• Antioxidant responses related to temozolomide resistance in glioblastoma 

      Campos-Sandoval, José A.; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sanchez, Jose Manuel; Alonso, Francisco J.; [et al.] (Elsevier, 2021)
      Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ...
    • Antitumor and antiangiogenic potential of solomonamide synthesis intermediates 

      Carrilo, Paloma; Cheng-Sánchez, Iván; Ocaña, Mª Carmen; Martínez-Poveda, Beatriz; Medina, Miguel Ángel; [et al.] (2017-11-09)
      In this work we developed a new synthetic strategy towards the solomonamides. a novel class of cyclopeptides of marine origin. The described synthetic approach utilized an olefin metathesis reaction to form the [15]-membered ...
    • Aportación Bioinformática a la Biología de Especies Marinas 

      Benzekri, Hicham (UMA Editorial, 2016)
      Los recursos marinos son de gran interés económico en todo el mundo. La acuicultura es el sector de producción de alimentos de mayor crecimiento y se espera que en el futuro cercano produzca más alimento para el consumo ...
    • Application of multiomic technologies to study the environmental impact on berry fruit quality 

      Jimenez, Lidia; Pott, Delphine; Duran, Sara; Mott, Daniella; Petit, Aurélie; [et al.] (2019-01-16)
      Berries, such as strawberry, raspberry and black currant, are well appreciated for their delicate flavor and nutraceutical properties, with consumer demand increasing over the last years. However, climate change and market ...
    • Aprendizaje colaborativo y el modelo de clase invertida como ayuda para el aprendizaje del metabolismo 

      Alonso-Carrion, Francisco Jose (2018-11-09)
      Lo siguiente resume el contenido de la presentación oral que será expuesta en este Congreso dedicada a describir la base de las metodologías de aprendizaje colaborativo (AC) y de inversión de la clase (flipped learning) ...
    • Aproximaciones metabolómica y transcriptómica a la gestión del metabolismo en las acículas de Pinus pinaster L. aiton 

      Cañas, Rafael A.; Canales, Javier; Muñoz, Carmen; Granados, Jose M.; Pascual, Mª Belen; [et al.] (2014-07-14)
      Aproximaciones metabolómica y transcriptómica a la gestión del metabolismo en las acículas de Pinus pinaster L. Aiton Rafael A. Cañas1, Javier Canales1, Carmen Muñoz2, Jose M. Granados1, Ma Belén Pascual1, Concepción ...
    • Arabidopsis Synaptotagmins 1 and 3 are involved in lipid homeostasis at ER-PM contact sites under cold stress 

      Amorim-Silva, Vítor; Esteban, Alicia; Castillo Garriga, Araceli; Rosado, Abel; Vanneste, Steffen; [et al.] (2018-07-12)
      As sessile organisms, plants must cope with abiotic stress such as soil salinity, drought, and extreme temperatures. This stress signal can activate a phospholipase C (PLC), which hydrolyses PIP2 to generate IP3 and ...
    • Árboles para fitorremediación de altos niveles de nitrato y aplicaciones en bioenergía 

      Castro-Rodríguez, Vanessa; García-Gutiérrez, Ángel; Canales, Javier; Cañas, Rafael A.; Kirby, Edward G; [et al.] (2016-02-11)
      La utilización de cantidades elevadas de fertilizantes para aumentar el rendimiento de las cosechas ha conducido a la contaminación por nitratos de aguas subterráneas y superficiales. En este estudio, se presenta la ...
    • Arginine biosynthesis and utilization in maritime pine 

      Llebrés, MT; Pascual, MB; Debille, S; Trontin, JF; Harvengt, L; [et al.] (2017-10-30)
      Vegetative propagation through somatic embryogenesis in combination with the cryopreservation of embryogenic lines is a major tool in conifer biotechnology. An important process during the maturation phase of embryogenesis ...
    • The arogenate dehydratase ADT2 is essential for seed development in Arabidopsis 

      El-Azaz Ciudad, Jorge; Canovas-Ramos, Francisco Miguel; Ávila, Concepción; De la Torre Fazio, Fernando (2018-07-25)
      Phenylalanine (Phe) biosynthesis in plants is a key process, as Phe serves as precursor of proteins and phenylpropanoids. The prephenate pathway connects chorismate, final product of the shikimate pathway, with the ...
    • Aroma map in European woodland strawberry 

      Urrutia, María; Meco, Victoriano; Trapero, Almudena; Pillet, Jeremy; Rambla, José Luis; [et al.] (2019-05-10)
      Woodland strawberry (Fragaria vesca, 2x) is the diploid closest ancestor of the cultivated strawberry (Fragaria ´ annassa, 8x) and the model species for genetic studies in the Fragaria genus. It is naturally distributed ...
    • Aroma Map in European Woodland Strawberry 

      Urrutia, María; Meco, Victoriano; Martín-Pizarro, Carmen; Trapero, Almudena; Pillet, Jeremy; [et al.] (2020-01-07)
      Woodland strawberry (Fragaria vesca, 2x) is a wild, diploid ancestor of the cultivated strawberry (Fragaria ananassa, 8x), the most economically important berry crop. F. vesca is very appreciated for its intense fruity ...
    • Arquitectura nuclear e integridad del genoma 

      Rodríguez Daga, Rafael (2017-05-30)
      Nuestro laboratorio está interesado en entender los mecanismos celulares implicados en el control del espacio intracelular y la morfogénesis de la célula. Para estudiar los mecanismos que gobiernan este control a nivel ...
    • Aspectos estructurales y funcionales de la asparraginasa en pino 

      Van Kerckhoven, Sonia; De la Torre, Fernando; Pascual, María B.; Cañas, Rafael A.; Ávila, Concepción; [et al.] (2016-03-17)
      La asparragina es un metabolito clave en plantas para el transporte y reserva temporal de nitrógeno. La principal vía de movilización del nitrógeno contenido en el grupo amido de este aminoácido implica a la enzima ...
    • Los átomos de azufre próximos a los anillos de residuos aromáticos son menos susceptibles de ser oxidados 

      Aledo-Ramos, Juan Carlos; Cantón, Francisco R.; Veredas-Navarro, Francisco Javier (2015-10-05)
      El grupo tioéter de las metioninas confiere, a las proteínas portadoras, una alta vulnerabilidad a la oxidación. Sin embargo, no todos los residuos metionil de una proteína son igualmente susceptibles de oxidación. Aunque ...
    • The balance between fumarate and malate plays an important role in plant development and postharvest quality in tomato fruit 

      Jimenez, Lidia; Pott, Delphine; Martinez-Ferri, Elsa; Fernie, Alisdair R; Vallarino, Jose G; [et al.] (2018-03-21)
      Organic acids, produced as intermediates of the tricarboxylic cycle, play a crucial role in the plant primary metabolism and are considered as being ones of the most important quality traits in edible fruits. Even if they ...
    • Biochemical identification and analysis of ADT-like proteins from plants 

      De la Torre, Fernando; El-Azaz, Jorge; Ávila, Concepción; Canovas-Ramos, Francisco Miguel (2019-10-17)
      Phenylalanine (Phe) biosynthesis in plants is a fundamental process as Phe serves as a precursor of proteins but also of a massive array of essential phenylpropanoids for plant growth development defense or reproduction. ...
    • Biochemical regulation of arginine biosynthesis in plants 

      Urbano-Gámez, Alberto; El-Azaz, Jorge; De la Torre, Fernando; Avila, Concepcion; Canovas-Ramos, Francisco Miguel (2019-07-09)
      Arginine plays a relevant role in plant metabolism due to its importance as building block of proteins but also as precursor of multiple secondary metabolites, polyamines and nitric oxide. Importantly, arginine frequently ...
    • Bioinformatics analysis of Pinus pinaster Aiton transcriptome in response to ammoniacal nutrition 

      Lobato-Fernández, César (2019-07-30)
      Conifers have a great economic and environmental value. Nitrogen is an important limiting factor for the development of plants. Conifers are well adapted to ammonium nutrition since it is the main source of inorganic ...
    • Biological Functions of Mast Cells 

      Pejler, Gunnar (2017-05-05)
      Conferencia en la que se exponen los aspectos más importantes de las funciones biológicas de los mastocitos