Listar BCGF - Artículos por fecha de publicación
Mostrando ítems 1-20 de 161
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IFNAR1 and IFNAR2 polymorphisms confer susceptibility to multiple sclerosis but not to interferon-beta treatment response.
Leyva-Fernández, Laura
; Fernández-Fernández, Óscar; Fedetz, María; Blanco, Eva; Fernández, Victoria E.; Oliver-Martos, Begoña; León, Antonio; Pinto-Medel, María Jesús; Mayorga Mayorga, Cristobalina; Guerrero, Miguel; Luque, Gloria; Alcina, Antonio; Matesanz, Fuencisla[et al.] (Elsevier, 2005-04-22)
We investigated the role of three polymorphisms in the IFNAR1 (SNPs 18417 and -408) and IFNAR2 (SNP 11876) genes in multiple sclerosis (MS) susceptibility and in the IFNβ treatment response in a group of 147 patients and ... -
Interferon receptor expression in multiple sclerosis patients
Oliver-Martos, Begoña; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; León, Antonio; Luque, Gloria; C Lopez, Juan; Tamayo, Jose A; Pinto-Medel, Maria Jesús; De Ramón, Enrique; Blanco, Eva; Alonso, Ana; Fernández Fernández, Óscar[et al.] (Elsevier, 2006)
To determine the gene expression of IFNAR1, IFNAR2 and MxA protein and the association with IFNbeta treatment response in MS patients. MS patients treated with IFNbeta had a significant decrease in IFNAR1 and IFNAR2 ... -
Localization of the GoLoco motif carrier regulator of G-protein signalling 12 and 14 proteins in monkey and rat brain
López-Aranda, Manuel Francisco; Acevedo, Maria J.; Carballo, Francisco J.; Gutiérrez-Pérez, Antonia; Khan, Zafaruddin (WILEY, 2006-06)
Regulator of G-protein signalling (RGS)12 and -14 proteins possess the RGS domain, Ras-binding domains and the GoLoco motif. Emerging evidence suggests that these proteins are involved in several cellular functions in ... -
Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer’s Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic.
Jiménez, Sebastián; Baglietto-Vargas, David; Caballero, Cristina; Moreno-González, Inés; Torres, Manuel; Sánchez-Varo, Raquel María; Ruano, Diego; Vizuete, Marisa; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Society for Neuroscience, 2008)
Although the microglial activation is concomitant to the Alzheimer's disease, its precise role (neuroprotection vs neurodegeneration) has not yet been resolved. Here, we show the existence of an age-dependent phenotypic ... -
Activation of caspase-3 pathway by expression of sGαi2 protein in BHK cells.
López-Aranda, Manuel Francisco; Navarro-Lobato, Irene; López-Téllez, Juan Félix; Blanco-Calvo, Eduardo; Masmudi-Martín, Mariam; Khan, Zafaruddin[et al.] (Elsevier, 2008)
Treatment with dopamine and other dopamine D2 receptor agonists has been shown to induce cell death through activation of caspase-3 pathway. However, initial step that leads to the activation of caspase-3 in D2 receptor-mediated ... -
Absence of LPA1 signaling results in defective cortical development
Estivill-Torrús, Guillermo; Llebrez Zayas, Pedro; Matas-Rico, Elisa; Rodríguez de Fonseca, Fernando; Chun, Jerold; Santín-Núñez, Luis Javier; Pedraza-Benítez, María del Carmen; De-Diego-Barbado, Isabel; Del Arco-Herrera, Ignacio; Fernández-Llebrez, Pedro[et al.] (Oxford academy, 2008-04)
Lysophosphatidic acid (LPA) is a simple phospholipid with extracellular signaling properties mediated by specific G protein-coupled receptors. At least 2 LPA receptors, LPA(1) and LPA(2), are expressed in the developing ... -
Neutralizing antibodies against IFN beta in patients with multiple sclerosis: a comparative study of two cytopathic effect tests (CPE) for their detection
Oliver-Martos, Begoña; Orpez, Teresa; Mayorga Mayorga, Cristobalina; Leyva-Fernández, Laura; López-Gómez, Carlos; Marín, Carmen; Luque, Gloria; Fernández Fernández, Óscar[et al.] (Elsevier, 2009)
The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the ... -
Behavioral phenotype of maLPA1-null mice: increased anxiety-like behavior and spatial memory deficits
Santín-Núñez, Luis Javier; Bilbao, Ainhoa; Pedraza-Benítez, María del Carmen; Matas-Rico, Elisa; López-Barroso, Diana; Castilla-Ortega, María Estela; Sánchez-López, Jorge; Riquelme, Raquel; Varela Nieto, Isabel; de la Villa, P.; Surdiaz, Margarita; Chun, Jerold; Rodríguez de Fonseca, Fernando; Estivill-Torrús, Guillermo[et al.] (Wiley, 2009-11)
Lysophosphatidic acid (LPA) has emerged as a new regulatory molecule in the brain. Recently, some studies have shown a role for this molecule and its LPA1 receptor in the regulation of plasticity and neurogenesis in the ... -
Effect of apolipoprotein C3 and apolipoprotein A1 polymorphisms on postprandial response to a fat overload in metabolic syndrome patients
Clemente-Postigo, María Mercedes; Queipo-Ortuño, María Isabel; Valdivieso-Felices, Pedro; Tinahones-Madueño, Francisco José; Cardona-Díaz, Fernando (Elsevier. The Canadian Society of Clinical Chemists., 2010)
Objectives: Apolipoprotein C-III (APOC3) is a component of triglyceride rich lipoproteins, and SstI polymorphism has been associated with hypertriglyceridemia. Apolipoprotein A-I (APOA1) is the major component of HDL and ... -
Analysis of the role of the type III effector inventory of Pseudomonas syringae pv. phaseolicola 1448a in interaction with the plant.
Zumaquero, Adela; Macho, Alberto P; Rufián Plaza, José Sebastián; Beuzón-López, Carmen del Rosario (American Society for Microbiology, 2010-06-23)
In Pseudomonas syringae, the type III secretion system (T3SS) is essential for disease in compatible hosts and for eliciting the hypersensitive response in incompatible hosts. P. syringae pathovars secrete a variable number ... -
Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor
Castilla-Ortega, María Estela; Sánchez-López, Jorge; Hoyo-Becerra, Carolina; Matas-Rico, Elisa; Zambrana-Infantes, Emma; Chun, Jerold; Rodríguez de Fonseca, Fernando; Pedraza-Benítez, María del Carmen; Estivill-Torrús, Guillermo; Santín-Núñez, Luis Javier[et al.] (Elsevier, 2010-07)
Lysophosphatidic acid (LPA) is a new, intercellular signalling molecule in the brain that has an important role in adult hippocampal plasticity. Mice lacking the LPA1 receptor exhibit motor, emotional and cognitive ... -
Calretinin Interneurons are Early Targets of Extracellular Amyloid-beta Pathology in PS1/AbetaPP Alzheimer Mice Hippocampus.
Baglietto-Vargas, David; Moreno-González, Inés; Sánchez-Varo, Raquel María; Jiménez, Sebastián; Trujillo-Estrada, Laura Isabel; Sánchez-Mejías, Elisabeth; Torres, Manuel; Romero-Acebal, Manuel; Ruano, Diego; Vizuete, Marisa; Vitorica, Javier; Gutiérrez-Pérez, Antonia[et al.] (IOS Press, 2010-07-08)
Specific neuronal networks are preferentially affected in the early stages of Alzheimer’s disease (AD). The distinct subpopulations of hippocampal inhibitory GABAergic system have been shown to display differential ... -
The efficacy of natalizumab in patients with multiple sclerosis according to level of disability: results of an observational study.
Fernández Fernández, Óscar; Papais Alvarenga, Marcos; Guerrero, Miguel; León, Antonio; Alonso, Ana; López-Madrona, Jose Carlos; Leyva-Fernández, Laura; Oliver-Martos, Begoña; De Ramón, Enrique; Luque, Gloria; Fernández, Victoria[et al.] (Sage Publications, 2010-11-18)
Background: Little is known about how the level of disability at the start of treatment with natalizumab affects its efficacy. Objectives: The aim of this study was to investigate the effect of natalizumab on relapses in ... -
Gene expression in IFNß signalling pathway differs between monocytes, CD4 and CD8 T cells from MS patients
Oliver-Martos, Begoña; Órpez, Teresa; Pinto-Medel, Maria Jesús; Mayorga Mayorga, Cristobalina; García-León, Juan Antonio; Maldonado-Sanchez, Rafael; Suardíaz García, Margarita; Guerrero, Miguel; Luque, Gloria; Leyva-Fernández, Laura; Fernández Fernández, Óscar[et al.] (Elsevier, 2011)
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged ... -
Adipose tissue gene expression of factors related to lipid processing in obesity
Clemente-Postigo, María Mercedes; Queipo Ortuño, María Isabel; Fernandez-García, Diego; Gómez-Huelgas, Ricardo; Tinahones, Francisco J; Cardona, Fernando[et al.] (PLOS One, 2011)
Background Adipose tissue lipid storage and processing capacity can be a key factor for obesity-related metabolic disorders such as insulin resistance and diabetes. Lipid uptake is the first step to adipose tissue lipid ... -
Kinetics and incidence of anti-natalizumab antibodies in multiple sclerosis patients on treatment for 18 months.
Oliver-Martos, Begoña; Fernández, Óscar; Orpez, Teresa; Alvarenga, Marco Papais; Pinto-Medel, María Jesús; Guerrero, Miguel; León, Antonio; López-Madrona, José Carlos; Maldonado-Sánchez, Rafael; García-León, Juan Antonio; Luque, Gloria; Fernández, Victoria; Leyva-Fernández, Laura[et al.] (SAGE, 2011-03)
Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing-remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that ... -
Geminiviruses Subvert Ubiquitination by Altering CSN-Mediated Derubylation of SCF E3 Ligase Complexes and Inhibit Jasmonate Signaling in Arabidopsis thaliana
Lozano-Durán, Rosa; Rosas-Díaz, Tábata Victoria; Gusmaroli, Giuliana; Pérez-Luna, Ana Isabel; Taconnat, Ludivine; Wang Deng, Xing; Rodríguez-Bejarano, Eduardo[et al.] (Oxford Academy, 2011-03)
Viruses must create a suitable cell environment and elude defense mechanisms, which likely involves interactions with host proteins and subsequent interference with or usurpation of cellularmachinery. Here, we describe a ... -
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jiménez, Sebastián; Torres, Manuel; Vizuete, Marisa; Sánchez-Varo, Raquel María; Sánchez-Mejías, Elisabeth; Trujillo-Estrada, Laura Isabel; Carmona-Cuenca, Irene; Caballero, Cristina; Ruano, Diego; Gutiérrez-Pérez, Antonia; Vitorica, Javier[et al.] (Elsevier, 2011-05)
Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have ... -
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis
López-Gómez, Carlos; Fernández, Oscar; García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Suardíaz-García, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Alvarez-Lafuente, Roberto; Urcelay, Elena; Leyva-Fernández, Laura[et al.] (Public Library of Science, 2011-07)
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce ... -
Identification of Host Genes Involved in Geminivirus Infection Using a Reverse Genetics Approach
Lozano Durán, Rosa; Rosas-Díaz, Tábata Victoria; Pérez-Luna, Ana Isabel; Rodríguez-Bejarano, Eduardo (PlosONE, 2011-07-26)
Geminiviruses, like all viruses, rely on the host cell machinery to establish a successful infection, but the identity and function of these required host proteins remain largely unknown. Tomato yellow leaf curl Sardinia ...