Listar BMB - Artículos por título
Mostrando ítems 24-41 de 41
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Mathematical modeling of cancer metabolism
Medina, Miguel Ángel
(2018-10-19)
Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
de los Santos-Jiménez, Juan; Rosales, Tracy; Ko, Bookyung; Campos-Sandoval, Jose Angel; Alonso, Francisco J.; Márquez-Gómez, Javier; DeBerardinis, Ralph J; Mates-Sanchez, Jose Manuel[et al.] (IOAP-MDPI, 2023-01-15)
Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming is a Hallmark of Metabolism Itself
Medina, Miguel Ángel (2020-09-23)
The reprogramming of metabolism has been identified as one of the hallmarks of cancer. It is becoming more and more frequent to connect other diseases with metabolic reprogramming. This article aims to argue that metabolic ... -
Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target
Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Ocaña Farfán, María del Carmen; Rodriguez-Quesada, Ana Maria (2018-10-19)
Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed ... -
Network-Based Methods for Approaching Human Pathologies from a Phenotypic Point of View
(IOAP-MPDI, 2022-06-17)Network and systemic approaches to studying human pathologies are helping us to gain insight into the molecular mechanisms of and potential therapeutic interventions for human diseases, especially for complex diseases where ... -
Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
Cárdenas, Casemiro; Torres-Vargas, José Antonio; Cárdenas Valdivia, Abel; Jurado, Nuria; Rodriguez-Quesada, Ana Maria; García-Caballero, Melissa; Martinez-Poveda, Beatriz Amparo; Medina Torres, Miguel Ángel[et al.] (ELSEVIER, 2021-11)
The tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. ... -
Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway
García-Caballero, Melissa; Blacher, S.; Pauper, J.; Quesada, Ana R.; Medina, Miguel Ángel; Nöel, Agnes[et al.] (Wiley, 2016)
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory ... -
A problem-/case-based learning approach as an useful tool for studying glycogen metabolism and its regulation
García-Ponce, Ángel Luis; Martinez-Poveda, Beatriz Amparo; Blanco-Lopez, Angel; Quesada, Ana R.; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose; Medina, Miguel Ángel[et al.] (2020-09-23)
Metabolism and its regulation is one of the most complex and difficult topics for students learning biochemistry. A problem-/case-based learning (PBL) approach can be useful to help biochemistry students to fulfill the ... -
Profiling the Influence of Gene Variants Related to Folate-Mediated One-Carbon Metabolism on the Outcome of In Vitro Fertilization (IVF) with Donor Oocytes in Recipients Receiving Folic Acid Fortification
Reyes Palomares, Arturo Lazaro; Ruiz-Galdon, Maximiliano; Liu, Kui; Reyes-Engel, Armando; Rodriguez-Wallberg, Kenny A. (IOAP-MPDI, 2022-09-25)
Nutritional status and gene polymorphisms of one-carbon metabolism confer a well-known interaction that in pregnant women may affect embryo viability and the health of the newborn. Folate metabolism directly impacts ... -
Proteome-Wide Structural Computations Provide Insights into Empirical Amino Acid Substitution Matrices
Aledo, Pablo; Aledo-Ramos, Juan Carlos (IOAP-MDPI, 2023-01-02)
The relative contribution of mutation and selection to the amino acid substitution rates observed in empirical matrices is unclear. Herein, we present a neutral continuous fitness-stability model, inspired by the Arrhenius ... -
Screening of Synergistic Interactions of Epigallocatechin-3-gallate with Antiangiogenic and Antitumor Compounds
Quesada, Ana R.; Medina, Miguel Ángel; García-Vilas García, Javier Alejandro (Elsevier, 2016-07)
Purpose: To screen for possible synergistic interactions of epigallocatechin-3-gallate (EGCG) with a selection of 10 anti-angiogenic or anti-tumor compounds on the survival of endothelial and tumor cells. Methods: Human ... -
Secretory Profile of Adipose-Tissue-Derived Mesenchymal Stem Cells from Cats with Calicivirus-Positive Severe Chronic Gingivostomatitis
Villatoro, Antonio J.; Martín Astorga, María del Carmen; Alcoholado Cueto, Cristina; Kazantseva, Liliya; Cardenas, Casimiro; Fariñas, Fernando; Becerra-Ratia, Jose; Visser, Rick[et al.] (IOAP-MPDI, 2022-05-25)
The feline calicivirus (FCV) causes infections in cats all over the world and seems to be related to a broad variety of clinical presentations, such as feline chronic gingivostomatitis (FCGS), a severe oral pathology in ... -
Sustainability in the management of scientific information
Medina, Miguel Ángel (Springer Nature, 2020-09-25)
The sustainability in the management of scientific information is becoming compromised in this new age of Big Data. Herein, I present and discuss some of the main challenges of this situation in both scientific practice ... -
Synthesis, characterization and biological evaluation of octyltrimethylammonium tetrathiotungstate
Vega-Granados, Karla; Cruz-Reyes, Juan; Horta-marrón, José F.; Mari-Beffa, Manuel; Díaz-Rubio, Laura; Córdova-Guerrero, Iván; Chávez-Velasco, Daniel; Ocaña, M. Carmen; Medina, Miguel Ángel; Romero-Sánchez, Lilian B.[et al.] (Springer Nature, 2021)
Octyltrimethylammonium tetrathiotungstate salt (ATT-C8) was synthesized and its ability to chelate copper was evaluated. The biological and toxic aspects were evaluated by in vitro and in vivo assays, using bovine aorta ... -
The NAC transcription factor FaRIF controls fruit ripening in strawberry
Martín-Pizarro, Carmen; Vallarino, José G.; Osorio-Algar, Sonia; Meco, Victoriano; Urrutia, María; Pillet, Jeremy; Casañal, Ana; Merchante, Catharina; Amaya, Iraida; Willmitzer, Lothar; Fernie, Alisdair R; Giovannoni, James J; Botella-Mesa, Miguel Angel; Valpuesta-Fernandez, Victoriano; Posé, David[et al.] (Oxford University Press, 2021-02-24)
In contrast to climacteric fruits such as tomato, the knowledge on key regulatory genes controlling the ripening of straw- berry, a nonclimacteric fruit, is still limited. NAC transcription factors (TFs) mediate different ... -
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
García-Vilas, Javier A.; Pino-Ángeles, Almudena; Martinez-Poveda, Beatriz Amparo; Quesada, Ana R.; Medina, Miguel Ángel (Elsevier, 2017-01)
The natural bioactive compound damnacanthal inhibits several tyrosine kinases. Herein, we show that -in fact- damancanthal is a multi kinase inhibitor. A docking and molecular dynamics simulation approach allows getting ... -
Transcriptome Analysis and Intraspecific Variation in Spanish Fir (Abies pinsapo Boiss.)
Ortigosa Peña, Francisco; Avila-Saez, Concepcion; Rubio-Valverde, Lourdes; Álvarez-Garrido, Lucía; Carreira de la Fuente, José Antonio; Cañas-Pendon, Rafael Antonio; Canovas-Ramos, Francisco Miguel[et al.] (IOAP-MPDI, 2022-08-19)
Spanish fir (Abies pinsapo Boiss.) is an endemic, endangered tree that has been scarcely investigated at the molecular level. In this work, the transcriptome of Spanish fir was assembled, providing a large catalog of ... -
Turning around Cycles: An Approach Based on Selected Problems/Cases to Stimulate Collaborative Learning about Krebs and His Four Metabolic Cycles
Medina, Miguel Ángel; García-Ponce, Ángel Luis; Blanco-Lopez, Angel; Quesada, Ana R.; Urdiales-Ruiz, Jose Luis; Fajardo-Paredes, Ignacio José; Suarez-Marin, Maria Fernanda; Alonso-Carrion, Francisco Jose[et al.] (ACS, 2022-05-25)
Metabolism is a challenging subject for bioscience students due to the intrinsic complexity of the metabolic network, as well as that of the overlapping mechanisms of metabolic regulation. Collaborative learning based on ...