BMB - Artículos
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Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María
; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)
Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
Monterde, Beatriz; Rojano Rivera, María Elena; Córdoba Caballero, Jose; Seoane Zonjic, Pedro; Perkins, James Richard; Medina-Torres, Miguel Ángel; García-Ranea, Juan Antonio[et al.] (Elsevier, 2023)
Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)
The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; Sánchez López, José María; Trigal Martínez, Mónica; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2023-05-15)
The role played by a sustained angiogenesis in cancer and other diseases stimulates the interest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence that 1,8- dihydroxy-9,10-anthraquinone ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)
The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
(Frontiers Media, 2022-04-25)The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
OliveAtlas: a gene expression atlas tool for olea europaea
Bullones, Amanda; Castro, Antonio Jesús; Lima-Cabello, Elena; Alché, Juan de Dios; Luque, Francisco; Claros-Díaz, Manuel Gonzalo; Fernández-Pozo, Noé[et al.] (MDPI, 2023-03-10)
The olive (Olea europaea L.) is an ancient crop of great importance in the Mediterranean basin due to the production of olive oil and table olives, which are important sources of fat and have benefits for human health. ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
Carrillo, P; Bernal, M; Téllez Quijorna, Clara; Marrero, A.D; Vidal-Valenzuela, Isabel; Castilla, L; Caro, C; Domínguez, A; García-Martín, M.L; Quesada, A.R.; Medina, M.A; Martínez-Póveda, Beatriz Amparo[et al.] (Elsevier, 2022-12-14)
Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ... -
Emerging insights into nitrogen assimilation in gymnosperms
Valderrama-Martín, José Miguel; Ortigosa Peña, Francisco; Ruiz-Canton, Francisco Javier; Ávila-Sáez, Concepción; Cañas-Pendón, Rafael Antonio; Cánovas-Ramos, Francisco Miguel[et al.] (Springer, 2023)
Gymnosperms are a heterogeneous and ancient group of seed plants that includes conifers, ginkgos, cycads and gnetophytes. Molecular studies on extant gymnosperms have been constrained by some discouraging features for ... -
Pine has two glutamine synthetase paralogs, GS1b.1 and GS1b.2, exhibiting distinct biochemical properties
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Aledo-Ramos, Juan Carlos; Ávila-Sáez, Concepción; Cánovas-Ramos, Francisco Miguel; Cañas-Pendón, Rafael Antonio[et al.] (Wiley, 2023)
The enzyme glutamine synthetase (EC 6.3.1.2) is mainly responsible for the incorporation of inorganic nitrogen into organic molecules in plants. In the present work, a pine (Pinus pinaster) GS1 (PpGS1b.2) gene was identified, ... -
Construction of miRNA–mRNA networks for the identification of lung cancer biomarkers in liquid biopsies
Espinosa García, Elena María; Arroyo Varela, Macarena; Larrosa-Jiménez, Rafael; Gomez‑Maldonado, Josefa; Cobo Dols, Manuel Ángel; Claros-Díaz, Manuel Gonzalo; Bautista-Moreno, Rocío[et al.] (Springer Nature, 2022-10-12)
Lung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis ... -
Dissecting the impact of environment, season and genotype on blackcurrant fruit quality traits
Pott, Delphine M.; Durán-Soria, Sara; Allwood, J. William; Pont, Simon; Gordon, Sandra. L; Jennings, Nikki; Austin, Ceri; Stewart, Derek; Brennan, Rex M.; Masny, Agnieszka; Sønsteby, Anita; Krüger, Erika; Jarret, Dorota; Vallarino Castro, José G.; Usadel, Björn; Osorio-Algar, Sonia[et al.] (ELSEVIER, 2022-09-21)
This work aims to determine the effect of genotype x environment (GxE) interaction that influence blackcurrant (Ribes nigrum) fruit quality. We applied metabolomics-driven analysis on fruits from four cultivars grown in ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-García, Aurelio Ángel; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Development and Validation of a Multilingual Lexicon as a Key Tool for the Sensory Analyses and Consumer Tests of Blueberry and Raspberry Fruit
Lippi, Nico; Senger, Elisa; Karhu, Saila; Mezzetti, Bruno; Cianciabella, Marta; Ayvaz Sönmez, Duygu; Fidelis, Marina; Gatti, Edoardo; Höfer, Monika; Ebru Kafkas, Nesibe; Mazzoni, Luca; McCallum, Susan; Olbricht, Klaus; Orsucci, Saverio; Osorio-Algar, Sonia; Pinczinger, Dora; Predieri, Stefano; Rokka, Susanna; Sánchez-Sevilla, José Federico; Savini, Gianluca; Soria, Carmen; Usadel, Björn; Zucchi, Paolo; Chiara, Medoro[et al.] (IOAP-MDPI, 2023-01-28)
A comprehensive lexicon is a necessary communication tool between the panel leader and panelists to describe each sensory stimulus potentially evoked by a product. In the current scientific breeding and trading scenario, ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
de los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Proteome-Wide Structural Computations Provide Insights into Empirical Amino Acid Substitution Matrices
Aledo, Pablo; Aledo-Ramos, Juan Carlos (IOAP-MDPI, 2023-01-02)
The relative contribution of mutation and selection to the amino acid substitution rates observed in empirical matrices is unclear. Herein, we present a neutral continuous fitness-stability model, inspired by the Arrhenius ... -
Antioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs
Casas Arrojo, Virginia; Arrojo-Agudo, María Ángeles; Cárdenas García, Casimiro; Carrillo Fernández, Paloma; Pérez Manríquez, Claudia; Martinez-Manzanares, Eduardo; Abdala-Díaz, Roberto Teófilo[et al.] (IOAP-MDPI, 2022-11-10)
The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy ...