Listar Biología Molecular y Bioquímica - (BMB) por tipo "info:eu-repo/semantics/acceptedVersion"
Mostrando ítems 1-20 de 30
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A development of chimeric VEGFR2 TK inhibitor based on two ligand conformers from PDB: 1Y6A complex--medicinal chemistry consequences of a TKs analysis
Lintnerová, Lucia; García-Caballero, Melissa; Fridrich, Gregáň; Melicherčík, Milan; Rodríguez-Quesada, Ana María
; Dobiaš, Juraj; Lác, Ján; Sališová, Marta; Boháč, Andrej[et al.] (Elsevier, 2014-01-24)
El VEGFR2 es un importante mediador de la angiogénesis e influye en el destino de algunas células madre cancerosas. Aquí analizamos las 34 estructuras de VEGFR2 TK disponibles en la base de datos PDB. De ellas, un complejo ... -
A morphospace for synthetic organs and organoids: the possible and the actual.
(Oxford University Press, 2016)Efforts in evolutionary developmental biology have shed light on how organs are developed and why evolution has selected some structures instead of others. These advances in the understanding of organogenesis along with ... -
A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes
(Nature Research, 2019-12)Translation is a fundamental step in gene expression that regulates multiple developmental and stress responses. One key step of translation initiation is the association between eIF4E and eIF4G. This process is regulated ... -
Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.
López-Jiménez, Auxiliadora; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Springer, 2013-02-01)
Antecedentes: El uso de las hojas de romero (Rosmarinus officinalis) y sus componentes como fuente de antioxidantes dietéticos y agentes aromatizantes está en continuo crecimiento. El carnosol y el ácido carnósico, dos ... -
Arabidopsis Squalene Epoxidase 3 (SQE3) Complements SQE1 and Is Important for Embryo Development and Bulk Squalene Epoxidase Activity
Laranjeira, Sara; Amorim-Silva, Vitor; Esteban del Valle, Alicia; Arró, Montserrat; Ferrer, Albert; Tavares, Rui M.; Botella-Mesa, Miguel Ángel; Rosado, Abel; Azevedo, Herlânder[et al.] (ScienceDirect, 2015-07-06)
The existence of multigenic families in the mevalonate pathway suggests divergent functional roles for pathway components involved in the biosynthesis of plant sterols. Squalene epoxidases (SQEs) are key components of this ... -
Attenuation of cocaine-induced conditioned locomotion is associated with altered expression of hippocampal glutamate receptors in mice lacking LPA1 receptors.
Blanco-Calvo, Eduardo; Bilbao, Ainhoa; Luque-Rojas, María Jesús; Palomino, Ana; Bermúdez Silva, Francisco Javier; Suárez-Pérez, Juan; Santín-Núñez, Luis Javier; Estivill-Torrús, Guillermo; Gutiérrez-Pérez, Antonia; Campos-Sandoval, José A.; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Lysophosphatidic acid is a phospholipid mediator that modulates neurodevelopment and neurogenesis in the hippocampus through its actions on LPA1 receptors. Emerging evidences support LPA1 as a mediator of learning and ... -
Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.
Martín-Rufián, Mercedes; Nascimento-Gomes, Renata; Higuero, Ana; Crisma, Amanda R.; Campos-Sandoval, José A.; Gómez-García, María C.; Cardona, Carolina; Cheng, Tzuling; Lobo, Carolina; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Szeliga, Monika; Albrecht, Jan; Curi, Rui; Márquez-Gómez, Javier; Colquhoun, Alison; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (Springer Nature, 2014)
Mitochondrial glutaminase (GA) plays an essential role in cancer cell metabolism, contributing to biosynthesis, bioenergetics, and redox balance. Humans contain several GA isozymes encoded by the GLS and GLS2 genes, but ... -
Can a minimal replicating construct be identified as the embodiment of cancer?
Solé, Ricard V.; Valverde, Sergi; Rodríguez-Caso, Carlos Francisco; Sardanyés, Josep (Wiley, 2014-04)
Genomic instability is a hallmark of cancer. Cancer cells that exhibit abnormal chromosomes are characteristic of most advanced tumours, despite the potential threat represented by accumulated genetic damage. Carcinogenesis ... -
Can cell mortality determine division of labor in tissue organization?
Rodríguez-Caso, Carlos Francisco (Elsevier, 2014-06)
Tissue organization comes from the emergence of cell cooperation where cell homeostasis and function are per- formed as a trade-off of two excluding proliferative and differentiated cellular states. By introducing function ... -
Causes of B chromosome variant substitution in the grasshopper Eyprepocnemis plorans
Manrique-Poyato, María Inmaculada; Muñoz-Pajares, Antonio Jesús; Loreto, Vilma; López-León, María Dolores; Cabrero-Hurtado, Josefa; Martínez-Camacho, Juan Pedro[et al.] (Springer, 2006)
We have analysed B chromosome frequency for three consecutive years, B transmission rate at population and individual levels, clutch size, egg fertility and embryoYadult viability in a natural population of the ... -
Characterisation of non-coding genetic variation in histamine receptors using AnNCR-SNP.
Rojano, Elena; García-Ranea, Juan Antonio; Perkins, James Richard (Springer, 2016-06-06)
Almost 90 % of disease-associated genetic variants found using genome wide association studies (GWAS) are located in non-coding regions of the genome. Such variants can affect phenotype by altering important regulatory ... -
Cocaine modulates both glutaminase gene expression and glutaminase activity in the brain of cocaine-sensitized mice
Blanco-Calvo, Eduardo; Campos-Sandoval, José Ángel; Palomino, Ana; Luque-Rojas, María Jesús; Bilbao, Ainhoa; Suárez, Juan; Márquez-Gómez, Javier; Rodriguez-de-Fonseca, Fernando[et al.] (Springer, 2012)
Glutaminase is considered the main Glutamate (Glu) producing enzyme. Two isoforms, liver (LGA) and kidney (KGA) type glutaminases have been identified in neurons. The role of both enzymes in psychopharmacological responses ... -
CXCL5 mediates UVB irradiation-induced pain.
(AAAS, 2011-07-06)Many persistent pain states (pain lasting for hours, days, or longer) are poorly treated because of the limitations of existing therapies. Analgesics such as nonsteroidal anti-inflammatory drugs and opioids often provide ... -
Detection and Measurement of Necrosis in Plants.
Minina, Elena A.; Filonova, Lada H; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Daniel, Geoffrey; Bozhkov, Peter V.[et al.] (Humana Press, 2013)
Necrosis plays a fundamental role in plant physiology and pathology. When plants or plant cell cultures are subjected to abiotic stress they initiate rapid cell death with necrotic morphology. Likewise, when plants are ... -
Detection of B chromosomes in interphase hemolymph nuclei from living specimens of the grasshopper Eyprepocnemis plorans
Cabrero-Hurtado, Josefa; Manrique-Poyato, María Inmaculada; Martínez Camacho, Juan Pedro (Karger, 2006)
The two most important evolutionary properties of B chromosomes are their transmission rate (which suggests their selfishness when significantly higher than 0.5) and their net effects on carrier fitness (usually negative ... -
Dimethylfumarate Inhibits Angiogenesis In Vitro and In Vivo: A Possible Role for Its Antipsoriatic Effect?
García-Caballero, Melissa; Mari-Beffa, Manuel; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María (Elsevier, 2011-06-02)
Los ésteres de ácido fumárico (FAE) se han utilizado para el tratamiento oral de la psoriasis durante unos 50 años. Dado que una angiogénesis persistente y mantenida está asociada con varias enfermedades cutáneas, incluida ... -
Ethylene signaling: simple ligand, complex regulation
(ELSEVIER, 2013-10)The hormone ethylene plays numerous roles in plant development. In the last few years the model of ethylene signaling has evolved from an initially largely linear route to a much more complex pathway with multiple feedback ... -
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Cardona, Carolina; Sánchez-Mejías, Elisabeth; Dávila-Cansino, José Carlos; Martín-Rufián, Mercedes; Campos-Sandoval, José Ángel; Vitorica Ferrández, Javier; Alonso-Carrión, Francisco José; Mates-Sánchez, José Manuel; Segura-Checa, Juan Antonio; Norenberg, Michael; Rama Rao, Kakulavarapu; Jayakumar, Arumugan; Gutiérrez-Pérez, Antonia; Márquez-Gómez, Javier[et al.] (Wiley, 2015)
The expression of glutaminase in glial cells has been a controversial issue and matter of debate for many years. Actually, glutaminase is essentially considered as a neuronal marker in brain. Astrocytes are endowed with ... -
Extra spindle poles (Separase) controls anisotropic cell expansion in Norway spruce (Picea abies) embryos independently of its role in anaphase progression.
Moschou, Panagiotis N.; Savenkov, Eugene I; Minina, Elena A.; Fukada, Kazutake; Reza, Salim Hossain; Gutiérrez-Beltrán, Emilio; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Hussey, Patrick J.; Smertenko, Andrei; Bozhkov, Peter V.[et al.] (Wiley-Blackwell, 2016-05-27)
The caspase-related protease separase (EXTRA SPINDLE POLES, ESP) plays a major role in chromatid disjunction and cell expansion in Arabidopsis thaliana. Whether the expansion phenotypes are linked to defects in cell division ... -
Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
(ELSEVIER, 2015-10-22)The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only ...