Listar BMB - Artículos por título
Mostrando ítems 2-21 de 41
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A revised view on the evolution of glutamine synthetase isoenzymes in plants
Valderrama-Martín, José Miguel; Ortigosa, Francisco; Avila-Saez, Concepcion
; Canovas-Ramos, Francisco Miguel; Hirel, Bertrand; Cantón, Francisco R.; Cañas-Pendon, Rafael Antonio[et al.] (Wiley, 2022-02)
Glutamine synthetase (GS) is a key enzyme responsible for the incorporation of inorganic nitrogen in the form of ammonium into the amino acid glutamine. In plants, two groups of functional GS enzymes are found: eubacterial ... -
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
García-Vilas García, Javier Alejandro; Martinez-Poveda, Beatriz Amparo; Rodriguez-Quesada, Ana Maria; Medina Torres, Miguel Ángel (IOAP-MPDI, 2018-09-06)
The bioactive natural compound from marine origin, (+)-aeroplysinin-1, has been shown to exhibit potent anti-inflammatory and anti-angiogenic effects. The aim of the present study was to identify new targets for ... -
Allelic Variation of MYB10 is the Major Force Controlling Natural Variation of Skin and Flesh Color in Strawberry (Fragaria spp.) fruit
Castillejo, Cristina; Waurich, Veronika; Wagner, Henning; Ramos, Rubén; Oiza, Nicolás; Muñoz, Pilar; Triviño, Juan C; Caruana, Julie; Liu, Zhongchi; Cobo, Nicolás; Hardigan, Michael A; Knapp, Steven J; Vallarino, José G.; Osorio-Algar, Sonia; Martín-Pizarro, Carmen; Posé, David; Toivainen, Tuomas; Hytönen, Timo; Oh, Youngjae; Barbey, Christopher R; Whitaker, Vance M; Lee, Seonghee; Olbricht, Klaus; Sánchez-Sevilla, José F; Amaya, Iraida[et al.] (2020-06-13)
Anthocyanins are the principal color-producing compounds synthesized in developing fruits of strawberry (Fragaria spp.). Substantial natural variation in color have been observed in fruits of diploid and octoploid accessions, ... -
Ammonium regulates the development of pine roots through hormonal crosstalk and differential expression of transcription factors in the apex
Ortigosa, Francisco; Lobato-Fernández, César; Shikano, Hitomi; Avila-Saez, Concepcion; Taira, Shu; Canovas-Ramos, Francisco Miguel; Cañas-Pendon, Rafael Antonio[et al.] (Wiley, 2021-11-01)
Ammonium is a prominent source of inorganic nitrogen for plant nutrition, but excessive amounts can be toxic for many species. However, most conifers are tolerant to ammonium, a relevant physiological feature of this ancient ... -
Antioxidant responses related to temozolomide resistance in glioblastoma
Campos-Sandoval, Jose Angel; Gómez-García, María C.; Santos-Jiménez, Juan de los; Mates-Sanchez, Jose Manuel; Alonso, Francisco J.; Márquez-Gómez, Javier[et al.] (Elsevier, 2021)
Glioblastoma remains one of the most challenging and devastating cancers, with only a very small proportion of patients achieving 5-year survival. The current standard of care consists of surgery, followed by radiation ... -
Antioxidant, Immunomodulatory and Potential Anticancer Capacity of Polysaccharides (Glucans) from Euglena gracilis G.A. Klebs
Casas Arrojo, Virginia; Arrojo Agudo, María de los Ángeles; Cárdenas García, Casimiro; Carrillo, Paloma; Pérez Manríquez, Claudia; Martinez-Manzanares, Eduardo; Abdala-Diaz, Roberto Teofilo[et al.] (IOAP-MDPI, 2022-11-10)
The present study was carried out to determine the bioactivity of polysaccharides extracted from Euglena gracilis (EgPs). These were characterized by FT-IR and GC-MS. Cytotoxicity analyses (MTT) were performed on healthy ... -
Autophagy is required for strawberry fruit ripening
Sánchez-Sevilla, José F.; Botella-Mesa, Miguel Angel; Valpuesta-Fernandez, Victoriano; Sanchez-Vera, Victoria (Frontiers Media SA, 2021-08-27)
Autophagy is a catabolic and recycling pathway that maintains cellular homeostasis under normal growth and stress conditions. Two major types of autophagy, microautophagy and macroautophagy, have been described in plants. ... -
Bringing Light to Science Undergraduate Students: A Successful Laboratory Experiment Illustrating the Principles and Applications of Bioluminescence
García-Ponce, Ángel Luis; Torres-Vargas, José Antonio; García-Caballero, Melissa; Medina, Miguel ángel; Blanco-Lopez, Angel; Rodriguez-Quesada, Ana Maria[et al.] (ACS Publications, 2021)
Although many laboratory experiments are available to illustrate spectrophotometric or fluorometric methods, few of them introduce the use of luminometry to students. Bioluminescence, a subtype of chemiluminescence, ... -
Characterizing the involvement of FaMADS9 in the regulation of strawberry fruit receptacle development
Vallarino, José G.; Merchante, Catharina; Sánchez-Sevilla, José F; De Luis Balaguer, Maria Angels; Pott, Delphine; Ariza, María T; Casañal, Ana; Posé, David; Vioque, Amalia; Amaya, Iraida; Willmitzer, Lothar; Solano, Roberto; Sozzani, Rosangela; Fernie, Alisdair R; Botella-Mesa, Miguel Angel; Giovannoni, James J; Valpuesta-Fernandez, Victoriano; Osorio-Algar, Sonia[et al.] (Wiley Online Library, 2019-09-18)
FaMADS9 is the strawberry (Fragaria x ananassa) gene that exhibits the highest homology to the tomato (Solanum lycopersicum) RIN gene. Transgenic lines were obtained in which FaMADS9 was silenced. The fruits of these lines ... -
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Marrero, Ana Dácil; Castilla, Laura; Espartero, José L.; Madrona, Andrés; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Martinez-Poveda, Beatriz Amparo[et al.] (2020-09-22)
The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the ... -
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
López-Jiménez, Auxiliadora; Gallardo, Elena; Espartero, José L.; Madrona, Andrés; Medina, Miguel Ángel; Rodriguez-Quesada, Ana Maria[et al.] (Royal Society of Chemistry, 2018)
Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... -
Control of tumor angiogenesis and metastasis through modulation of cell redox state
Serrano, José J.; Delgado, Belén; Medina, Miguel Ángel (2020-09-22)
Redox reactions pervade all biology. The control of cellular redox state is essential for bioenergetics and for the proper functioning of many biological functions. This review traces a timeline of findings regarding the ... -
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sánchez, Lilian B.; Mari-Beffa, Manuel; Carrillo Fernández, Paloma; Medina, Miguel Ángel; Díaz-Cuenca, Aránzazu (2018-10-19)
The osteogenic and angiogenic responses of organisms to the ionic products of degradation of bioactive glasses (BGs) are being intensively investigated. The promotion of angiogenesis by copper (Cu) has been known for more ... -
Development and Validation of a Multilingual Lexicon as a Key Tool for the Sensory Analyses and Consumer Tests of Blueberry and Raspberry Fruit
Lippi, Nico; Senger, Elisa; Karhu, Saila; Mezzetti, Bruno; Cianciabella, Marta; Ayvaz Sönmez, Duygu; Fidelis, Marina; Gatti, Edoardo; Höfer, Monika; Ebru Kafkas, Nesibe; Mazzoni, Luca; McCallum, Susan; Olbricht, Klaus; Orsucci, Saverio; Osorio-Algar, Sonia; Pinczinger, Dora; Predieri, Stefano; Rokka, Susanna; Sánchez-Sevilla, José Federico; Savini, Gianluca; Soria, Carmen; Usadel, Björn; Zucchi, Paolo; Chiara, Medoro[et al.] (IOAP-MDPI, 2023-01-28)
A comprehensive lexicon is a necessary communication tool between the panel leader and panelists to describe each sensory stimulus potentially evoked by a product. In the current scientific breeding and trading scenario, ... -
Exploring the ring-closing metathesis for the construction of the solomonamide macrocyclic core: identification of bioactive precursors
Cheng-Sánchez, Iván; Sánchez-Ruiz, Antonio; Martinez-Poveda, Beatriz Amparo; Medina, Miguel Ángel; Carrillo Fernández, Paloma; Rodriguez-Quesada, Ana Maria; López-Romero, Juan Manuel; Sarabia-Garcia, Francisco Ramon[et al.] (2018-10-19)
New synthetic strategies directed toward the novel cyclopeptides solomonamides have been explored utilizing an olefin metathesis as the key reaction. In the various strategies investigated, we worked on minimally oxidized ... -
Fishing anti(lymph)angiogenic drugs with zebrafish
García-Caballero, Melissa; Rodriguez-Quesada, Ana Maria; Medina, Miguel Ángel; Mari-Beffa, Manuel (2018-10-19)
Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(Oxford University Press, 2019-01)The B-class of MADS-box transcription factors has been studied in many plant species, but remains functionally unchar- acterized in Rosaceae. APETALA3 (AP3), a member of this class, controls petal and stamen identities in ... -
Functional Analysis of TM6 MADS-box gene in the Octoploid Strawberry by CRISPR/Cas9 directed mutagenesis
(bioRxiv, 2018-06-20)The B-class of MADS-box transcription factors has been studied in many plant species, but remain functionally uncharacterized in the Rosaceae family. APETALA3 (AP3), a member of this class, controls the identity of petals ... -
Gene expression atlas of fruit ripening and transcriptome assembly from RNA-seq data in octoploid strawberry (Fragaria × ananassa)
Sánchez-Sevilla, José F; Vallarino, José G.; Osorio-Algar, Sonia; Bombarely, Aureliano; Posé, David; Merchante, Catharina; Botella-Mesa, Miguel Angel; Amaya, Iraida; Valpuesta-Fernandez, Victoriano[et al.] (Springer Nature, 2017-10-23)
RNA-seq has been used to perform global expression analysis of the achene and the receptacle at four stages of fruit ripening, and of the roots and leaves of strawberry (Fragaria × ananassa). About 967 million reads and ... -
Genome Editing as a Tool for Fruit Ripening Manipulation
(Frontiers, 2018-09-25)Over the last few years, a series of tools for genome editing have been developed, allowing the introduction of precise changes into plant genomes. These have included Zinc-finger nucleases (ZFNs), transcription activator-like ...