Biología de Chile, 2013)
Among the osteogenic growth factors used for bone tissue engineering, bone morphogenetic proteins (BMPs) are the most extensively studied for use in orthopaedic surgery. BMP-2 and BMP-7 have been widely investigated for ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ...