Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 364-383 de 399
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Targeted gene modification in Fragaria vesca mediated by CRISPR/Cas9 system
Genome editing is becoming an important biotechnological tool for gene function analysis and crop improvement, being the CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat-CRISPR associated protein 9) ... -
Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System
Martín-Pizarro, Carmen; Duarte-Conde, José Antonio; Pose-Padilla, David
(2018-07-12)
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
The art of sequence alignment
(2014-02-12)Sequence similarity: why are we interested in, how do you define it Scoring metrics: what is important in similarity Scoring with DNA: integrating biological knowledge Scoring with proteins: integrating biological ... -
The coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cells
Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María; Cárdenas García, Casimiro (SEBBM, 2013-09-04)
Although epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated ... -
The enzymatic determination of glucose in carbonated beverages: a useful tool for the undergraduate students to learn the basis of enzymatic analysis and the comparison of two analytical methods
García-Ponce, Ángel Luis; Martínez-Póveda, Beatriz Amparo; Blanco-López, Ángel; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2017-03-20)
The importance of enzymatic analysis in biochemistry, clinical chemistry and food chemistry is undoubted. The course "Applied Biochemistry" in our Faculty is aimed to undergraduate students of Chemistry and Biochemistry. ... -
The Extra Virgin Olive Oil phenolic compounds () oleacein and () oleocanthal inhibit tumor cell autophagy
Marrero Capitán, Ana Dácil; Posligua-García, Joel; Bernal, Manuel; Ortega Vidal, Juan; Salido, Sofía; Altarejos, Joaquín; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2023)
Our group has recently shown that the antitumor Extra Virgin Olive Oil phenolic compounds (—)oleocanthal and (—)oleacein also behave as antiangiogenic agents. Interestingly, it has been described that phenolic compounds ... -
The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal-Valenzuela, Isabel; Fernández-Florido, Elena; Marrero Capitán, Ana Dácil; Castilla, Laura; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2022)
Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is ... -
The molecular control of tomato fruit quality traits: the trade off between visual attributes, shelf life and nutritional value
Carneiro, RT; Lytovchenko, A; McQuinn, R; Vallarino Castro, José G.; Giovannoni, James J.; Fernie, Alisdair R; Rose, JKC; Osorio-Algar, Sonia[et al.] (2013-07-19)
Tomato (Solanum lycopersicum) is an established model to study fleshy fruit development and ripening and is an important crop in terms of its economic and nutritional value. Tomato fruit quality is a function of metabolite ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino Castro, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Pillet, Jeremy; Casañal, Ana; Merchante-Berg, Catharina; Amaya Saavedra, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J.; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Pose-Padilla, David[et al.] (Oxford University Press, 2021-02-24)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF is a key regulator of fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino Castro, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Merchante-Berg, Catharina; Amaya Saavedra, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J.; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Pose-Padilla, David[et al.] (2021-11-26)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of strawberry, a non-climacteric fruit, is still limited. NAC transcription factors are proteins that mediate ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
The role of DGK1 and DGK2 in Membrane Contact Sites and Stress Tolerance
García Hernández, Selene; Ruiz-López, Noemí; Botella-Mesa, Miguel Ángel (2023-06-05)
All eukaryotic cells present regions where the membranes of two different organelles are very close (10-30 nm) without fusion, mediated by tether proteins. These regions are known as Membrane Contact Sites (MCS). Contact ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
Carrillo Fernández, Paloma; Bernal Muñoz, Manuel; Téllez Quijorna, Clara; Marrero Capitán, Ana Dácil; Vidal-Valenzuela, Isabel; Castilla, Laura; Caro Salazar, Carlos; Domínguez Moreno, Alejandro; García-Martín, María Luisa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (Elsevier, 2022-12-14)
Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ... -
Three component-based bi-layer and ecofriendly mulching films.
Sanchez, Laura Mabel; Benitez, José Jesús; Domínguez Carmona, Eva María; Heredia-Bayona, Antonio (2023)
Among the agronomic practices usually employed to achieve more successful culture results, mulching (M) has been applied using a variety of materials. In particular, the employment of plastic M films has made a revolution ... -
Transcript profiling of wood transcriptional regulators, wood chemistry and phenotyping in poplar and eucalyptus genotypes growgin under drought, salinity and limiting nitrogen conditions
Molina-Rueda, Juan Jesús; Garrido-Aranda, Alicia; Sixto, Hortensia; Sánchez, Mario; Cañellas, Isabel; López, Gustavo; Simoes, Rita; Mounet, Fabien; Alia, Ricardo; Leple, Jean-Charles; Grima-Pettenati, Jacqueline; Rodrígues, José; Gallardo-Alba, Fernando; Cantón, Francisco R.[et al.] (2014-06-11)
The possibilities for using lignocellulosic biomass produced from forest crops in order to obtain second generation biofuels is a key issue in the current context of climate change and the promotion of renewable energy ... -
Transcriptional regulation os phenylalaline biosynthesis and utilization
Pascual-Moreno, María Belén; Cañas-Pendón, Rafael Antonio; Craven-Bartle, Blanca; Cánovas-Ramos, Francisco Miguel; Ávila-Sáez, Concepción (2016-06-29)
Conifer trees divert large quantities of carbon into the biosynthesis of phenylpropanoids, particularly to generate lignin, an important constituent of wood. Since phenylalanine is the precursor for phenylpropanoid ... -
Transcriptional regulatory network controlling strawberry fruit ripening and quality
Martín-Pizarro, Carmen; Lucas Reina, Eva; Trapero Mozos, Almudena; Meco, Victoriano; Sánchez-Gómez, Carlos; Vallarino Castro, José G.; De Luis Balaguer, María Angels; Rambla, José Luis; Toivainen, Tuomas; Sozzani, Rosangela; Granell, Antonio; Hytönen, Timo; Pose-Padilla, David; Osorio-Algar, Sonia; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano[et al.] (2019-01-31)
Ripening is a critical step for the development of flavor quality in fruits. This character has significantly declined in many fleshy fruits over recent decades. This is particularly significant in strawberry (Fragaria × ... -
Transcriptome Analysis and Intraspecific Variation in Spanish Fir (Abies pinsapo Boiss.)
Ortigosa Peña, Francisco; Ávila-Sáez, Concepción; Rubio-Valverde, Lourdes; Álvarez-Garrido, Lucía; Carreira de la Fuente, José Antonio; Cañas-Pendón, Rafael Antonio; Cánovas-Ramos, Francisco Miguel[et al.] (IOAP-MPDI, 2022-08-19)
Spanish fir (Abies pinsapo Boiss.) is an endemic, endangered tree that has been scarcely investigated at the molecular level. In this work, the transcriptome of Spanish fir was assembled, providing a large catalog of ... -
Transcriptomics of ammonium nutrition in the conifer Pinus pinaster Aiton
Ortigosa, Francisco; Lobato-Fernández, César; Valderrama-Martín, José Miguel; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (2019-07-10)
Nitrogen is an important element for all living beings because it is part of macromolecules as significant as nucleic acids or amino acids. For plants, it constitutes a limiting factor in their growth and development1 due ... -
Translation dynamics of the plant-virus interaction
Sans-Coll, Gemma; Castillo-Garriga, Araceli; Rodríguez-Béjarano, Eduardo; Merchante, Catharina (2023)
Tomato yellow leaf curl virus (TYLCV) causes a disease that gives rise to massive damage to tomato crops world-wide (Prasad et al., 2020). As a virus, it requires the host’s cellular machinery to be able to infect, which ...