Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 1-20 de 399
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A central role for bifunctional aspartate/prephenate aminotransferase in the biosynthesis of amino acids in plant plastids.
El-Azaz-Ciudad, Jorge; Cánovas-Ramos, Francisco Miguel
; De-la-Torre-Fazio, Fernando Nicolás; Ávila-Sáez, Concepción (2014-06-27)
A central role for bifunctional aspartate/prephenate aminotransferase in the biosynthesis of amino acids in plant plastids. Fernando de la Torre, Jorge El-Azaz, Concepción Ávila, Francisco M. Cánovas Departamento de ... -
A course-based undergraduate research experience to illustrate the early stages of the drug discovery process
García-Caballero, Melissa; Moya-García, Aurelio Ángel; Torres-Vargas, José Antonio; García-Ponce, Ángel Luis; Rodríguez-Quesada, Ana María (Wiley, 2022-07-12)
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research experience (CURE) to involve undergraduate students of Science in a real-world scientific problem. Within the topic “Let's ... -
A network biology approach to novel therapeutic estrategies
(2017-05-30)Network and systems biology offer a novel way of approaching drug discovery by developing models that consider the global physiological environment of protein targets, and the effects of modifying them, without losing the ... -
A revised view on the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Hirel, Bertrand; Cantón, Francisco R.; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2022-02)
Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of histamine and serotonin in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-14)
Polyamines (putrescine, spermidine and spermine; PAs) are required for the survival of the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine ... -
A role for antizyme inhibitor 2 in the biosynthesis and content of serotonin and histamine in mouse mast cells
Acosta-Andrade, Carlos; Lambertos, Ana; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Peñafiel, Rafael; Fajardo-Paredes, Ignacio José[et al.] (2015-09-04)
Polyamines (putrescine, spermidine and spermine; PAs) are essential for the majority of living cells. Antizymes and antizyme inhibitors are key regulatory proteins of PA levels by affecting ornithine decarboxylase and PA ... -
A workflow with dedicated tools for preparing reference transcriptomes from non-model organisms has evidenced important biological information
Claros-Díaz, Manuel Gonzalo; Benzekri, Hicham; Seoane, Pedro; Carmona Muñoz, Rosario Maria; Bautista-Moreno, Rocío; Guerrero-Fernández, Darío; Fernández-Pozo, Noé[et al.] (2014-10-01)
Construction transcriptomes of non-model organisms is a common task nowadays due to the advent of low-cost sequencing platforms. The non-model organisms require a de novo assembling strategy since no reference is available. ... -
Actividad del Sistema Renina-Angiotensina en relación con sus polimorfismos genéticos
(Servicio de Publicaciones y Divulgación Científica, 2000)La realización del presente estudio sobre sujetos jóvenes y sanos no hipertensos tiene dos objetivos primordiales: El primero es analizar la relación de los polimorfismos de los genes del Sistema Renina-Angiotensina, el ... -
AD0157, a pyrrolidinedione fungal metabolite, inhibits angiogenesis by targeting the Akt signaling pathway
García-Caballero, Melissa; Cañedo, Librada; Fernández-Medarde, Antonio; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (2014-09-16)
In the course of a screening program for the inhibitors of angiogenesis from marine sources, AD0157, a pyrrolidinedione fungal metabolite, was selected for its angiosupressive properties. AD0157 inhibited the growth of ... -
Adaptative mechanisms of cellulose synthesis under stress conditions
Pagano Márquez, Raquel; Macho, Alberto P.; Castillo-Garriga, Araceli; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel (2023-07-09)
Cellulose is the main structural compound of the plant cell wall and the most abundant biopolymer on Earth (Bar‐On et al 2018). The essential role of cellulose in plant development and defence highlights the importance ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Algunos aspectos de la evolución de la familia génica de glutamina sintetasa en plantas
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Hirel, Bertrand; Ruiz-Canton, Francisco Javier; Cañas-Pendón, Rafael Antonio[et al.] (2022)
En las plantas, la actividad glutamina sintetasa reside en miembros de la superfamilia GSII, que forman dos grupos de enzimas GS funcionales: la GSIIb eubacteriana (GLN2) y la GSIIe eucariota (GLN1/GS). Los análisis ... -
Allelic variation of MYB10 is the major force controlling natural variation in skin and flesh color in strawberry (Fragaria spp.) fruit
Castillejo, Cristina; Waurich, Veronika; Wagner, Henning; Ramos, Rubén; Oiza, Nicolás; Muñoz, Pilar; Triviño, Juan C; Caruana, Julie; Liu, Zhongchi; Cobo, Nicolás; Hardigan, Michael A; Knapp, Steven J; Vallarino Castro, José G.; Osorio-Algar, Sonia; Martín-Pizarro, Carmen; Pose-Padilla, David; Toivainen, Tuomas; Hytönen, Timo; Oh, Youngjae; Barbey, Christopher R; Whitaker, Vance M; Lee, Seonghee; Olbricht, Klaus; Sánchez-Sevilla, José F; Amaya Saavedra, Iraida[et al.] (2021-11-26)
Fruits of diploid and octoploid strawberry (Fragaria spp.) show substantial natural variation in both skin and flesh color due to distinct anthocyanin accumulation and distribution patterns. Expression of structural genes ... -
Allelic Variation of MYB10 is the Major Force Controlling Natural Variation of Skin and Flesh Color in Strawberry (Fragaria spp.) fruit
Castillejo, Cristina; Waurich, Veronika; Wagner, Henning; Ramos, Rubén; Oiza, Nicolás; Muñoz, Pilar; Triviño, Juan C; Caruana, Julie; Liu, Zhongchi; Cobo, Nicolás; Hardigan, Michael A; Knapp, Steven J; Vallarino Castro, José G.; Osorio-Algar, Sonia; Martín-Pizarro, Carmen; Pose-Padilla, David; Toivainen, Tuomas; Hytönen, Timo; Oh, Youngjae; Barbey, Christopher R; Whitaker, Vance M; Lee, Seonghee; Olbricht, Klaus; Sánchez-Sevilla, José F; Amaya Saavedra, Iraida[et al.] (2020-06-13)
Anthocyanins are the principal color-producing compounds synthesized in developing fruits of strawberry (Fragaria spp.). Substantial natural variation in color have been observed in fruits of diploid and octoploid accessions, ... -
Alteration of TCA in transgenic tomato plants shows a crucial role of organic acids in crop development and fruit quality
Jiménez, Lidia; Pott, Delphine; Martinez-Ferri, Elsa; Vallarino Castro, José G.; Osorio-Algar, Sonia (2018-07-12)
Tomato (Solanum lycopersicum) is second most consumed vegetable in the world, but also a model plant for the study of fleshy fruit ripening and senescence owing to its genetic and molecular tractability. Organic acids play ... -
Aminooxi análogos de histidina: una posible estrategia para modular la histidina descarboxilasa humana.
Sánchez-Jiménez, Francisca María (2014-09-26)
La histamina (Hia) es una amina biógena implicada en procesos fisiológicos esenciales (respuesta inmune, neurotransmisión y otros). El desequilibrio de su metabolismo juega un destacado papel en muchas patologías. El control ... -
Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex
Ortigosa, Francisco; Lobato-Fernández, César; Shikano, Hitomi; Ávila-Sáez, Concepción; Taira, Shu; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2021-11-01)
Ammonium is a prominent source of inorganic nitrogen for plant nutrition, but excessive amounts can be toxic for many species. However, most conifers are tolerant to ammonium, a relevant physiological feature of this ancient ... -
Ammonium uptake, transport and nitrogen economy in forest trees
Cánovas-Ramos, Francisco Miguel; Ávila-Sáez, Concepción; De-la-Torre-Fazio, Fernando Nicolás; Cañas-Pendón, Rafael Antonio; Pascual-Moreno, María Belén; Castro-Rodríguez, Vanessa Viviana; El-Azaz-Ciudad, Jorge[et al.] (2016-09-02)
AMMONIUM UPTAKE, TRANSPORT AND NITROGEN ECONOMY IN FOREST TREES Francisco M. Cánovas, Concepción Avila, Fernando N. de la Torre, Rafael A. Cañas, Belén Pascual, Vanessa Castro- Rodríguez, Jorge El-Azaz Departamento ... -
An ecological model of invasion and metastasis
Serrano, José J.; Urdiales-Ruiz, José Luis; Medina-Torres, Miguel Ángel; Montañez, Raúl (2017-08-29)
It has been argued that malignat tumours represent complex dynamic and self-organizing ecosystems. Furthermore, there is increasing evidence that collective cell migration occurs during invasion and metastasis. Here, we ... -
Análisis Bioinformático del Transcriptoma del Pino
(UMA Editorial, 2021-09-17)Las especies del género Pinus son de gran interés económico y ecológico en todo el mundo, y especialmente en el hemisferio norte. Sin embargo estas especies carecen de un genoma secuenciado debido a la complejidad y los ...