Listar BCGF - Artículos por título
Mostrando ítems 138-157 de 183
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Recombinant soluble IFN receptor (sIFNAR2) exhibits intrinsic therapeutic efficacy in a murine model of Multiple Sclerosis
Suardíaz García, Margarita; Clemente, Diego; Marín Bañasco, Carmen; Órpez, Teresa; Hurtado-Guerrero, Isaac; Pavía-Molina, José
; Pinto-Medel, Maria Jesús; De Castro, Fernando; Leyva-Fernández, Laura; Fernández Fernández, Óscar; Oliver-Martos, Begoña[et al.] (Elsevier, 2016)
Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the ... -
Regulation of plant immunity via small RNA-mediated control of NLR expression
López-Márquez, Diego; Del Espino Pérez, Ángel; Ruiz-Albert, Francisco Javier; Rodríguez-Bejarano, Eduardo; Brodersen, Peter; Beuzón-López, Carmen del Rosario[et al.] (Oxford University Press, 2023-10-13)
Plants use different receptors to detect potential pathogens: membrane-anchored pattern recognition receptors (PRRs) activated upon perception of pathogen-associated molecular patterns (PAMPs) that elicit pattern-triggered ... -
Role of a Gαi2 protein splice variant in the formation of an intracellular dopamine D2 receptor pool.
López-Aranda, Manuel Francisco; Acevedo, Maria J.; Gutiérrez-Pérez, Antonia; Koulen, Peter; Khan, Zafaruddin (The Company of Biologists, 2007-07-01)
Treatment of D2-receptor-expressing cells with specific drugs upregulates the receptor number at the cell surface independently of protein synthesis, leading to the concept of an intracellular receptor pool. However, how ... -
Sequence-dependent trafficking and activity of GDE2, a GPI-specific phospholipase promoting neuronal differentiation.
(The Company of Biologist, 2020-02-10)GDE2 (also known as GDPD5) is a multispanning membrane phosphodiesterase with phospholipase D-like activity that cleaves select glycosylphosphatidylinositol (GPI)-anchored proteins and thereby promotes neuronal differentiation ... -
Sequential treadmill exercise and cognitive training synergistically increase adult hippocampal neurogenesis in mice
Ávila-Gámiz, Fabiola; Pérez-Cano, Ana María; Pérez-Berlanga, José Manuel; Mullor-Vigo, Rosa; Zambrana-Infantes, Emma; Santín-Núñez, Luis Javier; Ladrón de Guevara-Miranda, David[et al.] (Elsevier, 2023)
Combining physical and cognitive training has been suggested to promote further benefits on brain and cognition, which could include synergistic improvement of hippocampal neuroplasticity. In this paper, we investigated ... -
Serum 25-Hydroxyvitamin D and Adipose Tissue Vitamin D Receptor Gene Expression: Relationship with Obesity and Type 2 Diabetes
Clemente-Postigo, María Mercedes; Muñoz Garach, Araceli; Serrano, Marta; Garrido-Sánchez, Lourdes; Bernal-López, María Rosa; Fernandez-García, Diego; Moreno Santos, Inmaculada; Garriga, Nuria; Castellano-Castillo, Daniel; Camargo, Antonio; Fernández Real, José M; Cardona-Díaz, Fernando; Tinahones-Madueño, Francisco José; Macías-González, Manuel[et al.] (Endocrine Society, 2015)
Context: The relationship between 25-hydroxyvitamin D [25(OH)D] and obesity and type 2 diabetes is not completely understood. Vitamin D receptor (VDR) expression in adipose tissue (AT) is related to obesity and might be ... -
Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease
Moreno-Gonzalez, Ines; Estrada, Lisbell D; Sánchez-Mejías, Elisabeth; Soto, Claudio (Macmillan Publishers Limited, 2013-02)
Several epidemiological studies have shown that cigarette smoking might alter the incidence of Alzheimer’s disease. However, inconsistent results have been reported regarding the risk of Alzheimer’s disease among smokers. ... -
Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.
Sánchez-Mejías, Elisabeth; Navarro, Victoria; Jiménez, Sebastián; Sanchez-Mico, Maria Virtudes; Sánchez-Varo, Raquel María; Núñez-Díaz, Cristina; Trujillo-Estrada, Laura Isabel; Dávila-Cansino, José Carlos; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Springer Nature, 2016-10-14)
El papel de la microglía en la enfermedad de Alzheimer (AD) aún no ha sido esclarecido. En este trabajo demostramos la existencia de una débil respuesta microglial en el hipocampo de pacientes, en contraste con la masiva ... -
Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment
Aliaga-Gaspar, Pablo; Hurtado-Guerrero, Isaac; Ciano-Petersen, Nicolas Lundahl; Urbaneja, Patricia; Brichette Mieg, Isabel; Virginia Reyes, Virginia; Rodríguez-Bada, José Luis; Alvarez-Lafuente, Roberto; Arroyo, Rafael; Quintana, Ester; Ramió-Torrentà, Lluis; Alonso, Ana; Leyva-Fernández, Laura; Fernández-Fernández, Óscar; Oliver-Martos, Begoña[et al.] (2021-12)
Protein and mRNA levels of sIFNAR2 increased after IFN-b treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated ... -
SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells.
García-León, Juan Antonio; Kumar, Manoj; Boon, Ruben; Chau, David; One, Jennifer; Wolfs, Esther; Eggermont, Kristel; Berckmans, Pieter; Gunhanlar, Nilhan; de Vrij, Femke; Lendemeijer, Bas; Pavie, Benjamin; Corthout, Nikky; Kushner, Steven A; Dávila-Cansino, José Carlos; Lambrichts, Ivo; Hu, Wei-Shou; Verfaillie, Catherine M[et al.] (Elsevier, 2018-02)
Scarce access to primary samples and lack of efficient protocols to generate oligodendrocytes (OLs) from human pluripotent stem cells (hPSCs) are hampering our understanding of OL biology and the development of novel ... -
Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model
(Elsevier, 2022-01)Alzheimer's disease (AD) causes progressive age-related defects in memory and cognitive function and has emerged as a major health and socio-economic concern in the US and worldwide. To develop effective therapeutic ... -
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease
Trujillo-Estrada, Laura Isabel; Vanderklish, Peter; Minh Thu Nguyen, Marie; Kuang, Run Rong; Nguyen, Caroline; Huynh, Eric; da Cunha, Celia; Ibarra Javonillo, Dominic; Forner, Stefania; Martini, Alessandra C.; Sarraf, Stella; Simmon, Vicent; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Elsevier, 2021-10)
Alzheimer’s disease (AD) is conceptualized as a synaptic failure disorder in which loss of glutamatergic synapses is a major driver of cognitive decline. Thus, novel therapeutic strategies aimed at regenerating synapses ... -
Squamous cell carcinoma related with dental implants. A clinical cases report.
Granados, Francisco; Santos-Ruiz, Leonor; Contreras, Marian; Mellado, José; Martín, Gregorio; Bermudo, Lucas; Ruiz, Francisco; Aguilar, Yolanda; Yáñez, Ignacio; Yáñez, Ignacio[et al.] (Medicina Oral S.L., 2020-01)
One third of all cases of head and neck carcinoma (CA) concern the oral mucosa. The use of dental implants (DI) for dental rehabilitation is widely extended. However, a few studies have reported some cases with neoplasic ... -
Stem Cell-Derived Oligodendroglial Cells for Therapy in Neurological Diseases.
García-León, Juan Antonio; Verfaillie, Catherine M. (Bentham Science, 2016-07)
There are an important number of neurological diseases where not neurons but glia are the responsible cells for the degeneration of the nervous system. In the last years, determinant roles for oligodendrocytes (OLs) have ... -
Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
(Springer Nature, 2016-04)Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA). ATX-LPA signalling is involved in multiple biological and pathophysiological processes, including vasculogenesis, fibrosis, cholestatic pruritus and ... -
Sudden cessation of fluoxetine before alcohol drinking reinstatement alters microglial morphology and TLR4/inflammatory neuroadaptation in the rat brain
Aranda, Jesús; Fernández-Arjona, María del Mar; Alén, Francisco; Rivera, Patricia; Rubio, Leticia; Smith-Fernández, Inés María[et al.] (SPRINGER, 2021-07-08)
Preclinical studies on the efects of abrupt cessation of selective serotonin reuptake inhibitors (SSRIs), a medication often prescribed in alcohol use disorder (AUD) patients with depression, results in alcohol consumption ... -
Suppression of NLR-mediated plant immune detection by bacterial pathogens.
Rufián Plaza, José Sebastián; Rueda-Blanco, Javier; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier (Oxford University Press, 2023)
The plant immune system is constituted of two functionally interdependent branches that provide the plant with an effective defense against microbial pathogens. They can be considered separate since one detects ... -
Surface nitridation improves bone cell response to melt-derived bioactive silicate/borosilicate glass composite scaffolds
Orgaz, Felipe; Dzika, A.; Szycht, O.; Amat, Daniel; Barba, Flora; Becerra-Ratia, José; Santos-Ruiz, Leonor[et al.] (Elsevier, 2016-01-01)
Novel bioactive amorphous glass-glass composite scaffolds (ICIE16/BSG) with interconnected porosity have been developed. Hierarchically interconnected porous glass scaffolds were prepared from a mixture of two melt-derived ... -
Synergistic effect of Si-hydroxyapatite coating and VEGF adsorption on Ti6Al4V-ELI scaffolds for bone regeneration in an osteoporotic bone environment
Izquierdo-Barba, Isabel; Santos-Ruiz, Leonor; Becerra-Ratia, José; Feito, M.J.; Fernández-Villa, D.; Serrano, M.C.; Díaz-Güemes, I.; Fernández-Tomé, B.; Enciso, S.; Sánchez-Margallo, F.M.; Monopoli, Donato; Alfonso, H.; Portolés, María Teresa; Arcos, Daniel; Vallet-Regí, M.[et al.] (Elsevier, 2019-01-01)
The osteogenic and angiogenic responses to metal macroporous scaffolds coated with silicon substituted hydroxyapatite (SiHA) and decorated with vascular endothelial growth factor (VEGF) have been evaluated in vitro and in ...