Biología Molecular y Bioquímica - (BMB)
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Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María
; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
NTMC2T5.1 is involved in chloroplast clustering around nucleus in Nicotiana benthamiana.
Plants have developed mechanisms to protect themselves from pathogens and resist their attacks. Among these, clustering of chloroplasts around the nuclear envelope is a phenomenon that has been proposed as a general response ... -
Role of ripe fruit epidermis-specific FvMYB29-FvbHLH transcription factor complexes in strawberry
Sánchez-Gómez, Carlos; Perotti, María Florencia; Meco, Victoriano; Domínguez, Eva; Heredia-Bayona, Antonio; Bayer, Emmanuelle M.; Franco-Zorilla, José M.; Martín-Pizarro, Carmen; Posé-Padilla, David[et al.] (2023-07-09)
Transcriptome changes during strawberry fruit ripening have been previously reported. However, we have identified genes with tissue- and stage-specific patterns in the receptacles of Fragaria vesca coupling LCM with RNA-seq ... -
Adaptative mechanisms of cellulose synthesis under stress conditions
Pagano Márquez, Raquel; Macho, Alberto; Castillo-Garriga, Araceli; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel (2023-07-09)
Cellulose is the main structural compound of the plant cell wall and the most abundant biopolymer on Earth (Bar‐On et al 2018). The essential role of cellulose in plant development and defence highlights the importance ... -
Rising to the Challenge: Developing Biosensors to Study Nitrogen Transport in Plants
Nitrogen (N) plays a crucial role in plant development and growth, which is why high concentrations of N in the form of fertilizers are commonly used in agricultural crops. However, the excess N present in fertilizers is ... -
Antiangiogenic potential of an anthraquinone metabolite isolated from a marine fungus.
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2023)
The potential of marine organisms to yield bioactive molecules is vast and largely unexplored. Significantly, certain bioactive compounds derived from the marine environment have already received approval as anticancer ... -
Peripheral membrane TTL proteins safeguard cellulose synthesis under stress.
Amorim-Silva, Vitor; García-Moreno, Álvaro; Kesten, Christopher; Menna, Alexandra; Castillo-Garriga, Araceli; Percio Vargas, Francisco; Pagano-Márquez, Raquel; Moya-Cuevas, José; Armengot, Laia; Ruiz-López, Noemí; Jallais, Yvon; Sánchez-Rodríguez, Clara; Botella-Mesa, Miguel Ángel[et al.] (2023)
Land plants provide around eighty percent of biomass on Earth and roughly one-third corresponds to cellulose (Bar-On et al 2018). Despite its biological and societal importance, many aspects of cellulose biosynthesis and ... -
Pining for answers: Study of cationic amino acids (CATs) transport in maritime pine Pinus pinaster Aiton.
Medina Morales, Beatriz; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Castro Rodríguez, Vanessa Viviana (2023)
Amino acid (AA) transporters are membrane proteins involved in AA mobilization within and between cells and cells compartments. In plants, these transporters are responsible of AA transport from sink to source organelle/cell ... -
Phosphorylation regulates cellulose biosynthesis regulation.
Percio Vargas, Francisco; Toth, Ryan; DeFalco, Thomas A.; Persson, Staffan; Zipfel, Cyril; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel[et al.] (2023)
Plants comprise over 82% of all biomass on Earth, a third of which is cellulose, making it the most abundant organic compound¹. Cellulose is also essential for plant development and defense against multiple stresses. ... -
Under pressure: Abies pinsapo Boiss, queen of the response to high temperature and water stress.
Blanca Reyes, Irene Victoria; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Castro Rodríguez, Vanessa Viviana (2023)
The Spanish fir (Abies pinsapo Boiss) is an ecologically and economically important conifer species, but little is known about its molecular responses to abiotic stresses related to climate change. The study of molecular ... -
Selected problems/cases to stimulate collaborative learning regarding the dynamic flexibility of metabolism.
Metabolic reprogramming has been identified as one of the hallmarks of cancer. Furthermore, it is becoming more and more frequent to establish connection between other diseases and metabolic rewiring. One of us has recently ... -
The Extra Virgin Olive Oil phenolic compounds () oleacein and () oleocanthal inhibit tumor cell autophagy
Marrero Capitán, Ana Dácil; Posligua-García, Joel; Bernal, Manuel; Ortega Vidal, Juan; Salido, Sofía; Altarejos, Joaquín; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2023)
Our group has recently shown that the antitumor Extra Virgin Olive Oil phenolic compounds (—)oleocanthal and (—)oleacein also behave as antiangiogenic agents. Interestingly, it has been described that phenolic compounds ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
Monterde, Beatriz; Rojano Rivera, María Elena; Córdoba Caballero, Jose; Seoane Zonjic, Pedro; Perkins, James Richard; Medina-Torres, Miguel Ángel; García-Ranea, Juan Antonio[et al.] (Elsevier, 2023)
Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; Sánchez López, José María; Trigal Martínez, Mónica; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2023-05-15)
The role played by a sustained angiogenesis in cancer and other diseases stimulates the interest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence that 1,8- dihydroxy-9,10-anthraquinone ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
(Frontiers Media, 2022-04-25)The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Three component-based bi-layer and ecofriendly mulching films.
Sanchez, Laura Mabel; Benitez, José Jesús; Domínguez Carmona, Eva María; Heredia-Bayona, Antonio (2023)
Among the agronomic practices usually employed to achieve more successful culture results, mulching (M) has been applied using a variety of materials. In particular, the employment of plastic M films has made a revolution ...