Listar Biología Molecular y Bioquímica - (BMB) por título
Mostrando ítems 494-513 de 536
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The Sponge-Derived Brominated Compound Aeroplysinin-1 Impairs the Endothelial Inflammatory Response through Inhibition of the NF-κB Pathway
Vidal-Valenzuela, Isabel; Castilla-Ruiz, Laura; Marrero-Capitán, Ana Dácil; Bravo-Ruiz, Inés; Bernal-Muñoz, Manuel; Manrique-Poyato, María Inmaculada; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel; Martínez-Poveda, Beatriz Amparo; Vidal-Valenzuela[et al.] (MDPI, 2022)
Aeroplysinin-1 (Apl-1) is a brominated compound isolated from the marine sponge Aplysina aerophoba that exhibits pleiotropic bioactive effects, impairing cell growth in cancer cells, inhibiting angiogenesis in vitro and ... -
The SUD1 Gene Encodes a Putative E3 Ubiquitin Ligase and Is a Positive Regulator of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Arabidopsis.
G. Doblas, Verónica; Amorim-Silva, Vitor; Posé-Padilla, David; Rosado, Abel; Esteban, Alicia; Arró, Montserrat; Azevedo, Herlânder; Bombarely, Aureliano; Borsani, Omar; Valpuesta-Fernández, Victoriano; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel[et al.] (American Society of Plant Biologists, 2013-02-12)
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme catalyzes the major rate-limiting step of the mevalonic acid (MVA) pathway from which sterols and other isoprenoids are synthesized. In contrast with our extensive ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
Carrillo Fernández, Paloma; Bernal Muñoz, Manuel; Téllez Quijorna, Clara; Marrero Capitán, Ana Dácil; Vidal-Valenzuela, Isabel; Castilla, Laura; Caro Salazar, Carlos; Domínguez Moreno, Alejandro; García-Martín, María Luisa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (Elsevier, 2022-12-14)
Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ... -
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Mates-Sánchez, José Manuel; di Paola, Floriana J.; Campos-Sandoval, José Ángel; Mazurek, Sybille; Márquez-Gómez, Javier (Elsevier, 2020-02)
Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to provide energy, biosynthetic precursors and redox requirements to allow the massive proliferation of tumor cells. Glutamine is also a ... -
Three component-based bi-layer and ecofriendly mulching films.
Sanchez, Laura Mabel; Benitez, José Jesús; Domínguez Carmona, Eva María; Heredia-Bayona, Antonio (2023)
Among the agronomic practices usually employed to achieve more successful culture results, mulching (M) has been applied using a variety of materials. In particular, the employment of plastic M films has made a revolution ... -
Toluquinol, a marine fungus metabolite, is a new angiosuppresor that interferes the Akt pathway.
García-Caballero, Melissa; Mari-Beffa, Manuel; Cañedo, Librada; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2013-06-15)
El toluquinol, una metilhidroquinona producida por un hongo marino, fue seleccionado en el curso de una selección a ciegas de nuevos inhibidores potenciales de la angiogénesis. En el presente estudio proporcionamos la ... -
Towards defining the role of translation regulation during viral infection in plants.
Sans-Coll, Gemma; Castillo-Garriga, Araceli; Rodríguez-Bejarano, Eduardo; Merchante-Berg, Catharina (2024)
Tomato yellow leaf curl virus (TYLCV) is responsible for massive damage to tomato crops worldwide (Prasad et al., 2020). Due to its viral nature, it requires the host’s cellular machinery to be able to infect, which implies ... -
Towards understanding the role of heterogeneous ribosomes in Arabidopsis. Characterization of the ribosomal protein families eL24 and eL18.
(UMA Editorial, 2024)Esta Tesis Doctoral, titulada Towards understanding the role of heterogeneous ribosomes in Arabidopsis. Characterization of the ribosomal protein families eL24 and eL18, estudia la heterogeneidad ribosomal mediada por los ... -
Towards understanding the role of heterogeneous ribosomes in Arabidopsis. Characterization of the ribosomal protein family eL24.
(2024)Translation and its regulation play an important role in plant adaptation. Despite being the key molecular machines that synthesize proteins, ribosomes have traditionally been considered passive molecular players in ... -
Transcript profiling of wood transcriptional regulators, wood chemistry and phenotyping in poplar and eucalyptus genotypes growgin under drought, salinity and limiting nitrogen conditions
Molina-Rueda, Juan Jesús; Garrido-Aranda, Alicia; Sixto, Hortensia; Sánchez, Mario; Cañellas, Isabel; López, Gustavo; Simoes, Rita; Mounet, Fabien; Alia, Ricardo; Leple, Jean-Charles; Grima-Pettenati, Jacqueline; Rodrígues, José; Gallardo-Alba, Fernando; Cantón, Francisco R.[et al.] (2014-06-11)
The possibilities for using lignocellulosic biomass produced from forest crops in order to obtain second generation biofuels is a key issue in the current context of climate change and the promotion of renewable energy ... -
Transcriptional profiling of dendritic cells in a mouse model of food-antigen induced anaphylaxis reveals the upregulation of multiple immune-related pathways.
Rodríguez, María José; Palomares, Francisca; Bogas, Gador; Torres-Jaén, María Josefa; Díaz-Perales, Araceli; Rojo, Javier; Plaza Serón, María del Carmen; Rodríguez-Nogales, Alba; Orengo, Christine A.; Mayorga, Cristobalina; Perkins, James Richard[et al.] (Wiley, 2018-10-20)
Scope Much of our knowledge about gene expression during anaphylaxis comes from candidate gene studies. Despite their potential role, expression changes in dendritic cells (DCs) have not been studied in this context using ... -
Transcriptional regulation os phenylalaline biosynthesis and utilization
Pascual-Moreno, María Belén; Cañas-Pendón, Rafael Antonio; Craven-Bartle, Blanca; Cánovas-Ramos, Francisco Miguel; Ávila-Sáez, Concepción (2016-06-29)
Conifer trees divert large quantities of carbon into the biosynthesis of phenylpropanoids, particularly to generate lignin, an important constituent of wood. Since phenylalanine is the precursor for phenylpropanoid ... -
Transcriptional regulatory network controlling strawberry fruit ripening and quality
Martín-Pizarro, Carmen; Lucas Reina, Eva; Trapero Mozos, Almudena; Meco, Victoriano; Sánchez-Gómez, Carlos; Vallarino Castro, José G.; De Luis Balaguer, María Angels; Rambla, José Luis; Toivainen, Tuomas; Sozzani, Rosangela; Granell, Antonio; Hytönen, Timo; Posé-Padilla, David; Osorio-Algar, Sonia; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano[et al.] (2019-01-31)
Ripening is a critical step for the development of flavor quality in fruits. This character has significantly declined in many fleshy fruits over recent decades. This is particularly significant in strawberry (Fragaria × ... -
Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness.
Minina, Elena A.; Moschou, Panagiotis N.; Vetukuri, Ramesh R.; Sánchez-Vera, Victoria; Cardoso, Catarina; Liu, Qinsong; Elander, Pernilla H.; Dalman, Kerstin; Beganovic, Mirela; Lindberg, Jenny; Marmon, Sofia; Shabala, Lana; Suárez-Marín, María Fernanda; Ljung, Karin; Novak, Ondrej; Shabala, Sergei; Stymne, Sten; Hofius, Daniel; Bozhkov, Peter V.[et al.] (Journal of Experimental Botany / Oxford Academic, 2018-01-20)
Autophagy is a major catabolic process whereby autophagosomes deliver cytoplasmic content to the lytic com- partment for recycling. Autophagosome formation requires two ubiquitin-like systems conjugating Atg12 with Atg5, ... -
Transcriptome Analysis and Intraspecific Variation in Spanish Fir (Abies pinsapo Boiss.)
Ortigosa Peña, Francisco; Ávila-Sáez, Concepción; Rubio-Valverde, Lourdes; Álvarez-Garrido, Lucía; Carreira de la Fuente, José Antonio; Cañas-Pendón, Rafael Antonio; Cánovas-Ramos, Francisco Miguel[et al.] (IOAP-MPDI, 2022-08-19)
Spanish fir (Abies pinsapo Boiss.) is an endemic, endangered tree that has been scarcely investigated at the molecular level. In this work, the transcriptome of Spanish fir was assembled, providing a large catalog of ... -
Transcriptomic Insight into the Pollen Tube Growth of Olea europaea L. subsp. europaea Reveals Reprogramming and Pollen-Specific Genes Including New Transcription Factors
Claros-Díaz, Manuel Gonzalo; Bullones, Amanda; Castro, Antonio Jesús; Lima-Cabello, Elena; Fernández-Pozo, Noé; Bautista-Moreno, Rocío; Alché, Juan de Dios[et al.] (Plants, 2023)
The pollen tube is a key innovation ofland plants that is essential for successful fertilisation. Its development and growth have been profusely studied in model organisms, but in spite of the economic impact of olive ... -
Transcriptomics of ammonium nutrition in the conifer Pinus pinaster Aiton
Ortigosa, Francisco; Lobato-Fernández, César; Valderrama-Martín, José Miguel; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (2019-07-10)
Nitrogen is an important element for all living beings because it is part of macromolecules as significant as nucleic acids or amino acids. For plants, it constitutes a limiting factor in their growth and development1 due ... -
TransFlow: a modular framework for assembling and assessing accurate de novo transcriptomes in non-model organisms
Claros-Díaz, Manuel Gonzalo; Seoane, Pedro; Espigares, Marina; Carmona, Rosario; Polonio, Álvaro; Quintana, Julia; Cretazzo, Enrico; Bota, Josefina; Pérez-García, Alejandro; Alché, Juan de Dios; Gómez, Luis[et al.] (BMC Bioinformatics, 2018)
The advances in high-throughput sequencing technologies are allowing more and more de novo assembling of transcriptomes from many new organisms. Some degree of automation and evaluation is required to warrant reproducibility, ... -
Transient protein-protein interactions: structural, functional, and network properties
(Elsevier, 2010-10-13)Transient interactions, which involve protein interactions that are formed and broken easily, are important in many aspects of cellular function. Here we describe structural and functional properties of transient interactions ... -
Translation dynamics of the plant-virus interaction
Sans-Coll, Gemma; Castillo-Garriga, Araceli; Rodríguez-Bejarano, Eduardo; Merchante-Berg, Catharina (2023)
Tomato yellow leaf curl virus (TYLCV) causes a disease that gives rise to massive damage to tomato crops world-wide (Prasad et al., 2020). As a virus, it requires the host’s cellular machinery to be able to infect, which ...