Listar BMB - Artículos por título
Mostrando ítems 24-43 de 56
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Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodríguez-Quesada, Ana María
; Medina-Torres, Miguel Ángel; Marí-Beffa, Manuel (2018-10-19)
Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
Martín-Pizarro, Carmen; Triviño, Juan Carlos; Pose-Padilla, David (bioRxiv, 2018-06-20)
The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
Martín-Pizarro, Carmen; Triviño, Juan Carlos; Pose-Padilla, David (Oxford University Press, 2019-01)
The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José F; Vallarino Castro, José G.; Osorio-Algar, Sonia; Bombarely, Aureliano; Pose-Padilla, David; Merchante-Berg, Catharina; Botella-Mesa, Miguel Ángel; Amaya Saavedra, Iraida; Valpuesta-Fernández, Victoriano[et al.] (Springer Nature, 2017-10-23)
RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
Martín-Pizarro, Carmen; Pose-Padilla, David (Frontiers, 2018-09-25)
Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-04)
The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
Monterde, Beatriz; Rojano Rivera, María Elena; Córdoba Caballero, José; Seoane Zonjic, Pedro; Perkins, James Richard; Medina-Torres, Miguel Ángel; García-Ranea, Juan Antonio[et al.] (Elsevier, 2023)
Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-García, Aurelio Ángel; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
Mathematical modeling of cancer metabolism
Medina-Torres, Miguel Ángel (2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
De los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sánchez, José Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina-Torres, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodríguez-Quesada, Ana María (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Modulating Vascular Lymphatic Growth in Disease: Current and Potential Pharmacological Approaches for Prevention and Treatment
(Frontiers Media, 2022-04-25)The lymphatic system is part of the circulatory system and it is indispensable for life. In physiological conditions, the main functions assigned to the lymphatic system are the maintenance of the interstitial fluid ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
Cárdenas García, Casimiro; Torres-Vargas, José Antonio; Cárdenas Valdivia, Abel; Jurado, Nuria; Rodríguez-Quesada, Ana María; García-Caballero, Melissa; Martínez-Póveda, Beatriz Amparo; Medina-Torres, Miguel Ángel[et al.] (ELSEVIER, 2021-11)
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ... -
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
García-Caballero, Melissa; Blacher, S.; Pauper, J.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Nöel, Agnes[et al.] (Wiley, 2016)
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
OliveAtlas: a gene expression atlas tool for olea europaea
Bullones, Amanda; Castro, Antonio Jesús; Lima-Cabello, Elena; Alché, Juan de Dios; Luque, Francisco; Claros-Díaz, Manuel Gonzalo; Fernández-Pozo, Noé[et al.] (MDPI, 2023-03-10)
The olive (Olea europaea L.) is an ancient crop of great importance in the Mediterranean basin due to the production of olive oil and table olives, which are important sources of fat and have benefits for human health. ...