Listar BMB - Artículos por autor "Rodríguez-Quesada, Ana María"
Mostrando ítems 1-20 de 20
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A course-based undergraduate research experience to illustrate the early stages of the drug discovery process
García-Caballero, Melissa; Moya-García, Aurelio Ángel; Torres-Vargas, José Antonio; García-Ponce, Ángel Luis; Rodríguez-Quesada, Ana María (Wiley, 2022-07-12)We have implemented at the University of Málaga (Spain) a new course-based undergraduate research experience (CURE) to involve undergraduate students of Science in a real-world scientific problem. Within the topic “Let's ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Angioprevention of Urologic Cancers by Plant-Derived Foods.
García-Caballero, Melissa; Torres-Vargas, José Antonio; Marrero Capitán, Ana Dácil; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2022-01-21)The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney ... -
Anti-angiogenic effects of oleacein and oleocanthal: New bioactivities of compounds from Extra Virgin Olive Oil
Marrero Capitán, Ana Dácil; Ortega Vidal, Juan; Salido, Sofía; Castilla, Laura; Vidal-Valenzuela, Isabel; Rodríguez-Quesada, Ana María; Altarejos, Joaquín; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (Elsevier, 2023-09)Phenolic compounds play a key role in the health benefits of Extra Virgin Olive Oil (EVOO). Among these molecules, the focus has been recently put on (−)-oleocanthal and (−)-oleacein, for which anti-cancer and angiogenesis-related ... -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
García-Ponce, Ángel Luis; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Blanco-López, Ángel; Rodríguez-Quesada, Ana María[et al.] (ACS Publications, 2021)Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
Characterization of the activity and the mechanism of action of a new toluquinol derivative with improved potential as an antiangiogenic drug.
Torres-Vargas, José Antonio; Cheng-Sánchez, Iván; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Sarabia-García, Francisco Ramón; García-Caballero, Melissa; Rodríguez-Quesada, Ana María[et al.] (Elsevier, 2022-09-30)The inhibition of sustained angiogenesis is an attractive approach for the treatment of cancer, blindness and other angiogenesis-dependent diseases. Encouraged by our previous finding that toluquinol, a methyl hydroquinone ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero Capitán, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (2020-09-22)The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (Royal Society of Chemistry, 2018)Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Danthron, an Anthraquinone Isolated from a Marine Fungus, Is a New Inhibitor of Angiogenesis Exhibiting Interesting Antitumor and Antioxidant Properties
Vidal-Valenzuela, Isabel; Torres-Vargas, José Antonio; Sánchez López, José María; Trigal Martínez, Mónica; García-Caballero, Melissa; Medina-Torres, Miguel Ángel; Rodríguez-Quesada, Ana María[et al.] (MDPI, 2023-05-15)The role played by a sustained angiogenesis in cancer and other diseases stimulates the interest in the search for new antiangiogenic drugs. In this manuscript, we provide evidence that 1,8- dihydroxy-9,10-anthraquinone ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Carrillo Fernández, Paloma; Rodríguez-Quesada, Ana María; López-Romero, Juan Manuel; Sarabia-García, Francisco Ramón[et al.] (2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Mari-Beffa, Manuel (2018-10-19)Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-04)The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
Cárdenas García, Casimiro; Torres-Vargas, José Antonio; Cárdenas Valdivia, Abel; Jurado, Nuria; Rodríguez-Quesada, Ana María; García-Caballero, Melissa; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ELSEVIER, 2021-11)The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ... -
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
García-Caballero, Melissa; Blacher, S.; Pauper, J.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Noël, Agnès[et al.] (Wiley, 2016)BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce, Ángel Luis; Martínez-Póveda, Beatriz Amparo; Blanco-López, Ángel; Rodríguez-Quesada, Ana María; Suárez-Marín, María Fernanda; Alonso-Carrión, Francisco José; Medina-Torres, Miguel Ángel[et al.] (2020-09-23)Metabolism and its regulation is one of the most complex and difficult topics for students learning biochemistry. A problem-/case-based learning (PBL) approach can be useful to help biochemistry students to fulfill the ... -
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; García-Vilas García, Javier Alejandro (Elsevier, 2016-07)Purpose: To screen for possible synergistic interactions of epigallocatechin-3-gallate (EGCG) with a selection of 10 anti-angiogenic or anti-tumor compounds on the survival of endothelial and tumor cells. Methods: Human ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martínez-Póveda, Beatriz Amparo; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-01)The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer
Carrillo Fernández, Paloma; Bernal Muñoz, Manuel; Téllez Quijorna, Clara; Marrero Capitán, Ana Dácil; Vidal-Valenzuela, Isabel; Castilla, Laura; Caro Salazar, Carlos; Domínguez Moreno, Alejandro; García-Martín, María Luisa; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (Elsevier, 2022-12-14)Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration ... -
Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles
Medina-Torres, Miguel Ángel; García-Ponce, Ángel Luis; Blanco-López, Ángel; Rodríguez-Quesada, Ana María; Urdiales-Ruiz, José Luis; Fajardo-Paredes, Ignacio José; Suárez-Marín, María Fernanda; Alonso-Carrión, Francisco José[et al.] (ACS, 2022-05-25)Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on ...