ListarBiología Molecular y Bioquímica - (BMB) por tema "Oxidative stress"
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GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel
; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel (MDPI, 2024-06-20)
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ...