Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 287-306 de 358
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Ratones knock-out del receptor lpa1 de ácido lisofosfatídico presentan un acusado déficit de la isoenzima glutaminasa KGA (GLS) y una morfología alterada en las espinas dendríticas de hipocampo y corteza
Peñalver, Ana; Campos-Sandoval, Jose Angel
; Sanchez-Varo, Raquel Maria; Cardona, Carolina; Castilla, Laura; Blanco, Eduardo; Martín-Rufián, Mercedes; Segura-Checa, Juan Antonio; Mates-Sanchez, Jose Manuel; Alonso-Carrion, Francisco Jose; Gutierrez-Perez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (2015-09-25)
Objectives: The objective of the present study was to utilize mice with knocked-down lysophosphatidic acid 1 (LPA1) receptor to ascertain changes in glutamatergic transmission that may help to explain part of the cognitive ... -
Regulación coordinada de los genes implicados en la síntesis de fenilalanina en pino
Craven-Bartle, Blanca; Pascual-Moreno, Maria Belen; Canovas-Ramos, Francisco Miguel; Avila-Saez, Concepcion (2013-11-04)
Regulación coordinada de los genes implicados en la síntesis de Fenilalanina en pino Craven-Bartle B, Pascual MB, Cánovas FM, Avila C Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Campus ... -
Regulación Transcripciones del Gen GLS2 y Obtención de Células Madre Embrionarias Transformadas para Generación de Ratones Knockout
(Servicio de Publicaciones y Divulgación Científica, 2016)La enzima glutaminasa activada por fosfato (GA) cataliza la hidrólisis del grupo amido de la glutamina (Gln) para rendir glutamato (Glu) y amonio. Esta enzima es esencial para el ciclo Gln-Glu entre neuronas y astrocitos ... -
REGULATION OF VITAMIN C BIOSYNTHESIS IN HIGHER PLANTS
Fenech Torres, Mario; Amorim-Silva, Vitor; Castillo, Araceli G.; Esteban del Valle, Alicia; Valpuesta-Fernandez, Victoriano; Smirnoff, Nicholas; Botella-Mesa, Miguel Angel[et al.] (2019-05-15)
Ascorbate, also known as vitamin C, plays fundamental roles in biotic and abiotic stress resistance in plants. In green tissues, ascorbate is mainly synthesized through the Smirnoff-Wheeler pathway, whose regulation is not ... -
Regulation of Vitamin C content in higher plants
Fenech-Torres, Mario; Amorim-Silva, Vitor; Smirnoff, Nicholas; Botella-Mesa, Miguel Angel (2017-06-23)
Ascorbic Acid (AsA, vitamin C) has multiple biological roles in plants. Although several pathways for the novo synthesis of AsA have been reported, it is the L-Gal, also known as the Smirnoff-Wheeler (SW), the main pathway ... -
Regulation versus deregulation: an evolutionary perspective on the biochemical control of amino acids biosynthesis in plants
El-Azaz, Jorge; De-la-Torre-Fazio, Fernando Nicolas; Urbano-Gámez, Jose Alberto; Barcelona, Belen; Avila-Saez, Concepcion; Canovas-Ramos, Francisco Miguel[et al.] (2019-07-23)
Amino acids are essential compounds for all the living organisms. Along with their central role as constituents of proteins, in plants they also act as precursors of a myriad of compounds and meta- bolites with critical ... -
Repercusiones renales del ejercicio físico intenso. Estudio bioquímico-antropométrico en nadadores adolescentes
(Universidad de Málaga, Servicio de Publicaciones, 1997)Con el objetivo de conocer las repercusiones renales del ejercicio físico intenso en nadadores adolescentes tras la realización de un test de campo en un medio de entrenamiento habitual, se determinaron las tasas de ... -
Role and therapeutic potential of dietary ketone bodies in lymph vessel growth
(2021-06-02)Lymphatic vessels (LVs), lined by lymphatic endothelial cells (LECs), are indispensable for life. However, the role of metabolism in LECs has been incompletely elucidated. In our study, it is reported that LEC-specific ... -
Role of Arabidopsis DGK1 and DGK2 in cold stress
García-Hernández, Selene; Ruiz-Lopez, Noemi; Botella-Mesa, Miguel Angel (2022-09-14)
There are regions, present in all eukaryotic cells, where the membranes of two different organelles are very close (10-30nm), but without fusion, due to proteins which act as tether. These regions are named Membrane Contact ... -
Role of enhancer activity and chromatin architecture on the regulation and evolution of developmental gene expression: The HoxD cluster paradigm.
(2022)Los genes Hox, también conocidos como genes arquitecto por su papel en la especificación del bauplan de vertebrados e invertebrados, se expresan en distintas combinaciones en varias estructuras embrionarias. Estudiando la ... -
Role of glucose, glutamine and palmitate in endothelial and tumor metabolism
Ocaña, Mª Carmen; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2016-12-22)
Glucose and glutamine are the major sources of energy for mammalian cells. In tumors, Warburg effect and glutaminolysis have been largely studied. On the other hand, a major role of glucose in angiogenesis has been ... -
Role pf TTLs proteins in cellulose biosynthesis
García-Moreno, Álvaro; Amorim-Silva, Vitor; Valpuesta-Fernandez, Victoriano; Macho, Alberto; Jaillais, Yvon; Botella-Mesa, Miguel Angel[et al.] (2018-07-18)
Abiotic stress cause detrimental yield losses in crop species. Plants are sessile organisms, so the understanding of the plant cell wall, which is the most important component that constitute the plant biomass of crop ... -
Root and shoot growth of Pinus strobus x P. wallichiana somatic plants is influenced by the nitrogen composition of the germination medium
Llebrés, Maria Teresa; Pascual-Moreno, Maria Belen; Canovas-Ramos, Francisco Miguel; Avila-Saez, Concepcion; Klimaszewska K (2013-11-07)
Somatic embryogenesis (SE) in conifers has proven to be an useful biotechnological tool for species conservation and mass propagation, but to make it commercially viable, adaptive research is required to convert laboratory ... -
Scaffold-mediated Assembly of the Brassinosteroid Signaling Components by TTL proteins
Amorim-Silva, Vitor; García-Moreno, Álvaro; Lakhssassi, Naoufal; Esteban, Alicia; Rosado Rey, Abel; Pérez-Sancho, Jessica; Li, Yansha; Castillo, Araceli G; Perez-Rodriguez, Josefa; Valpuesta-Fernandez, Victoriano; Zipfel, Cyril; Macho, Alberto; Botella-Mesa, Miguel Angel[et al.] (2017-06-23)
Brassinosteroids (BRs) is a group of steroidal hormones that play critical roles in multiple aspects of plant growth and development. BR stimulation at the PM receptors initiates a series of phosphorylation events enabling ... -
Screening of Synergic Interactions of Anti-Angiogenic and Anti-Tumor Compounds
García-Vilas García, Javier Alejandro; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (2015-09-30)
Solid cancers have several common characteristics that Hanahan & Weinberg named as the hallmarks of cancer. Angiogenesis is an essential hallmark of cancer because tumor cells need oxygen and nutrients delivered by the ... -
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; García-Vilas García, Javier Alejandro (Elsevier, 2016-07)
Purpose: To screen for possible synergistic interactions of epigallocatechin-3-gallate (EGCG) with a selection of 10 anti-angiogenic or anti-tumor compounds on the survival of endothelial and tumor cells. Methods: Human ... -
Search of candidate genes involved in branched-chain amino acid metabolism in strawberry: functional validation
Romero, Helena; Pott, Delphine Maya; Segado, Enrique; Vallarino Castro, José G.; Osorio-Algar, Sonia (2022)
Cultivated strawberry (Fragaria × ananassa) is a berry crop widely appreciated worldwide due to its nutritional and organoleptic properties. However, the main breeding targets in these crops have been the control of ... -
Secretory Profile of Adipose-Tissue-Derived Mesenchymal Stem Cells from Cats with Calicivirus-Positive Severe Chronic Gingivostomatitis
Villatoro, Antonio J.; Martín Astorga, María del Carmen; Alcoholado Cueto, Cristina; Kazantseva, Liliya; Cardenas, Casimiro; Fariñas, Fernando; Becerra-Ratia, Jose; Visser, Rick[et al.] (IOAP-MPDI, 2022-05-25)
The feline calicivirus (FCV) causes infections in cats all over the world and seems to be related to a broad variety of clinical presentations, such as feline chronic gingivostomatitis (FCGS), a severe oral pathology in ... -
Sensitivity of polyamine metabolism to glucose deprivation is increased in neuroblastoma cells with N-myc amplification
Ruiz-Pérez, M. Victoria; Urdiales-Ruiz, Jose Luis; Sanchez-Jimenez, Francisca Maria; Medina, Miguel Ángel (2014-07-10)
Ornithine-derived polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. Neuroblastoma, the most frequent extra-cranial solid tumor in children, harbors amplification of n-myc ... -
Síndrome de deficiencia de Coenzima Q10
(2017-05-31)Desde 1984 he estado interesado en estudiar las funciones y los mecanismos moleculares de la síntesis de coenzima Q, su regulación y su implicación en la organización y funcionamiento de la cadena respiratoria. En los ...