Listar Biología Molecular y Bioquímica - (BMB) por tipo "info:eu-repo/semantics/preprint"
Mostrando ítems 1-10 de 10
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A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodriguez-Quesada, Ana Maria
; Medina, Miguel Ángel; Martinez-Poveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado-Martín, Belén; Medina, Miguel Ángel (2020-09-22)
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (Elsevier, 2017-04)
The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Involvement of a Myb transcription factor in the regulation of phenylalanine pathway in maritime pine
Craven-Bartle, Blanca; Pascual-Moreno, Maria Belen; Canovas-Ramos, Francisco Miguel; Avila-Saez, Concepcion (2013-12-05)
Wood is traditionally among the most important commercial products because of the high demand that exits for its derivatives. Trees, including conifers, divert large quantities of carbon into the biosynthesis of phenylpropanoids, ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
García-Caballero, Melissa; Blacher, S.; Pauper, J.; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Nöel, Agnes[et al.] (Wiley, 2016)
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce, Ángel Luis; Martinez-Poveda, Beatriz Amparo; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria; Suarez-Marin, Maria Fernanda; Alonso-Carrión, Francisco José; Medina, Miguel Ángel[et al.] (2020-09-23)
Metabolism and its regulation is one of the most complex and difficult topics for students learning biochemistry. A problem-/case-based learning (PBL) approach can be useful to help biochemistry students to fulfill the ... -
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; García-Vilas García, Javier Alejandro (Elsevier, 2016-07)
Purpose: To screen for possible synergistic interactions of epigallocatechin-3-gallate (EGCG) with a selection of 10 anti-angiogenic or anti-tumor compounds on the survival of endothelial and tumor cells. Methods: Human ... -
Sustainability in the management of scientific information
Medina, Miguel Ángel (Springer Nature, 2020-09-25)
The sustainability in the management of scientific information is becoming compromised in this new age of Big Data. Herein, I present and discuss some of the main challenges of this situation in both scientific practice ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ...