Listar BCGF - Artículos por título
Mostrando ítems 134-153 de 187
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Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease
Gómez-Arboledas, Ángela; Davila, Jose Carlos; Sánchez-Mejías, Elisabeth
; Navarro, Victoria; Núñez-Díaz, Cristina; Sánchez-Varo, Raquel María; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Fernández-Valenzuela, Juan José; Vizuete, Marisa; Comella, Joan X.; Galea, Elena; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Wiley, 2018-03)
Reactive astrogliosis, a complex process characterized by cell hypertrophy and upregulation of components of intermediate filaments, is a common feature in brains of Alzheimer's patients. Reactive astrocytes are found in ... -
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Fernández-Valenzuela, Juan José; De Castro Carratalá, Vanessa; Mejías-Ortega, Marina; Gómez-Arboledas, Ángela; Jimenez, Sebastian; Sanchez-Mico, Maria Virtudes; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; Baglietto-Vargas, David; Vizuete, Marisa; Dávila-Cansino, José Carlos; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (Frontiers, 2021-11-04)
Synaptic dysfunction and loss have been established as the pathological features that best correlate with the early cognitive decline in Alzheimer’s disease (AD). At the histopathological level, post mortem AD brains exhibit ... -
Postprandial hypertriglyceridemia predicts improvement in insulin resistance in obese patients after bariatric surgery.
Tinahones-Madueño, Francisco José; Queipo Ortuño, Maria Isabel; Clemente-Postigo, María Mercedes; Fernandez-García, Diego; Mingrone, Geltrude; Cardona-Díaz, Fernando[et al.] (Elsevier, 2013)
Morbidly obese patients have associated diseases, such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Bariatric surgery improves these obesity-related co-morbidities, including insulin resistance. ... -
Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents.
Navarro-Lobato, Irene; Masmudi-Martín, Mariam; López-Aranda, Manuel Francisco; López-Téllez, Juan Félix; Delgado, Gloria; Granados-Durán, Pablo; Gaona-Romero, Celia; Carretero-Rey, Marta; Posadas, Sinforiano; Quirós-Ortega, María Elena; Khan, Zafaruddin[et al.] (Wolters Kluwer Medknow, 2023-11-08)
Memory deficit, which is often associated with aging and many psychiatric, neurological, and neurodegenerative diseases, has been a challenging issue for treatment. Up till now, all potential drug candidates have failed ... -
Protocol: an improved method to quantify activation of systemic acquired resistance (SAR)
Rufián Plaza, José Sebastián; Rueda-Blanco, Javier; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (BMC (Springer Nature), 2019-02-14)
Background: Plant responses triggered upon detection of an invading pathogen include the generation of a number of mobile signals that travel to distant tissues and determine an increased resistance in distal, uninfected ... -
Protocol: low cost fast and efficient generation of molecular tools for small RNA analysis.
López-Márquez, Diego; Del-Espino, Ángel; Rodríguez-Bejarano, Eduardo; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (Springer Nature, 2020-03-20)
Small RNAs are sequence-dependent negative regulators of gene expression involved in many relevant plant processes such as development, genome stability, or stress response. Functional characterization of sRNAs in plants ... -
Reactive astrocyte nomenclature, definitions, and future directions.
Escartin, Carole; Galea, Elena; Lakatos, András; O`Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhäuser, Christian; Volterra, Andrea; Carmignoto, Giorgo; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei-Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Diaz-Castillo, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Götz, Magdalena; Gutiérrez-Pérez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Lino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; Lee, Justin C.; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Mural, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stéphane H.R.; Oliveira, Joao F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Perez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina-Beate; Wood, Levi B.; Wu, Jiagin; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael; Verkhratsky, Alexei[et al.] (Springer Nature, 2021-02-15)
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, ... -
Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis
Suardíaz García, Margarita; Clemente, Diego; Marín Bañasco, Carmen; Órpez, Teresa; Hurtado-Guerrero, Isaac; Pavía-Molina, José; Pinto-Medel, Maria Jesús; De Castro, Fernando; Leyva-Fernández, Laura; Fernández Fernández, Óscar; Oliver-Martos, Begoña[et al.] (Elsevier, 2016)
Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the ... -
Regulation of plant immunity via small RNA-mediated control of NLR expression
López-Márquez, Diego; Del Espino Pérez, Ángel; Ruiz-Albert, Francisco Javier; Rodríguez-Bejarano, Eduardo; Brodersen, Peter; Beuzón-López, Carmen del Rosario[et al.] (Oxford University Press, 2023-10-13)
Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered ... -
Role of a Gαi2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
López-Aranda, Manuel Francisco; Acevedo, Maria J.; Gutiérrez-Pérez, Antonia; Koulen, Peter; Khan, Zafaruddin (The Company of Biologists, 2007-07-01)
Treatment of D2-receptor-expressing cells with specific drugs upregulates the receptor number at the cell surface independently of protein synthesis, leading to the concept of an intracellular receptor pool. However, how ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
(The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Pérez-Berlanga, José Manuel; Mullor-Vigo, Rosa; Zambrana-Infantes, Emma; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (Elsevier, 2023)
Combining physical and cognitive training has been suggested to promote further benefits on brain and cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
Clemente-Postigo, María Mercedes; Muñoz Garach, Araceli; Serrano, Marta; Garrido-Sánchez, Lourdes; Bernal-López, María Rosa; Fernandez-García, Diego; Moreno Santos, Inmaculada; Garriga, Nuria; Castellano-Castillo, Daniel; Camargo, Antonio; Fernández Real, José M; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Endocrine Society, 2015)
Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ... -
Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice
(Wiley, 2015-09)Alzheimer's disease (AD) is a progressive neurological disorder that impairs memory and other cognitive functions in the elderly. The social and financial impacts of AD are overwhelming and are escalating exponentially as ... -
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Moreno-Gonzalez, Ines; Estrada, Lisbell D; Sánchez-Mejías, Elisabeth; Soto, Claudio (Macmillan Publishers Limited, 2013-02)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. ... -
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2016-10-14)
El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment
Aliaga-Gaspar, Pablo; Hurtado-Guerrero, Isaac; Ciano-Petersen, Nicolas Lundahl; Urbaneja, Patricia; Brichette Mieg, Isabel; Virginia Reyes, Virginia; Rodríguez-Bada, José Luis; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Quintana, Ester; Ramió-Torrentà, Lluis; Alonso, Ana; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (2021-12)
Protein and mRNA levels of sIFNAR2 increased after IFN-b treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated ... -
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León, Juan Antonio; Kumar, Manoj; Boon, Ruben; Chau, David; One, Jennifer; Wolfs, Esther; Eggermont, Kristel; Berckmans, Pieter; Gunhanlar, Nilhan; de Vrij, Femke; Lendemeijer, Bas; Pavie, Benjamin; Corthout, Nikky; Kushner, Steven A; Dávila-Cansino, José Carlos; Lambrichts, Ivo; Hu, Wei-Shou; Verfaillie, Catherine M[et al.] (Elsevier, 2018-02)
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel ... -
Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model
(Elsevier, 2022-01)Alzheimer's disease (AD) causes progressive age-related defects in memory and cognitive function and has emerged as a major health and socio-economic concern in the US and worldwide. To develop effective therapeutic ... -
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease
Trujillo-Estrada, Laura Isabel; Vanderklish, Peter; Minh Thu Nguyen, Marie; Kuang, Run Rong; Nguyen, Caroline; Huynh, Eric; da Cunha, Celia; Ibarra Javonillo, Dominic; Forner, Stefania; Martini, Alessandra C.; Sarraf, Stella; Simmon, Vicent; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Elsevier, 2021-10)
Alzheimer’s disease (AD) is conceptualized as a synaptic failure disorder in which loss of glutamatergic synapses is a major driver of cognitive decline. Thus, novel therapeutic strategies aimed at regenerating synapses ...