Listar BCGF - Artículos por título
Mostrando ítems 163-182 de 187
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Tau underlies synaptic and cognitive deficits for type 1, but not type 2 diabetes mouse models.
Trujillo-Estrada, Laura Isabel
; Nguyen, Cassidy; Da Cunha, Celia; Cai, Lena; Forner, Stefania; Martini, Alessandra C.; Ager, Rahasson; Prieto, Gilberto Aleph; Cotman, Carl; Baglietto-Vargas, David; LaFerla, Frank[et al.] (Wiley, 2019-02-27)
Diabetes mellitus (DM) is one of the most devastating diseases that currently affects the aging population. Recent evidence indicates that DM is a risk factor for many brain disorders, due to its direct effects on ... -
The Arabidopsis E3 ubiquitin ligase PUB4 regulates BIK1 and is targeted by a bacterial type‐III effector
(EMBO Press, 2022)Plant immunity is tightly controlled by a complex and dynamic regulatory network, which ensures optimal activation upon detection of potential pathogens. Accordingly, each component of this network is a potential target ... -
The bacterial effector HopZ1a acetylates MKK7 to suppress plant immunity
Rufián Plaza, José Sebastián; Rueda-Blanco, Javier; López-Márquez, Diego; Macho, Alberto P.; Beuzón-López, Carmen del Rosario; Ruiz-Albert, Francisco Javier[et al.] (Wiley, 2021)
The Pseudomonas syringae type III secretion system translocates effector proteins into the host cell cytosol to suppress plant basal immunity. Effector HopZ1a suppresses local and sys- temic immunity triggered by ... -
The C2 Protein from the Geminivirus Tomato Yellow Leaf Curl Sardinia Virus Decreases Sensitivity to Jasmonates and Suppresses Jasmonate-Mediated Defences
Rosas-Díaz, Tábata Victoria; Macho, Alberto P; Beuzón-López, Carmen del Rosario; Lozano Durán, Rosa; Rodríguez-Bejarano, Eduardo (MDPI, 2016-01)
An increasing body of evidence points at a role of the plant hormones jasmonates (JAs) in determining the outcome of plant-virus interactions. Geminiviruses, small DNA viruses infecting a wide range of plant species ... -
The C4 protein from Tomato yellow leaf curl virus can broadly interact with Plant receptor-like kinases
(MDPI, 2019-10)Plant receptor-like kinases (RLKs) exert an essential function in the transduction of signals from the cell exterior to the cell interior, acting as important regulators of plant development and responses to environmental ... -
The efficacy of natalizumab in patients with multiple sclerosis according to level of disability: results of an observational study.
Fernández Fernández, Óscar; Papais Alvarenga, Marcos; Guerrero, Miguel; León, Antonio; Alonso, Ana; López-Madrona, Jose Carlos; Leyva-Fernández, Laura; Oliver-Martos, Begoña; De Ramón, Enrique; Luque, Gloria; Fernández, Victoria[et al.] (Sage Publications, 2010-11-18)
Background: Little is known about how the level of disability at the start of treatment with natalizumab affects its efficacy. Objectives: The aim of this study was to investigate the effect of natalizumab on relapses in ... -
The emerging British Verticillium longisporum population consists of aggressive Brassica pathogens.
Depotter, Jasper; Rodríguez-Moreno, Luis Gabriel; Thomma, Bart; Wood, Thomas (American Phytopathological Society, 2017-08-28)
Verticillium longisporum is an economically important fungal pathogen of brassicaceous crops that originated from at least three hybridization events between different Verticillium spp., leading to the hybrid lineages ... -
The interspecific fungal hybrid Verticillium longisporum displays subgenome-specific gene expression
Depotter, Jasper; van Beveren, Fabian; Rodríguez-Moreno, Luis Gabriel; Kramer, Martin; Chavarro Carrero, Edgar; Florin, Gabriel; Van den Berg, Grardy; Wood, Thomas; Thomma, Bart; Seidl, Michael[et al.] (American Society for Microbiology, 2021-08)
Hybridization is an important evolutionary mechanism that can enable organisms to adapt to environmental challenges. It has previously been shown that the fungal allodiploid species Verticillium longisporum, the causal ... -
The median eminence as the hypothalamic area involved in rapid transfer of glucose to the brain: functional and cellular mechanisms.
Martínez, Fernando; Cifuentes-Rueda, Manuel; Tapia, Juan Carlos; Nualart, Francisco (Springer Nature, 2019-08)
Our data proposes that glucose is transferred directly to the cerebrospinal fluid (CSF) of the hypothalamic ventricular cavity through a rapid "fast-track-type mechanism" that would efficiently stimulate the glucosensing ... -
The receptor-like kinases BAM1 and BAM2 are required for root xylem patterning
(PNAS, 2021-02)Xylem patterning in the root is established through the creation of opposing gradients of miRNAs and their targets, transcripts of the HD-ZIP III family of transcriptions factors, enabled by the cell-to-cell spread of the ... -
The transcriptional regulator JAZ8 interactswith the C2 protein from geminivirusesand limits the geminiviral infection in Arabidopsis
Rosas-Díaz, Tábata Victoria; Cana Quijada, José Francisco; Wu, Mengshi; Hui, Du; Fernández‐Barbero, Gemma; Macho, Alberto P.; Solano, Roberto; Castillo-Garriga, Araceli; Wang, Xiao-Wei; Lozano-Durán, Rosa; Rodríguez-Bejarano, Eduardo[et al.] (Wiley, 2023)
Jasmonates (JAs) are phytohormones that finely regulate critical biological processes, including plant development and defense. JASMONATE ZIM-DOMAIN (JAZ) proteins are crucial transcriptional regulators that keep JA-responsive ... -
The viral silencing suppressor P19 interacts with the receptor-like kinases BAM1 and BAM2 and suppresses the cell-to-cell movement of RNA silencing independently of its ability to bind sRNA
(New Phytologist Foundation, 2020-10)Taken together, our results shed new light onto the molecular mechanisms underpinning the role of P19 in silencing suppression, and uncover BAM1/2 as proteins convergently targeted by independently evolved plant viruses, ... -
Three LysM effectors of Zymoseptoria tritici collectively disarm chitin-triggered plant immunity.
Tian, Hui; MacKenzie, Craig; Rodríguez-Moreno, Luis Gabriel; Van den Berg, Grardy; Chen, Hongxin; Rudd, Jason; Mesters, Jeroen; Thomma, Bart[et al.] (British Society for Plant Pathology, 2021-04-01)
Chitin is a major structural component of fungal cell walls and acts as a microbe- associated molecular pattern (MAMP) that, on recognition by a plant host, triggers the activation of immune responses. To avoid the activation ... -
Traditional Medicinal Plants as a Source of Inspiration for Osteosarcoma Therapy.
Kazantseva, Liliya; Becerra-Ratia, José; Santos-Ruiz, Leonor (MDPI, 2022-08-06)
Osteosarcoma is one of the most common types of bone cancers among paediatric patients. Despite the advances made in surgery, chemo-, and radiotherapy, the mortality rate of metastatic osteosarcoma remains unchangeably ... -
TRAIL and TRAIL receptors splice variants during long-term interferon β treatment of patients with multiple sclerosis: evaluation as biomarkers for therapeutic response
López-Gómez, Carlos; Oliver-Martos, Begoña; Pinto-Medel, María Jesús; Suardíaz García, Margarita; Reyes-Garrido, Virginia; Urbaneja, Patricia; Fernández-Fernández, Óscar; Leyva-Fernández, Laura[et al.] (BMJ Journals, 2016)
Objective We aimed to assess the effects of interferon β (IFNβ) treatment on the expression of the splice variants of the Tumour necrosis factor-Related Apoptosis Inducing Ligand (TRAIL) and its receptors in different cell ... -
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis
López-Gómez, Carlos; Fernández, Oscar; García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Suardíaz-García, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Leyva-Fernández, Laura[et al.] (Public Library of Science, 2011-07)
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce ... -
Transcriptomic Analysis in Strawberry Fruits Reveals Active Auxin Biosynthesis and Signaling in the Ripe Receptacle.
Estrada Johnson, Elizabeth; Csukasi, Fabiana; Martín-Pizarro, Carmen; Vallarino, José G.; Kiryakova, Yulia; Vioque, Amalia; Brumós, Javier; Medina-Escobar, Nieves; Botella-Mesa, Miguel Ángel; Alonso, José M.; Fernie, Alisdair R.; Sánchez-Sevilla, José F.; Osorio-Algar, Sonia; Valpuesta-Fernández, Victoriano[et al.] (Frontiers, 2017-05-29)
The role of auxin in ripening strawberry (Fragaria ×ananassa) fruits has been restricted to the early stages of development where the growth of the receptacle is dependent on the delivery of auxin from the achenes. At later ... -
Transfer and engineering of immune receptors to improve recognition capacities in crops
Rodríguez-Moreno, Luis Gabriel; Song, Yin; Thomma, Bart (Elsevier Ltd, 2017-08)
Immune receptors are pivotal elements of the plant immune system that act as sentinels for microbial invasion. Knowingly or unknowingly, breeding for resistance has largely relied on the transfer of immune receptor recognition ... -
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sánchez-Varo, Raquel María; Mejías-Ortega, Marina; Fernández-Valenzuela, Juan José; Núñez-Díaz, Cristina; Cáceres Palomo, Laura; Vegas-Gómez, Laura; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Moreno-González, Inés; García-León, Juan Antonio; Vizuete, María Luisa; Vitorica Ferrández, Javier; Baglietto-Vargas, David; Gutiérrez-Pérez, Antonia[et al.] (IOAP-MPDI, 2022-05-12)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations ...