Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 454-473 de 511
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Targeted gene modification in Fragaria vesca mediated by CRISPR/Cas9 system
Genome editing is becoming an important biotechnological tool for gene function analysis and crop improvement, being the CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat-CRISPR associated protein 9) ... -
Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System
Martín-Pizarro, Carmen; Duarte-Conde, José Antonio; Posé-Padilla, David
(2018-07-12)
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
(BMC, 2017-06-19)La metástasis linfática es una de las principales causas de muerte en pacientes con diferentes tipos de cáncer y es el principal factor pronóstico para la supervivencia de la enfermedad. La formación de nuevos vasos ... -
The Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 Gene Is Involved in Anisotropic Root Growth during Osmotic Stress Ad.aptation
Cuadrado-Pedetti, María Belén; Rauschert, Inés; Sainz, María Martha; Amorim-Silva, Vitor; Botella-Mesa, Miguel Ángel; Borsani, Omar; Sotelo-Silveira, Mariana[et al.] (MDPI, 2021-02-07)
Mutations in the Arabidopsis TETRATRICOPEPTIDE THIOREDOXIN-LIKE 1 (TTL1) gene cause reduced tolerance to osmotic stress evidenced by an arrest in root growth and root swelling, which makes it an interesting model to explore ... -
The art of sequence alignment
(2014-02-12)Sequence similarity: why are we interested in, how do you define it Scoring metrics: what is important in similarity Scoring with DNA: integrating biological knowledge Scoring with proteins: integrating biological ... -
The coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cells
Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María; Cárdenas García, Casimiro (SEBBM, 2013-09-04)
Although epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated ... -
The enzymatic determination of glucose in carbonated beverages: a useful tool for the undergraduate students to learn the basis of enzymatic analysis and the comparison of two analytical methods
García-Ponce, Ángel Luis; Martínez-Póveda, Beatriz Amparo; Blanco-López, Ángel; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (2017-03-20)
The importance of enzymatic analysis in biochemistry, clinical chemistry and food chemistry is undoubted. The course "Applied Biochemistry" in our Faculty is aimed to undergraduate students of Chemistry and Biochemistry. ... -
The Extra Virgin Olive Oil phenolic compounds () oleacein and () oleocanthal inhibit tumor cell autophagy
Marrero Capitán, Ana Dácil; Posligua-García, Joel; Bernal, Manuel; Ortega Vidal, Juan; Salido, Sofía; Altarejos, Joaquín; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2023)
Our group has recently shown that the antitumor Extra Virgin Olive Oil phenolic compounds (—)oleocanthal and (—)oleacein also behave as antiangiogenic agents. Interestingly, it has been described that phenolic compounds ... -
The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal-Valenzuela, Isabel; Fernández-Florido, Elena; Marrero Capitán, Ana Dácil; Castilla, Laura; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (2022)
Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is ... -
The Marine Fungal Metabolite, AD0157, Inhibits Angiogenesis by Targeting the Akt Signaling Pathway
(MDPI, 2014-01-16)En el marco de un programa de selección de inhibidores de la angiogénesis de origen marino, se seleccionó AD0157, un metabolito fúngico de la pirrolidinediona, por sus propiedades angiosupresoras. AD0157 inhibió el crecimiento ... -
The molecular control of tomato fruit quality traits: the trade off between visual attributes, shelf life and nutritional value
Carneiro, RT; Lytovchenko, A; McQuinn, R; Vallarino Castro, José G.; Giovannoni, James J.; Fernie, Alisdair R; Rose, JKC; Osorio-Algar, Sonia[et al.] (2013-07-19)
Tomato (Solanum lycopersicum) is an established model to study fleshy fruit development and ripening and is an important crop in terms of its economic and nutritional value. Tomato fruit quality is a function of metabolite ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino Castro, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Pillet, Jeremy; Casañal, Ana; Merchante-Berg, Catharina; Amaya Saavedra, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J.; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Posé-Padilla, David[et al.] (Oxford University Press, 2021-02-24)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry.
Martín-Pizarro, Carmen; Vallarino, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Pillet, Jeremy; Casañal, Ana; Merchante-Berg, Catharina; Amaya, Iraida; Willmitzer, Lothar; Fernie, Alisdair R.; Giovannoni, James J.; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Posé-Padilla, David[et al.] (Oxford University Press [University Publisher], American Society of Plant Biologists [Society Publisher], 2021-02-24)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of strawberry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF is a key regulator of fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino Castro, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Merchante-Berg, Catharina; Amaya Saavedra, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J.; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Posé-Padilla, David[et al.] (2021-11-26)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of strawberry, a non-climacteric fruit, is still limited. NAC transcription factors are proteins that mediate ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
The Physcomitrium patens egg cell expresses several distinct epigenetic components and utilizes homologs of BONOBO genes for cell specification
(Wiley, 2022-02-17)Although land plant germ cells have received much attention, knowledge about their speci-fication is still limited. We thus identified transcripts enriched in egg cells of the bryophyte model species Physcomitrium patens, ... -
The role of DGK1 and DGK2 in Membrane Contact Sites and Stress Tolerance
García Hernández, Selene; Ruiz-López, Noemí; Botella-Mesa, Miguel Ángel (2023-06-05)
All eukaryotic cells present regions where the membranes of two different organelles are very close (10-30 nm) without fusion, mediated by tether proteins. These regions are known as Membrane Contact Sites (MCS). Contact ... -
The role of GDP-L-galactose phosphorylase in the control of ascorbate biosynthesis
Fenech, Mario; Amorim-Silva, Vitor; Esteban del Valle, Alicia; Arnoud, Dominique; Ruiz-López, Noemí; Castillo-Garriga, Araceli; Smirnoff, Nicholas; Botella-Mesa, Miguel Ángel[et al.] (Oxford University Press in behalf of American Society of Plant Biologists, 2021-01-25)
The enzymes involved in l-ascorbate biosynthesis in photosynthetic organisms (the Smirnoff–Wheeler [SW] pathway) are well established. Here, we analyzed their subcellular localizations and potential physical interactions ... -
The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway
Vidal-Valenzuela, Isabel; Castilla-Ruiz, Laura; Marrero-Capitán, Ana Dácil; Bravo-Ruiz, Inés; Bernal-Muñoz, Manuel; Manrique-Poyato, María Inmaculada; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Poveda, Beatriz Amparo; Vidal-Valenzuela[et al.] (MDPI, 2022)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and ... -
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis.
G. Doblas, Verónica; Amorim-Silva, Vitor; Posé-Padilla, David; Rosado, Abel; Esteban, Alicia; Arró, Montserrat; Azevedo, Herlânder; Bombarely, Aureliano; Borsani, Omar; Valpuesta-Fernández, Victoriano; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel[et al.] (American Society of Plant Biologists, 2013-02-12)
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ...