Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 325-344 de 358
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Synthesis, characterization and biological evaluation of octyltrimethylammonium tetrathiotungstate
Vega-Granados, Karla; Cruz-Reyes, Juan; Horta-marrón, José F.; Mari-Beffa, Manuel
; Díaz-Rubio, Laura; Córdova-Guerrero, Iván; Chávez-Velasco, Daniel; Ocaña, M. Carmen; Medina, Miguel Ángel; Romero-Sánchez, Lilian B.[et al.] (Springer Nature, 2021)
Octyltrimethylammonium tetrathiotungstate salt (ATT-C8) was synthesized and its ability to chelate copper was evaluated. The biological and toxic aspects were evaluated by in vitro and in vivo assays, using bovine aorta ... -
Synthetic and molecular genetic approaches in plant hormone research
(2019-09-23)Phytohormones govern plant physiology, environmental adaptation and phenotypic plasticity. Hormone auxin is critical for growth at every stage of plant’s life, from seed germination to fruit ripening. We investigated the ... -
Systems Biology Approaches to Evaluate Disease Modularity
(Universidad de Málaga, Servicio de Publicaciones y Divulgación Científica, 2014)Biological systems are in a constant process of innovation as an essential precondition to evolve. For this reason, the emergence of phenotypic variation is an inherent property of complex adaptive systems. Even though ... -
SYT mutations membrane fusions with whole plant hypersensitivity to abiotic stresses
Perez Sancho, Jessica; Rosado Rey, Abel; Botella-Mesa, Miguel Angel (2013-11-21)
Plants undergo continuous exposure to various abiotic stresses in their natural environment. For this reason they have evolved intricate mechanisms to perceive external signals and trigger the physiological changes necessary ... -
SYT6: a newly identified protein involved in ER - trans-Golgi network Membrane Contact Sites
SYT6 is a newly identified lipid transport protein from ER - trans-Golgi network Membrane Contact Sites. Our results show that: • SYT6 contacts trans-Golgi network vesicles through its coiled-coil domain. • SYT6 can ... -
Targeted gene modification in Fragaria vesca mediated by CRISPR/Cas9 system
(2016)Genome editing is becoming an important biotechnological tool for gene function analysis and crop improvement, being the CRISPR-Cas9 (Clustered Regularly Interspaced Short Palindromic Repeat-CRISPR associated protein 9) ... -
Targeted mutagenesis of FaTM6 in the Octoploid Strawberry (Fragaria x ananassa) using the CRISPR/Cas9 System
(2018-07-12)The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
The art of sequence alignment
(2014-02-12)Sequence similarity: why are we interested in, how do you define it Scoring metrics: what is important in similarity Scoring with DNA: integrating biological knowledge Scoring with proteins: integrating biological ... -
The coffee diterpene kahweol is an antitumoral compound for human estrogen receptor-negative breast cancer cells
Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria; Cárdenas, Casimiro (SEBBM, 2013-09-04)
Although epidemiological studies indicate that coffee consumption is associated with a low incidence of several kinds of cancer, there are still few studies on the anti-tumoral effects of pure bioactive compounds isolated ... -
The enzymatic determination of glucose in carbonated beverages: a useful tool for the undergraduate students to learn the basis of enzymatic analysis and the comparison of two analytical methods
García-Ponce, Ángel Luis; Martinez-Poveda, Beatriz Amparo; Blanco-Lopez, Angel; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria (2017-03-20)
The importance of enzymatic analysis in biochemistry, clinical chemistry and food chemistry is undoubted. The course "Applied Biochemistry" in our Faculty is aimed to undergraduate students of Chemistry and Biochemistry. ... -
The immunomodulator dimethyl taconite inhibits several key steps of angiogenesis in cultured endothelial cells
Vidal, Isabel; Fernández-Florido, Elena; Marrero, Ana Dácil; Castilla, Laura; Quesada, Ana R.; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel[et al.] (2022)
Dimethyl itaconate (DMI) is a cell-permeable derivative of itaconate, a known immunomodulator metabolite synthesized from the Krebs cycle intermediate cis-aconitate by the enzyme aconitate dehydrogenase. Although DMI is ... -
The molecular control of tomato fruit quality traits: the trade off between visual attributes, shelf life and nutritional value
Carneiro, RT; Lytovchenko, A; McQuinn, R; Vallarino, José G.; Giovannoni, James J; Fernie, Alisdair R; Rose, JKC; Osorio-Algar, Sonia[et al.] (2013-07-19)
Tomato (Solanum lycopersicum) is an established model to study fleshy fruit development and ripening and is an important crop in terms of its economic and nutritional value. Tomato fruit quality is a function of metabolite ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Pillet, Jeremy; Casañal, Ana; Merchante, Catharina; Amaya, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J; Botella-Mesa, Miguel Angel; Valpuesta-Fernandez, Victoriano; Posé, David[et al.] (Oxford University Press, 2021-02-24)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The NAC transcription factor FaRIF is a key regulator of fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Merchante, Catharina; Amaya, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J; Botella-Mesa, Miguel Angel; Valpuesta-Fernandez, Victoriano; Posé, David[et al.] (2021-11-26)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of strawberry, a non-climacteric fruit, is still limited. NAC transcription factors are proteins that mediate ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martinez-Poveda, Beatriz Amparo; Quesada, Ana R.; Medina, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
Transcript profiling of wood transcriptional regulators, wood chemistry and phenotyping in poplar and eucalyptus genotypes growgin under drought, salinity and limiting nitrogen conditions
Molina-Rueda, Juan Jesús; Garrido-Aranda, Alicia; Sixto, Hortensia; Sánchez, Mario; Cañellas, Isabel; Lopez, Gustavo; Simoes, Rita; Mounet, Fabien; Alia, Ricardo; Leple, Jean-Charles; Grima-Pettenati, Jacqueline; Rodrígues, José; Gallardo-Alba, Fernando; Cantón, Francisco R.[et al.] (2014-06-11)
The possibilities for using lignocellulosic biomass produced from forest crops in order to obtain second generation biofuels is a key issue in the current context of climate change and the promotion of renewable energy ... -
Transcriptional regulation os phenylalaline biosynthesis and utilization
Pascual-Moreno, Maria Belen; Cañas-Pendon, Rafael Antonio; Craven-Bartle, Blanca; Canovas-Ramos, Francisco Miguel; Avila-Saez, Concepcion (2016-06-29)
Conifer trees divert large quantities of carbon into the biosynthesis of phenylpropanoids, particularly to generate lignin, an important constituent of wood. Since phenylalanine is the precursor for phenylpropanoid ... -
Transcriptional regulatory network controlling strawberry fruit ripening and quality
Martín-Pizarro, Carmen; Lucas Reina, Eva; Trapero Mozos, Almudena; Meco, Victoriano; Sánchez-Gómez, Carlos; Vallarino, José G.; De Luis Balaguer, Maria Angels; Rambla, José Luis; Toivainen, Tuomas; Sozzani, Rosangela; Granell, Antonio; Hytönen, Timo; Posé, David; Osorio-Algar, Sonia; Botella-Mesa, Miguel Angel; Valpuesta-Fernandez, Victoriano[et al.] (2019-01-31)
Ripening is a critical step for the development of flavor quality in fruits. This character has significantly declined in many fleshy fruits over recent decades. This is particularly significant in strawberry (Fragaria × ... -
Transcriptome Analysis and Intraspecific Variation in Spanish Fir (Abies pinsapo Boiss.)
Ortigosa Peña, Francisco; Avila-Saez, Concepcion; Rubio-Valverde, Lourdes; Álvarez-Garrido, Lucía; Carreira de la Fuente, José Antonio; Cañas-Pendon, Rafael Antonio; Canovas-Ramos, Francisco Miguel[et al.] (IOAP-MPDI, 2022-08-19)
Spanish fir (Abies pinsapo Boiss.) is an endemic, endangered tree that has been scarcely investigated at the molecular level. In this work, the transcriptome of Spanish fir was assembled, providing a large catalog of ... -
Transcriptomics of ammonium nutrition in the conifer Pinus pinaster Aiton
Ortigosa, Francisco; Lobato-Fernández, César; Valderrama-Martín, José Miguel; Avila-Saez, Concepcion; Canovas-Ramos, Francisco Miguel; Cañas-Pendon, Rafael Antonio[et al.] (2019-07-10)
Nitrogen is an important element for all living beings because it is part of macromolecules as significant as nucleic acids or amino acids. For plants, it constitutes a limiting factor in their growth and development1 due ...