Listar BMB - Artículos por título
Mostrando ítems 62-81 de 148
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Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José F; Vallarino Castro, José G.; Osorio-Algar, Sonia
; Bombarely, Aureliano; Posé-Padilla, David; Merchante-Berg, Catharina; Botella-Mesa, Miguel Ángel; Amaya Saavedra, Iraida; Valpuesta-Fernández, Victoriano[et al.] (Springer Nature, 2017-10-23)
RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
(ELSEVIER, 2015-10-22)The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only ... -
Gene3D: a domain-based resource for comparative genomics, functional annotation and protein network analysis
(Oxford University Press, 2012-01)Gene3D http://gene3d.biochem.ucl.ac.uk is a comprehensive database of protein domain assignments for sequences from the major sequence databases. Domains are directly mapped from structures in the CATH database or predicted ... -
Generation and analysis of ESTs from strawberry (Fragaria xananassa) fruits and evaluation of their utility in genetic and molecular studies
Bombarely, Aureliano; Merchante-Berg, Catharina; Csukasi, Fabiana; Cruz-Rus, Eduardo; Caballero, José L.; Medina-Escobar, Nieves; Blanco-Portales, Rosario; Botella, Miguel A.; Muñoz-Blanco, Juan; Sánchez-Sevilla, José F; Valpuesta-Fernández, Victoriano[et al.] (BMC, 2010-09-17)
Cultivated strawberry is a octoploid species whose fruit is highly appreciated due to its organoleptic properties and health benefits. However, information about the role played by different hormones on these processes ... -
Genetic and genome-wide transcriptomic analyses identify co- regulation of oxidative response and hormone transcript abundance with vitamin C content in tomato fruit.
Lima-Silva, Viviana; Rosado, Abel; Amorim-Silva, Vitor; Muñoz-Mérida, Antonio; Pons, Clara; Bombarely, Aureliano; Trelles, Oswaldo; Fernández Muñoz, Rafael; Granell, Antonio; Valpuesta-Fernández, Victoriano; Botella-Mesa, Miguel Ángel[et al.] (BioMed Central, 2012-05-14)
L-ascorbic acid (AsA; vitamin C) is essential for all living plants where it functions as the main hydrosoluble antioxidant. It has diverse roles in the regulation of plant cell growth and expansion, photosynthesis, and ... -
Genetic diversity of strawberry germplasm using metabolomic biomarkers.
Vallarino, José G.; De Abreu e Lima, Francisco; Soria, Carmen; Tong, Hao; Pott, Delphine M.; Willmitzer, Lothar; Fernie, Alisdair R.; Nikoloski, Zoran; Osorio-Algar, Sonia[et al.] (Springer Nature, 2018-09-26)
High-throughput metabolomics technologies can provide the quantification of metabolites levels across various biological processes in different tissues, organs and species, allowing the identification of genes underpinning ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
Martín-Pizarro, Carmen; Posé-Padilla, David (Frontiers, 2018-09-25)
Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
GLS and GLS2 Glutaminase Isoenzymes in the Antioxidant System of Cancer Cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Alonso-Carrión, Francisco José; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel (MDPI, 2024-06-20)
A pathway frequently altered in cancer is glutaminolysis, whereby glutaminase (GA) catalyzes the main step as follows: the deamidation of glutamine to form glutamate and ammonium. There are two types of GA isozymes, named ... -
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Peñalver Alonso, Ana; Campos-Sandoval, José Ángel; Blanco-Calvo, Eduardo; Cardona Ramírez, Carolina; Castilla, Laura; Martín-Rufián, Mercedes; Estivill-Torrús, Guillermo; Sánchez-Varo, Raquel María; Alonso-Carrión, Francisco José; Pérez-Hernández, Mercedes; Colado, María Isabel; Gutiérrez-Pérez, Antonia; Rodriguez-de-Fonseca, Fernando; Márquez-Gómez, Javier[et al.] (Frontiers, 2017-09-05)
Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor ... -
Glutaminase isoforms expression switches microRNA levels and oxidative status in glioblastoma cells.
De los Santos-Jiménez, Juan; Campos-Sandoval, José Ángel; Márquez-Torres, Clara; Urbano-Polo, Nieves; Brøndegaard, David; Martín-Rufián, Mercedes; Lobo, Carolina; Peñalver Alonso, Ana; Gómez García, María del Carmen; Martín-Campos, Janet; Cardona Ramírez, Carolina; Castilla, Laura; Da-Costa-Souza, Felipe; Cheng, Tzuling; Segura-Checa, Juan Antonio; Alonso-Carrión, Francisco José; Curi, Rui; Colquhoun, Alison; DeBerardinis, Ralph J; Márquez-Gómez, Javier; Mates-Sánchez, José Manuel[et al.] (BMC, 2021-02-20)
Glutaminase isoenzymes GLS and GLS2 play apparently opposing roles in cancer: GLS acts as an oncoprotein, while GLS2 (GAB isoform) has context specific tumour suppressive activity. Some microRNAs (miRNAs) have been implicated ... -
High Levels of Variation Within Gene Sequences of Olea europaea L.
Cultrera, Nicoló M.; Sarri, Vania; Lucentini, Livia; Ceccarelli, Marilena; Alagna, Fiammetta; Mariotti, Roberto; Mousavi, Soraya; Guerrero-Ruiz, Consolación María; Baldoni, Luciana[et al.] (Frontiers Media, 2019-01-08)
Gene sequence variation in cultivated olive (Olea europaea L. subsp. europaea var. europaea), the most important oil tree crop of the Mediterranean basin, has been poorly evaluated up to now. A deep sequence analysis of ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
García-Vilas, Javier A.; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel (Elsevier, 2017-04)
The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus
Ojeda-Pérez, Betsaida; Campos-Sandoval, José Ángel; García-Bonilla, María; Cárdenas García, Casimiro; Páez-González, Patricia; Jiménez-Lara, Antonio Jesús[et al.] (BMC, 2021)
Periventricular extracellular oedema, myelin damage, inflammation, and glial reactions are common neuropathological events that occur in the brain in congenital hydrocephalus. The periventricular white matter is the most ... -
Identification of quantitative trait loci and candidate genes for primary metabolite content in strawberry fruit
Pott, DM; Cruz-Rus, E; Miranda, L; Medina-Minguez, JJ; Valpuesta-Fernández, Victoriano; Fernie, AR; Sanchez-Sevilla, JF; Osorio-Algar, Sonia; Amaya, I[et al.] (2019)
Improvement of nutritional and organoleptic quality of fruits is a key goal in current strawberry breeding programs. The ratio of sugars to acids is a determinant factor contributing to fruit liking, although different ... -
Inhibition of Endothelial Inflammatory Response by HT-C6, a Hydroxytyrosol Alkyl Ether Derivative.
Marrero Capitán, Ana Dácil; Castilla, Laura; Bernal, Manuel; Manrique-Poyato, María Inmaculada; Posligua-García, Joel; Moya-Utrera, Federico; Porras Alcalá, Cristina; Espartero Sánchez, José Luis; Sarabia-García, Francisco Ramón; Rodríguez-Quesada, Ana María; Medina-Torres, Miguel Ángel; Martínez-Póveda, Beatriz Amparo[et al.] (MDPI, 2023-07-28)
Hydroxytyrosol (HT) is a bioactive phenolic compound naturally present in olives and extra virgin olive oil (EVOO) which is described as an antioxidant, antitumoral and antiangiogenic molecule. Previous studies of ... -
Insights into ROS‐dependent signalling underlying transcriptomic plant responses to the herbicide 2,4‐D
Romero Puertas, María C.; Peláez-Vico, María Ángeles; Pazmiño, Diana M.; Rodríguez Serrano, María; Terrón Camero, Laura; Bautista-Moreno, Rocío; Gómez-Cadenas, Aurelio; Claros-Díaz, Manuel Gonzalo; León, José; Sandalio, Luisa M.[et al.] (Plant Cell & Environment, 2022)
The synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D) functions as an agronomic weed control herbicide. High concentrations of 2,4-D induce plant growth defects, particularly leaf epinasty and stem curvature. Although ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
Monterde, Beatriz; Rojano Rivera, María Elena; Córdoba Caballero, José; Seoane Zonjic, Pedro; Perkins, James Richard; Medina-Torres, Miguel Ángel; García-Ranea, Juan Antonio[et al.] (Elsevier, 2023)
Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
Isolation, characterization, and localization of AgaSGNH cDNA: a new SGNH-motif plant hydrolase specific to Agave americana L. leaf epidermis.
Reina Martín, José Juan; Guerrero-Ruiz, Consolación María; Heredia-Bayona, Antonio (Oxford University Press, 2007-07-03)
GDSL and SGNH hydrolases are lipases involved in a wide range of functions, behaving in many cases as bifunctional enzymes. In this work, the isolation and characterization of AgaSGNH, a cDNA encoding a member of the ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
Adeyelu, Tolulope; Bordin, Nicola; Waman, Vaishali P.; Sadlej, Marta; Sillitoe, Ian; Moya-García, Aurelio Ángel; Orengo, Christine A.[et al.] (IOAP-MDPI, 2023-02-02)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ...