Listar Biología Molecular y Bioquímica - (BMB) por tipo "info:eu-repo/semantics/publishedVersion"
Mostrando ítems 1-20 de 110
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A bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Carbonell-Ballesteros, Max; Durán-Nebreda, Salva; Montañez, Raúl; Macía, Javier; Rodríguez-Caso, Carlos Francisco
(Oxfrod University Press, 2014-12-16)
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly ... -
A comparison of RNA-seq and exon arrays for whole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat
(SAGE Publications, 2014-01-28)The past decade has seen an abundance of transcriptional profiling studies of preclinical models of persistent pain, predominantly employing microarray technology. In this study we directly compare exon microarrays to ... -
A course-based undergraduate research experience to illustrate the early stages of the drug discovery process
García-Caballero, Melissa; Moya-García, Aurelio Ángel; Torres-Vargas, José Antonio; García-Ponce, Ángel Luis; Rodríguez-Quesada, Ana María (Wiley, 2022-07-12)
We have implemented at the University of Málaga (Spain) a new course-based undergraduate research experience (CURE) to involve undergraduate students of Science in a real-world scientific problem. Within the topic “Let's ... -
A Proteomic Study of the Bioactivity of Annona muricata Leaf Extracts in HT-1080 Fibrosarcoma Cells.
Marrero Capitán, Ana Dácil; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Cárdenas, Casimiro (MDPI, 2023-07-27)
Graviola (Annona muricata) is a tropical plant with many traditional ethnobotanic uses and pharmacologic applications. A metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves recently allowed ... -
A revised view on the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Hirel, Bertrand; Cantón, Francisco R.; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2022-02)
Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
Altered insulin secretion dynamics relate to oxidative stress and inflammasome activation in children with obesity and insulin resistance
(Springer Nature, 2023-08-20)Background: Insulin resistance (IR) is considered the main driver of obesity related metabolic complications, and is related to oxidative stress and inflammation, which in turn promote each other. There is currently no ... -
AMMO-Prot: Amine system project 3D-model finder
Navas-Delgado, Ismael; Pino-Ángeles, Almudena; Montañez, Raúl; Moya-García, Aurelio Ángel; Urdiales-Ruiz, José Luis; Sánchez-Jiménez, Francisca María; Aldana-Montes, José Francisco[et al.] (Springer Nature, 2008-04)
Background: Amines are biogenic amino acid derivatives, which play pleiotropic and very important yet complex roles in animal physiology. For many other relevant biomolecules, biochemical and molecular data are being ... -
Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex
Ortigosa, Francisco; Lobato-Fernández, César; Shikano, Hitomi; Ávila-Sáez, Concepción; Taira, Shu; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2021-11-01)
Ammonium is a prominent source of inorganic nitrogen for plant nutrition, but excessive amounts can be toxic for many species. However, most conifers are tolerant to ammonium, a relevant physiological feature of this ancient ... -
An improved de novo assembling and polishing of Solea senegalensis transcriptome shed light on retinoic acid signalling in larvae
(Scientific Reports (Springer Nature), 2020)Senegalese sole is an economically important species in aquaculture and a model to decipher the severe transformations occurring during flatfish metamorphosis. A robust sole transcriptome was envisaged from a total of 96 ... -
An updated nomenclature for plant ribosomal protein genes
(American Society of Plant Biologists (ASPB), 2023-02-20)Proponemos a la comunidad que trabaja con plantas una nueva nomenclatura universal y homogénea para las proteínas ribosomales (y sus parálogos) -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Antiangiogenic potential of an olive oil extract: insights from a proteomic study
Marrero Capitán, Ana Dácil; Cárdenas García, Casimiro; Castilla, Laura; Ortega Vidal, Juan; Rodríguez-Quesada, Ana María; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ACS, 2024)
Extra virgin olive oil (EVOO), a staple of the Mediterranean diet, is rich in phenolic compounds recognized for their potent bioactive effects, including anticancer and anti-inflammatory properties. However, its effects ... -
Antioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs
Casas Arrojo, Virginia; Arrojo-Agudo, María Ángeles; Cárdenas García, Casimiro; Carrillo Fernández, Paloma; Pérez Manríquez, Claudia; Martínez-Manzanares, Eduardo; Abdala-Díaz, Roberto Teófilo[et al.] (IOAP-MDPI, 2022-11-10)
The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy ... -
Autophagy and metacaspase determine the mode of cell death in plants
Minina, Elena A; Filonova, Lada H; Fukada, Kazutake; Savenkov, Eugene I; Gogvadze, Vladimir; Clapham, David; Sánchez-Vera, Victoria; Suárez-Marín, María Fernanda; Zhivotovsky, Boris; Daniel, Geoffrey; Smertenko, Andrei; Bozhkov, Peter V[et al.] (Rockefeller University Press, 2013-12-16)
Although animals eliminate apoptotic cells using macrophages, plants use cell corpses throughout development and disassemble cells in a cell- autonomous manner by vacuolar cell death. During vacuolar cell death, lytic ... -
Autophagy is required for gamete differentiation in the moss Physcomitrella patens.
(Autophagy / Landes Biosciences, 2017-09-25)Autophagy, a major catabolic process in eukaryotes, was initially related to cell tolerance to nutrient depletion. In plants autophagy has also been widely related to tolerance to biotic and abiotic stresses (through the ... -
Autophagy is required for strawberry fruit ripening
Sánchez-Sevilla, José F; Botella-Mesa, Miguel Ángel; Valpuesta-Fernández, Victoriano; Sánchez-Vera, Victoria (Frontiers Media SA, 2021-08-27)
Autophagy is a catabolic and recycling pathway that maintains cellular homeostasis under normal growth and stress conditions. Two major types of autophagy, microautophagy and macroautophagy, have been described in plants. ... -
Autophagy mediates caloric restriction-induced lifespan extension in Arabidopsis.
Minina, Alyona; Sánchez-Vera, Victoria; Moschou, Panagiotis N.; Suárez-Marín, María Fernanda; Sundberg, Eva; Weih, Martin; Bozhkov, Peter V.[et al.] (Aging Cell/Blackwell publishing Ltd/Anatomical Society of Great Britain and Ireland, 2013-01-17)
Caloric restriction (CR) extends lifespan in various heterotrophic organisms ranging from yeasts to mammals, but whether a similar phenomenon occurs in plants remains unknown. Plants are autotrophs and use their photosynthetic ... -
Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination
(Oxford University Press, 2013-07)Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the ... -
Biomarker potential of repetitive-element transcriptome in lung cancer
Claros-Díaz, Manuel Gonzalo; Arroyo, Macarena; Bautista-Moreno, Rocío; Larrosa-Jiménez, Rafael; Cobo, Manuel Ángel (PeerJ, 2019)
Since repetitive elements (REs) account for nearly 53% of the human genome, profiling its transcription after an oncogenic change might help in the search for new biomarkers. Lung cancer was selected as target since it is ...