Listar BCGF - Artículos por título
Mostrando ítems 126-145 de 187
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Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells
(Elife, 2017-08-29)The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion. uPAR mediates degradation of the extracellular matrix ... -
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells.
García-Bonilla, María; Ojeda-Pérez, Betsaida; García-Martín, María Luisa; Muñoz-Hernández, María del Carmen; Vitorica, Javier; Jiménez, Sebastián; Cifuentes-Rueda, Manuel
; Santos-Ruiz, Leonor; Shumilov, Kirill; Claros-Gil, Silvia; Gutiérrez-Pérez, Antonia; Páez-González, Patricia[et al.] (BMC, 2020-03-17)
In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial ... -
Neutralizing antibodies against IFN beta in patients with multiple sclerosis: a comparative study of two cytopathic effect tests (CPE) for their detection
Oliver-Martos, Begoña; Orpez, Teresa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; López-Gómez, Carlos; Marín, Carmen; Luque, Gloria; Fernández Fernández, Óscar[et al.] (Elsevier, 2009)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
New Perspectives on the Role of Liquid Biopsy in Bladder Cancer: Applicability to Precision Medicine.
Alberca-Del Arco, Fernardo; Prieto-Cuadra, Daniel; Santos-Perez de la Blanca, Rocio; Sáez-Barranquero, Felipe; Matas-Rico, Elisa; Herrera-Imbroda, Bernardo[et al.] (MDPI, 2024-02-16)
Bladder cancer (BC) is one of the most common tumors in the world. Cystoscopy and tissue biopsy are the standard methods in screening and early diagnosis of suspicious bladder lesions. However, they are invasive procedures ... -
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
Malhotra, Sunny; Costa, Carme; Eixarch, Herena; Keller, Christian W; Lukas Amman, Lukas; Martínez-Banaclocha, Helios; Midaglia, Luciana; Sarró, Eduard; Isabel Machín-Díaz, Isabel; M Villar, Luisa; Triviño, Juan Carlos; Oliver-Martos, Begoña; Navarro Parladé, Laura; Calvo-Barreiro, Laura; Matesanz, Fuencisla; Vandenbroeck, Koen; Urcelay, Elena; María-Luisa Martínez-Ginés, María-Luisa; Tejeda-Velarde, Amalia; Fissolo, Nicolás; Castilló, Joaquín; Sanchez, Alex; Robertson, Avril A B; Clemente, Diego; Prinz, Marco; Pelegrin, Pablo; Lünemann, Jan D; Espejo, Carmen; Montalban, Xavier; Comabella, Manuel[et al.] (Oxford Academic, 2020)
Primary progressive multiple sclerosis is a poorly understood disease entity with no specific prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity biomarkers in multiple sclerosis by ... -
NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis
Malhotra, Sunny; Rio, Jordi; Urcelay, Elena; Nurtdinov, Ramil; F Bustamante, Marta; Fernández Fernández, Óscar; Oliver-Martos, Begoña; Zettl, Uwe; Brassat, David; Killestein, Joep; Lechner-Scott, Jeannette; Drulovic, Jelena; Chan, Andrew; Martinelli-Boneschi, Filippo; García-Merino, Antonio; Montalban, Xavier; Comabella, Manuel[et al.] (2015)
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Oridonin enhances antitumor effects of doxorubicin in human osteosarcoma cells
Kazantseva, Liliya; Becerra-Ratia, José; Santos-Ruiz, Leonor (Springer, 2021-08-24)
Background Doxorubicin is the chemotherapeutic drug of choice in osteosarcoma treatment, but its cumulative administration causes dilated cardiomyopathy. Combination therapy represents a potential strategy to reduce the ... -
Osteogenic molecules for clinical applications: Improving the BMP-collagen system
Arrabal-García, Pilar María; Visser, Rick; Santos-Ruiz, Leonor; Becerra-Ratia, José; Cifuentes-Rueda, Manuel (Sociedad de Biología de Chile, 2013)
Among the osteogenic growth factors used for bone tissue engineering, bone morphogenetic proteins (BMPs) are the most extensively studied for use in orthopaedic surgery. BMP-2 and BMP-7 have been widely investigated for ... -
Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
Tinahones-Madueño, Francisco José; Queipo Ortuño, Maria Isabel; Clemente-Postigo, María Mercedes; Fernandez-García, Diego; Mingrone, Geltrude; Cardona-Díaz, Fernando[et al.] (Elsevier, 2013)
Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. ... -
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
Navarro-Lobato, Irene; Masmudi-Martín, Mariam; López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Delgado, Gloria; Granados-Durán, Pablo; Gaona-Romero, Celia; Carretero-Rey, Marta; Posadas, Sinforiano; Quirós-Ortega, María Elena; Khan, Zafaruddin[et al.] (Wolters Kluwer Medknow, 2023-11-08)
Memory deficit, which is often associated with aging and many psychiatric, neurological, and neurodegenerative diseases, has been a challenging issue for treatment. Up till now, all potential drug candidates have failed ... -
Protocol: an improved method to quantify activation of systemic acquired resistance (SAR)
Rufián Plaza, José Sebastián; Rueda-Blanco, Javier; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (BMC (Springer Nature), 2019-02-14)
Background: Plant responses triggered upon detection of an invading pathogen include the generation of a number of mobile signals that travel to distant tissues and determine an increased resistance in distal, uninfected ... -
Protocol: low cost fast and efficient generation of molecular tools for small RNA analysis.
López-Márquez, Diego; Del-Espino, Ángel; Rodríguez-Bejarano, Eduardo; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (Springer Nature, 2020-03-20)
Small RNAs are sequence-dependent negative regulators of gene expression involved in many relevant plant processes such as development, genome stability, or stress response. Functional characterization of sRNAs in plants ... -
Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, Carole; Galea, Elena; Lakatos, András; O`Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhäuser, Christian; Volterra, Andrea; Carmignoto, Giorgo; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei-Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Diaz-Castillo, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Götz, Magdalena; Gutiérrez-Pérez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Lino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; Lee, Justin C.; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Mural, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stéphane H.R.; Oliveira, Joao F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Perez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina-Beate; Wood, Levi B.; Wu, Jiagin; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael; Verkhratsky, Alexei[et al.] (Springer Nature, 2021-02-15)
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ... -
Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis
Suardíaz García, Margarita; Clemente, Diego; Marín Bañasco, Carmen; Órpez, Teresa; Hurtado-Guerrero, Isaac; Pavía-Molina, José; Pinto-Medel, Maria Jesús; De Castro, Fernando; Leyva-Fernández, Laura; Fernández Fernández, Óscar; Oliver-Martos, Begoña[et al.] (Elsevier, 2016)
Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the ... -
Regulation of plant immunity via small RNA-mediated control of NLR expression
López-Márquez, Diego; Del Espino Pérez, Ángel; Ruiz-Albert, Francisco Javier; Rodríguez-Bejarano, Eduardo; Brodersen, Peter; Beuzón-López, Carmen del Rosario[et al.] (Oxford University Press, 2023-10-13)
Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered ... -
Role of a Gαi2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
López-Aranda, Manuel Francisco; Acevedo, Maria J.; Gutiérrez-Pérez, Antonia; Koulen, Peter; Khan, Zafaruddin (The Company of Biologists, 2007-07-01)
Treatment of D2-receptor-expressing cells with specific drugs upregulates the receptor number at the cell surface independently of protein synthesis, leading to the concept of an intracellular receptor pool. However, how ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
(The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Pérez-Berlanga, José Manuel; Mullor-Vigo, Rosa; Zambrana-Infantes, Emma; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (Elsevier, 2023)
Combining physical and cognitive training has been suggested to promote further benefits on brain and cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated ...