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dc.contributor.authorMañas Padilla, María del Carmen
dc.contributor.authorÁvila-Gámiz, Fabiola
dc.contributor.authorGil-Rodriguez, Sara
dc.contributor.authorLadrón de Guevara-Miranda, David
dc.contributor.authorRodriguez-de-Fonseca, Fernando
dc.contributor.authorSantin-Nuñez, Luis Javier 
dc.contributor.authorCastilla-Ortega, Maria Estela 
dc.date.accessioned2021-08-26T11:29:56Z
dc.date.available2021-08-26T11:29:56Z
dc.date.issued2021
dc.identifier.urihttps://hdl.handle.net/10630/22747
dc.description.abstractRepeated cocaine exposure induces lasting neurobehavioral adaptations such as cognitive decline in animal models. However, persistent changes in spontaneous –unconditioned- motor and exploratory responses are scarcely reported. In this study, mice were administered with cocaine (20 mg/kg/day) or vehicle for 12 consecutive days. After 24 days of drug abstinence, a behavioral assessment was carried out in drug-free conditions and in unfamiliar environments (i.e. no cocaine-associated cues were presented). The cocaine-withdrawn mice showed cognitive deficits in spontaneous alternation behavior and place recognition memory. Importantly, they also displayed hyperlocomotion, increased rearing activity and altered exploratory patterns in different tasks. In the forced swimming test, they were more active (struggled/climbed more) when trying to escape from the water albeit showing normal immobility behavior. In conclusion, in addition to cognitive deficits, chronic cocaine in rodents may induce long-lasting alterations in exploratory activity and psychomotor activation that are triggered even in absence of drug-related stimuli.es_ES
dc.description.sponsorshipThis study was funded by grants from the Spanish Ministry of Economy and Competitiveness (MINECO, Agencia Estatal de Investigación –AEI-) cofounded by the European Regional Development Fund-FEDER, UE- (PSI2015–73,156-JIN to E.C–O.; PSI2017–82604R to L.J.S.), RETICS Red de Trastornos Adictivos (ERDF-EU; RD16/0017/0001 to F.R.F.) and University of Málaga (B4: ‘Ayudas para Proyectos Puente’to E.C–O). Funding for open access charge: Universidad de Málaga /CBUA. Authors M.C.M-P., F. A-G. and S. G-R. hold predoctoral grants from the Spanish Ministry of Science, Innovation and Universities (FPU17/00276 to M.C.M-P.; PRE2018–085673 to F.A-G.; and FPU18/00941 to S.G-R.). Author D.L.G.M. holds a postdoctoral grant from University of Málaga (A.3. Plan Propio de Investigación y Transferencia Universidad de Málaga).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectAnsiedades_ES
dc.subject.otherAnxietyes_ES
dc.subject.otherElevated plus mazees_ES
dc.subject.otherSpatial working memoryes_ES
dc.subject.otherPlace recognition memoryes_ES
dc.subject.otherForced swimminges_ES
dc.titlePersistent changes in exploration and hyperactivity coexist with cognitive impairment in mice withdrawn from chronic cocainees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.centroFacultad de Psicologíaes_ES
dc.identifier.doi10.1016/j.physbeh.2021.113542
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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