Listar BMB - Artículos por título
Mostrando ítems 28-47 de 76
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Emerging insights into nitrogen assimilation in gymnosperms
(Springer, 2023)Gymnosperms are a heterogeneous and ancient group of seed plants that includes conifers, ginkgos, cycads and gnetophytes. Molecular studies on extant gymnosperms have been constrained by some discouraging features for ... -
Ethylene is involved in strawberry fruit ripening in an organ-specific manner
(Oxford University Press [University Publisher], Society for Experimental Biology [Society Publisher], 2013-11)The fruit of the strawberry F ananassa has traditionally been classified as non-climacteric because its ripening process is not governed by ethylene. However, previous studies have reported the timely endogenous production ... -
Ethylene signaling: simple ligand, complex regulation
(ELSEVIER, 2013-10)The hormone ethylene plays numerous roles in plant development. In the last few years the model of ethylene signaling has evolved from an initially largely linear route to a much more complex pathway with multiple feedback ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
(2018-10-19)New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
(2018-10-19)Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(bioRxiv, 2018-06-20)The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(Oxford University Press, 2019-01)The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
(Springer Nature, 2017-10-23)RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2
(ELSEVIER, 2015-10-22)The central role of translation in modulating gene activity has long been recognized, yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to a specific stimulus has only ... -
Generation and analysis of ESTs from strawberry (Fragaria xananassa) fruits and evaluation of their utility in genetic and molecular studies
(BMC, 2010-09-17)Cultivated strawberry is a octoploid species whose fruit is highly appreciated due to its organoleptic properties and health benefits. However, information about the role played by different hormones on these processes ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
(Frontiers, 2018-09-25)Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ... -
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
(Elsevier, 2017-04)The health benefits of olive oil are attributed to their bioactive compounds, such as hydroxytyrosol. Previously, we demonstrated that hydroxytyrosol inhibits angiogenesis in vitro. The present study aimed to: i) get further ... -
Insights into ROS‐dependent signalling underlying transcriptomic plant responses to the herbicide 2,4‐D
(Plant Cell & Environment, 2022)The synthetic auxin 2,4-dichlorophenoxyacetic acid (2,4-D) functions as an agronomic weed control herbicide. High concentrations of 2,4-D induce plant growth defects, particularly leaf epinasty and stem curvature. Although ... -
Integrating differential expression, co-expression and gene network analysis for the identification of common genes associated with tumor angiogenesis deregulation
(Elsevier, 2023)Angiogenesis is essential for tumor growth and cancer metastasis. Identifying the molecular pathways involved in this process is the first step in the rational design of new therapeutic strategies to improve cancer treatment. ... -
KinFams: De-Novo Classification of Protein Kinases Using CATH Functional Units
(IOAP-MDPI, 2023-02-02)Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary ... -
Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis.
(SpringerNature, 2022-05-19)Autophagy has vasculoprotective roles, but whether and how it regulates lymphatic endothelial cells (LEC) homeostasis and lymphangiogenesis is unknown. Here, we show that genetic deficiency of autophagy in LEC impairs ... -
MangoBase: a genomics portal and gene expression atlas for Mangifera indica
(MDPI, 2023-03-10)Mango (Mangifera indica L.) (2n = 40) is a member of the Anacardiaceae family, which was domesticated at least 4000 years ago in Asia. Mangoes are delicious fruits with great nutritional value. They are one of the major ... -
Mathematical modeling of cancer metabolism
(2018-10-19)Systemic approaches are needed and useful for the study of the very complex issue of cancer. Modeling has a central position in these systemic approaches. Metabolic reprogramming is nowadays acknowledged as an essential ... -
Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
(IOAP-MDPI, 2023-01-15)Glioblastoma multiforme is the most common primary brain tumor. Unfortunately, it is also one of the cancer types that has the worst morbidity and mortality ratios, so new targets and treatments need to be found. The ... -
Metabolic Reprogramming in Tumor Endothelial Cells.
(MDPI, 2022-09-21)The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical ...